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Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021

Vitamin D receptor gene polymorphisms in atopy

Immun Inflamm Dis. 2021 Aug 3. doi: 10.1002/iid3.487
Laura Tamasauskiene 1, Ieva Golubickaite 2, Rasa Ugenskiene 2, Nikolajs Sjakste 3, Natalia Paramonova 3, Lawrence Shih-Hsin Wu 4, Lawrence Shih-Jiu-Yao Wang 5 6, Brigita Sitkauskiene 1

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Overview Asthma and Vitamin D contains


Vitamin D Receptor is associated in over 40 autoimmune studies

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators

Asthma and low vitamin D

VitaminDWiki pages with ALLERG in the title

Items found: 23
Title Modified
Allergic reactions to Insect sting decreased by topical Vitamin D (frequent) 09 Aug, 2019
Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019 23 Jul, 2019
Pink eye (seasonal allergic conjunctivitis) associated with low vitamin D and high vitamin E – March 2014 14 Jul, 2019
6X as many people with allergic rhinitis were severely vitamin D deficient – Jan 2012 30 Jun, 2019
Hypothesis: Allergic diseases have increased because of decreased vitamin D – Oct 2014 01 Jul, 2018
Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018 31 Jan, 2018
Overview Rare Allergic reaction to vitamin D 23 Jan, 2017
Hay fever (allergic rhinitis) risk reduced 20 percent for each 100 IU of vitamin D during early pregnancy – Feb 2016 23 Aug, 2016
Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel – Dec 2011 17 Jun, 2016
Less sun (less vitamin D) more anaphylaxis (severe allergic reaction) – June 2014 17 Jun, 2016
11X more non-immigrant children allergic to peanuts if vitamin D less than 20 ng – Feb 2013 17 Apr, 2016
New Zealand – new 50,000 IU vitamin D capsule has soy which can cause allergic reactions – March 2016 09 Mar, 2016
Allergic to the sun (Polymorphic light eruption) – you may need UVB or vitamin D 26 Jan, 2016
Asthma associated with low vitamin D, independent of allergic status – Nov 2015 25 Nov, 2015
Allergic Rhinitis (hay fever) reduced by just 1,000 IU of vitamin D for 30 days – RCT Sept 2015 02 Nov, 2015
Low vitamin D at birth associated with later milk sensitization, allergic rhinitis and asthma – Nov 2014 22 Oct, 2015
Allergic rhinitis associated with less vitamin D in men yet more in women – Jan 2014 05 Jul, 2015
Off topic: Large dose of Vitamin A increased allergic reaction in girls by 1.8X – RCT May 2015 02 May, 2015
Vitamin D in Allergic and Immune Disorders - Nov 2013 18 Nov, 2013
Allergic rhinitis 56 percent more likely if low vitamin D – Nov 2013 23 Oct, 2013
Vitamin D supplements increased probability of allergic rhinitis by 66 percent - 2004 23 Oct, 2013
Allergic diseases in the elderly – Oct 2011 10 Jan, 2012
Review of vitamin D asthma and allergic diseases – abstract lacks details July 2010 20 Aug, 2010

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Background: The occurrence of allergic conditions, for example allergic asthma, rhinitis, and atopic dermatitis, is rising worldwide. These allergic conditions are associated with poor life quality. Vitamin D is proposed to be linked with increased risk and severe forms of allergic diseases.

Aims: This review article aimed to evaluate the vitamin D level role and polymorphisms of vitamin D receptor gene (VDR) in atopy.

Methods & materials: We analyzed publications that were focusing on levels of vitamin D and/or polymorphism analysis of vitamin D receptor gene in allergic asthma, rhinitis, and atopic dermatitis patients.

Results: We noticed that levels of vitamin D are extensively studied in atopy by many research groups, however, polymorphisms of vitamin D receptor gene and their link with levels of vitamin D lack comprehensive data. There is evidence that vitamin D may be associated with anti-inflammatory effects in allergic diseases. Some of VDR polymorphisms also may play a role in pathogenesis of these diseases. However, the data from different studies are controversial.

Discussion: The results of different studies are usually inconsistent, most probably due to populational bias or differences in methodology. Even though, more evidence shows a positive impact of vitamin D on the risk and outcomes of allergic diseases, especially atopic dermatitis, and asthma.

Conclusions: There is controversial data about the level of vitamin D and its role in atopy; however, more evidence shows a positive impact on the risk and outcomes of allergic diseases.


Created by admin. Last Modification: Wednesday August 4, 2021 01:30:29 GMT-0000 by admin. (Version 8)

Attached files

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16027 VDR low D Atopy.jpg admin 04 Aug, 2021 00:57 47.33 Kb 168
16026 Atopy VDR.pdf PDF 2021 admin 04 Aug, 2021 00:57 722.97 Kb 42
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