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Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020

The roles of vitamin D and cathelicidin on type 1 diabetes susceptibility

Review Endocr Connect, 2020 Dec 1;EC-20-0484.R1. doi: 10.1530/EC-20-0484
Cecília Cristelo 1, Alexandra Machado 2, Bruno Sarmento 3, Francisco Miguel Gama 4

VitaminDWiki
37 articles are in both Diabetes and infant-Child categories (proxie for T1 Diabetes)


Items in categories Infant-Child & Diabetes & Meta-analysis:


Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 479 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
    • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

  • Dark Skin 23;   Intervention 52;   Meta-analysis 34;   Obesity 28;  Pregnancy 40;   T1 (child) 37;  Omega-3 11;  Vitamin D Receptor 21;  Genetics 11;  Magnesium 19    Click here to see details

Diabetic Epidemic

  • Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
    Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
    That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
    Chart from the web (2018?)
    Image


162 pages in VitaminDWiki have cathelicidin as of Dec 2020

Autoimmune category starts with


Items in both categories Autoimmune and Diabetes are listed here:


See also web

  • Chapter thirteen - Vitamin D, Vitamin D Receptor, and Cathelicidin in the Treatment of Tuberculosis - 2011 https://doi.org/10.1016/B978-0-12-386960-9.00013-7
  • Effect of cholecalciferol supplementation on vitamin D status and cathelicidin levels in sepsis: A randomized, placebo-controlled trial - Sept 2015 FREE PDF
  • Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective? - Sept 2020 FREE PDF

 Download the PDF from VitaminDWiki

Type 1 diabetes has increasingly greater incidence and prevalence with no cure available. Vitamin D supplementation is well documented to reduce the risk of developing type 1 diabetes. Being involved in the modulation of cathelicidin expression, the question whether cathelicidin may be one of the underlying cause arises. Cathelicidin has been implicated in both the development and the protection against type 1 diabetes by mediating the interplay between the gut microbiome, the immune system and β cell function. While its potential on type 1 diabetes treatment seems high, the understanding of its effects is still limited. This review aims to contribute to a more comprehensive understanding of the potential of vitamin D and cathelicidin as adjuvants in type 1 diabetes therapy.


Created by admin. Last Modification: Thursday December 3, 2020 15:07:55 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
14659 vitamin D and cathelicidin on type 1 diabetes.pdf admin 03 Dec, 2020 14:04 1.17 Mb 88
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