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Low Vitamin D is a causal factor for Multiple Sclerosis (Mendelian analysis) – Jan 2020

BMI and Low Vitamin D Are Causal Factors for Multiple Sclerosis: A Mendelian Randomization Study

Neurol Neuroimmunol Neuroinflamm, 7 (2) 2020 Jan 14, DOI: 10.1212/NXI.0000000000000662
Benjamin M Jacobs 1, Alastair J Noyce 1, Gavin Giovannoni 1, Ruth Dobson 2


This appears to examine only those genes which restrict Vitamin Dblood levels
And not those genes which restrict D in the blood getting to the tissues
   Example gene: Vitamin D Receptor
Items in both categories Multiple Sclerosis and Vitamin D Receptor are listed here:

There would have been an even stronger causation factor for Vitamin D if the other genes has also been considered

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

 Download the PDF from VitaminDWiki

Objective: To update the causal estimates for the effects of adult body mass index (BMI), childhood BMI, and vitamin D status on multiple sclerosis (MS) risk.

Methods: We used 2-sample Mendelian randomization to determine causal estimates. Summary statistics for SNP associations with traits of interest were obtained from the relevant consortia. Primary analyses consisted of random-effects inverse-variance-weighted meta-analysis, followed by secondary sensitivity analyses.

Results: Genetically determined increased childhood BMI (ORMS 1.24, 95% CI 1.05-1.45, p = 0.011) and adult BMI (ORMS 1.14, 95% CI 1.01-1.30, p = 0.042) were associated with increased MS risk. The effect of genetically determined adult BMI on MS risk lessened after exclusion of 16 variants associated with childhood BMI (ORMS 1.11, 95% CI 0.97-1.28, p = 0.121). Correcting for effects of serum vitamin D in a multivariate analysis did not alter the direction or significance of these estimates. Each genetically determined unit increase in the natural-log-transformed vitamin D level was associated with a 43% decrease in the odds of MS (OR 0.57, 95% CI 0.41-0.81, p = 0.001).

Conclusions: We provide novel evidence that BMI before the age of 10 is an independent causal risk factor for MS and strengthen evidence for the causal role of vitamin D in the pathogenesis of MS.

Created by admin. Last Modification: Thursday January 16, 2020 14:00:46 GMT-0000 by admin. (Version 8)

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13350 Low D causes MS.pdf PDF 2020 admin 16 Jan, 2020 13:36 474.29 Kb 403