Table of contents
- Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors
- Sometimes A Disease ==> deactivates VDR, typically poor VDR ==> increased risk
- Suspect increased incidence of poor VDR in past 50 years
- VitaminDWiki - Vitamin D Receptor category contains
- 55 health problems associated with poor VDR
- How to increase VDR activation
- Increased risk of diseases if poor VDR
- Cancer is the most frequent health problem of VDR studies
- VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways
- 78 Cancer studies in VitaminDWiki were associated with poor VDR (as of July 2022)
Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors
Cancers (Basel). 2022 Jul 6;14(14):3295. doi: 10.3390/cancers14143295.
Orsolya Juhász 1, Noémi Jákob 2, Hajnalka Rajnai 2, Marcell Imrei 3 4, Miklós Garami 1
Background: Our previous work has shown a correlation between lower vitamin D levels in children with cancer and adverse prognosis. It suggests that supplying vitamin D is reasonable. VDR expression in childhood solid tumors has been linked to tumor characteristics and patient survival in only a few studies.
Methods: For this study, 177 children with solid tumors were selected whose biopsies and tumor tissue formalin-fixed, paraffin-embedded tissue blocks were available for immunohistochemical analysis at Semmelweis University, Budapest (Hungary).
Results: We found that non-significant VDR expression was associated with a significantly less favorable prognosis (p = 0.0061) in the examined childhood solid tumors. There was a clinically significant association; non-significant VDR expression had more than 14-fold odds of an unfavorable prognosis (OR = 14.74). The rate of VDR expression differed significantly between tumor types (p <0.0001).
Conclusion: In conclusion, VDR expression measured by IHC staining is inversely associated with aggressive characteristics in different childhood cancers. The downregulation of VDR expression in more aggressive childhood cancers suggests that functional vitamin D activity may slow or block cancer progression.
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Sometimes A Disease ==> deactivates VDR, typically poor VDR ==> increased risk
- Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies
- A virus that most adults have (Cytomegalovirus) decreases the amount of Vitamin D which gets to the cells – Jan 2017
- Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010
- COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021
Suspect increased incidence of poor VDR in past 50 years
Now a person can survive a poor VDR and pass a poor VDR gene onto their offspring
This lack of the survival of the fittest may be a major reason for the increase of health problems, such as childhood cancers
Have been unable to find studies of trends of VDR incidence
VitaminDWiki - Vitamin D Receptor category contains
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
| Increasing | Increases |
| 1) Vitamin D supplement Sun Ultraviolet -B | Vitamin D in the blood and thus in the cells |
| 2) Magnesium | Vitamin D in the blood AND in the cells |
| 3) Omega-3 | Vitamin D in the cells |
| 4) Resveratrol | Vitamin D Receptor |
| 5) Intense exercise | Vitamin D Receptor |
| 6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
| 7) Quercetin (flavonoid) | Vitamin D Receptor |
| 8) Zinc is in the VDR | Vitamin D Receptor |
| 9) Boron | Vitamin D Receptor ?, etc |
| 10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
| 11) Progesterone | Vitamin D Receptor |
| 12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D Receptor |
| 13) Sulfroaphane and perhaps sulfur | Vitamin D Receptor |
| 14) Butyrate especially gut | Vitamin D Receptor |
| 15) Berberine | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Increased risk of diseases if poor VDR
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
Cancer is the most frequent health problem of VDR studies
Trend research of vitamin D receptor: Bibliometric analysis: 2021 PDF
VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Butyrate Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators
78 Cancer studies in VitaminDWiki were associated with poor VDR (as of July 2022)
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| 18191 | VDR child cancers_CompressPdf.pdf | admin 27 Jul, 2022 | 442.12 Kb | 280 |