Vitamin D receptor gene polymorphisms in atopy
Immun Inflamm Dis. 2021 Aug 3. doi: 10.1002/iid3.487
Laura Tamasauskiene 1, Ieva Golubickaite 2, Rasa Ugenskiene 2, Nikolajs Sjakste 3, Natalia Paramonova 3, Lawrence Shih-Hsin Wu 4, Lawrence Shih-Jiu-Yao Wang 5 6, Brigita Sitkauskiene 1
Background: The occurrence of allergic conditions, for example allergic asthma, rhinitis, and atopic dermatitis, is rising worldwide. These allergic conditions are associated with poor life quality. Vitamin D is proposed to be linked with increased risk and severe forms of allergic diseases.
Aims: This review article aimed to evaluate the vitamin D level role and polymorphisms of vitamin D receptor gene (VDR) in atopy.
Methods & materials: We analyzed publications that were focusing on levels of vitamin D and/or polymorphism analysis of vitamin D receptor gene in allergic asthma, rhinitis, and atopic dermatitis patients.
Results: We noticed that levels of vitamin D are extensively studied in atopy by many research groups, however, polymorphisms of vitamin D receptor gene and their link with levels of vitamin D lack comprehensive data. There is evidence that vitamin D may be associated with anti-inflammatory effects in allergic diseases. Some of VDR polymorphisms also may play a role in pathogenesis of these diseases. However, the data from different studies are controversial.
Discussion: The results of different studies are usually inconsistent, most probably due to populational bias or differences in methodology. Even though, more evidence shows a positive impact of vitamin D on the risk and outcomes of allergic diseases, especially atopic dermatitis, and asthma.
Conclusions: There is controversial data about the level of vitamin D and its role in atopy; however, more evidence shows a positive impact on the risk and outcomes of allergic diseases.
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VitaminDWiki: Asthma, VDR
Overview Asthma and Vitamin D
This list is automatically updated
Items found: 9
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Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023 |
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21 Dec, 2023 |
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2X increase risk of Asthma if a particular Vitamin D Receptor mutation – meta-analysis Feb 2022 |
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04 Jul, 2022 |
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Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021 |
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04 Aug, 2021 |
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Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019 |
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01 Jul, 2021 |
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Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019 |
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07 Nov, 2019 |
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Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019 |
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23 Oct, 2019 |
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Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016 |
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12 Nov, 2016 |
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2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015 |
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09 Sep, 2015 |
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Strong Vitamin D deficiency associations in Asthma patients – Nov 2014 |
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18 Nov, 2014 |
Vitamin D Receptor is associated in over 40 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators
Asthma and low vitamin D
VitaminDWiki pages with ALLERG in the title
Items found: 27
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Overview Rare Allergic reaction to vitamin D |
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15 Jul, 2023 |
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People allergic to Lanolin should not be allergic to vegan Vitamin D |
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20 Mar, 2023 |
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Allergic rhinitis sublingual therapy was 22X more successful if good level of Vitamin D – Feb 2023 |
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15 Mar, 2023 |
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Allergic to multiple foods: 4 in 10 kids, 5 in 10 adults (note: Vitamin D helps) - Dec 2022 |
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06 Jan, 2023 |
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Vitamin D reduces childhood allergic airway diseases (confirmed by metabolomics this time) – May 2022 |
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26 May, 2022 |
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Allergic reactions to Insect sting decreased by topical Vitamin D (frequent) |
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09 Aug, 2019 |
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Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019 |
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23 Jul, 2019 |
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Pink eye (seasonal allergic conjunctivitis) associated with low vitamin D and high vitamin E – March 2014 |
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14 Jul, 2019 |
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6X as many people with allergic rhinitis were severely vitamin D deficient – Jan 2012 |
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30 Jun, 2019 |
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Hypothesis: Allergic diseases have increased because of decreased vitamin D – Oct 2014 |
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01 Jul, 2018 |
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Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018 |
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31 Jan, 2018 |
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Hay fever (allergic rhinitis) risk reduced 20 percent for each 100 IU of vitamin D during early pregnancy – Feb 2016 |
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23 Aug, 2016 |
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Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel – Dec 2011 |
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17 Jun, 2016 |
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Less sun (less vitamin D) more anaphylaxis (severe allergic reaction) – June 2014 |
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17 Jun, 2016 |
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11X more non-immigrant children allergic to peanuts if vitamin D less than 20 ng – Feb 2013 |
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17 Apr, 2016 |
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New Zealand – new 50,000 IU vitamin D capsule has soy which can cause allergic reactions – March 2016 |
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09 Mar, 2016 |
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Allergic to the sun (Polymorphic light eruption) – you may need UVB or vitamin D |
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26 Jan, 2016 |
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Asthma associated with low vitamin D, independent of allergic status – Nov 2015 |
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25 Nov, 2015 |
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Allergic Rhinitis (hay fever) reduced by just 1,000 IU of vitamin D for 30 days – RCT Sept 2015 |
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02 Nov, 2015 |
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Low vitamin D at birth associated with later milk sensitization, allergic rhinitis and asthma – Nov 2014 |
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22 Oct, 2015 |
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Allergic rhinitis associated with less vitamin D in men yet more in women – Jan 2014 |
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05 Jul, 2015 |
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Off topic: Large dose of Vitamin A increased allergic reaction in girls by 1.8X – RCT May 2015 |
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02 May, 2015 |
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Vitamin D in Allergic and Immune Disorders - Nov 2013 |
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18 Nov, 2013 |
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Allergic rhinitis 56 percent more likely if low vitamin D – Nov 2013 |
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23 Oct, 2013 |
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Vitamin D supplements increased probability of allergic rhinitis by 66 percent - 2004 |
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23 Oct, 2013 |
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Allergic diseases in the elderly – Oct 2011 |
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10 Jan, 2012 |
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Review of vitamin D asthma and allergic diseases – abstract lacks details July 2010 |
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20 Aug, 2010 |
VitaminDWiki - Vitamin D Receptor pages with "ASTHMA" in title
This list is automatically updated
Items found: 9
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Modified |
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Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023 |
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21 Dec, 2023 |
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2X increase risk of Asthma if a particular Vitamin D Receptor mutation – meta-analysis Feb 2022 |
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04 Jul, 2022 |
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Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021 |
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04 Aug, 2021 |
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Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019 |
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01 Jul, 2021 |
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Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019 |
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07 Nov, 2019 |
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Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019 |
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23 Oct, 2019 |
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Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016 |
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12 Nov, 2016 |
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2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015 |
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09 Sep, 2015 |
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Strong Vitamin D deficiency associations in Asthma patients – Nov 2014 |
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18 Nov, 2014 |