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Ulcerative Colitis – half have poor level of Vitamin D Receptor vs only one in ten normally – June 2017

Vitamin D Receptor Level in Biopsy Specimen of Patients with Ulcerative Colitis: Results from a Center in Western Anatolia

Journal of the National Medical Association, DOI: http://dx.doi.org/10.1016/j.jnma.2017.06.003

VitaminDWiki Summary

Patients with negative Vitamin D Receptor levels
UC 56%,   controls 10%

See also VitaminDWiki

Overview Gut and vitamin D contains the following summary

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 204 items

Gut category listing contains the following

204 items in GUT category - see also Overview Gut and vitamin D, See also Microbiome category listing has 37 items along with related searches.

23% of UC had poor VDR vs 7.7 % of controls - March 2019
Adv Clin Exp Med. 2019 Mar 28. doi: 10.17219/acem/97376
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Types of UC

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Adil Coskun, M.D. M.D. Adil Coskun, M.D. Adil Coskun, Irfan Yavasoglu, M.D., Ibrahim Meteoglu, M.D., Mustafa Unubol, M.D., Burak Yasar, M.D., Serkan Borazan, M.D., Imran Kurt Omurlu, M.D., Vahit Yukselen, M.D., M. Hadi Yasa, M.D.

Ulcerative colitis (UC) is a chronic, inflammatory bowel diseases characterized by uncontrolled inflammatory condition of the colon and rectal mucosa marked by recurrent periods of remission and exacerbation. Vitamin D receptor (VDR) is a member of the steroid receptor family that mediates the effects of vitamin D by regulating transcription of multiple cellular genes. We aimed to evaluate vitamin d receptor level in biopsy specimen of patients with UC in this study.

VDR levels were retrospectively studied in colon biopsy specimens of UC patients. The Spearman's rho correlation analysis, The Kolmogorov–Smirnov, Mann Whitney U, and chi-square tests were used for statistical analysis. The p values below 0.05 were considered statistically significant.

Study included 112 UC patients (65 male and 47 female) and 30 controls (19 female and 11 male) who had normal results in biopsy examinations carried out due to various reasons. VDR levels of UC patients were statistically lower than control subjects, and was not associated with duration of the disease and place of involvement.

VDR is an important receptor in the pathogenesis of UC, and optimizing vitamin D levels could have a therapeutic role in UC.

Created by admin. Last Modification: Thursday June 3, 2021 20:08:54 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
15704 UC types.jpg admin 03 Jun, 2021 48.16 Kb 722
11698 VDR UC 2019.pdf admin 01 Apr, 2019 182.27 Kb 769
8148 VDR UC.pdf admin 03 Jul, 2017 604.46 Kb 798