Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo: A meta-analysis.
Medicine (Baltimore). 2018 Jul;97(29):e11506. doi: 10.1097/MD.0000000000011506.
Zhang JZ1, Wang M2, Ding Y1, Gao F2, Feng YY1, Yakeya B1, Wang P1, Wu XJ1, Hu FX1, Xian J3, Kang XJ1.
1 Department of Dermatology.
2 Department of Gastroenterology.
3 Department of Gynecology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
- Vitiligo is associated with low vitamin D (nothing about treatment) – meta-analysis March 2016
- Vitamin D Receptor in vitiligo skin activated by UVB – May 2018
- Spotty skin coloring (vitiligo) treated by augmenting topical tacrolimus with oral Vitamin D – Oct 2016
- Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018 -Note: Vitiligo is an auto-immune disease
Subsequent Meta-analysis of Vitiligo and vitamin D in blood found a much smaller assocation
Decreased circulatory levels of Vitamin D in Vitiligo: a meta-analysis - 2021
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Increased risk of Vitiligo if:
Low Vitamin D in blood
Poor Vitamin D Receptor which restricts Vitamin D getting to skin cells
Increase intake of Vitamin D
Increase VDR activation (see below)
Autoimmune category starts with
187 items in Autoimmune category
- Vitamin D and MS Asthma RA Diabetes Gut Allergy Hay Fever Muscular Dystrophy Lupus Psoriasis
- Autoimmune disease clusters run in families having low D
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
- 120 doctors and 20,000 MS patients using high dose Vitamin D Dec 2018
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
- Vitamin D Receptor is associated in over 58 autoimmune studies
- Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019
Vitamin D Receptor category has the following
463 studies in Vitamin D Receptor category
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problemsSee also:
A poor VDR restricts Vitamin D from getting in the cells
44 studies in the Resveratrol category
It appears that 30% of the population have a poor VDR (40% of the Obese )Health problems include: Autoimmune (
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems
17 studies), Breast Cancer ( 20 studies), Colon Cancer ( 12 studies), Cardiovascular ( 22 studies), Cognition ( 16 studies), Diabetes ( 22 studies), Hypertension ( 6 studies), Infant ( 18 studies), Lupus ( 6 studies), Metabolic Syndrome ( 3 studies), Mortality ( 4 studies), Multiple Sclerosis ( 11 studies), Obesity ( 15 studies), Pregnancy ( 22 studies), Rheumatoid Arthritis ( 10 studies), TB ( 8 studies), VIRUS ( 30 studies), Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 45 diseases at least double with poor VDR as of Nov 2022 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
Compensate for poor VDR by increasing one or more:
Increasing Increases 1) Vitamin D supplement Sun
Vitamin D in the blood
and thus in the cells
2) Magnesium Vitamin D in the blood
AND in the cells
3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor 14)Butyrate especially gut Vitamin D Receptor
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
OBJECTIVES: To explore the relationship among the vitamin D receptor (VDR) gene polymorphisms, serum 25-hydroxyvitamin D levels, and vitiligo.
Databases including PubMed, Cochrane Library, Ovid, Web of Science, CNKI, SinoMed, and Wanfang Data were systematically searched. The association was assessed using odds ratios (ORs), standard mean difference (SMD), and 95% confidence intervals (CIs). The statistical tests were performed using Review Manager 5.3.3.
We identified a total of 17 studies. The relationship between VDR gene polymorphisms (BsmI, ApaI, TaqI, and FokI), serum 25 (OH)D levels, and incidence of vitiligo was investigated. The results of this meta-analysis showed that the
- dominant genetic model (CC+AC vs AA, P = .007, OR = 1.41, 95% CI = 1.10-1.80),
- recessive genetic model (CC vs AC+AA, P = .01, OR = 4.10, 95% CI = 1.36-12.35), and
- allelic contrast model (C vs A, P = .005, OR = 1.87, 95% CI = 1.21-2.90)
- of VDR Apal locus increased the risk of vitiligo, and BsmI, TaqI, and FokI loci and the risk of vitiligo have no obvious correlation.
Serum 25 (OH)D deficiency was positively associated with the incidence of vitiligo (P < .0001, SMD = -0.94, 95% CI = -1.39, -0.48).
This meta-analysis revealed that VDR Apal polymorphism increased the susceptibility risk of vitiligo, and there is a positive correlation between serum 25 (OH)D deficiency and the incidence of vitiligo.Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis July 2018
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