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Calcidiol

19 items in Calcidiol category

See also categories

Tests for Vitamin D 122 items

Calcitriol 42 items

Injection 42 items

Forms of Vitamin D 70 items

Did you know?
  • Calcidiol = 25-hydroxyvitamin D3 = 25(OH)D = 25-hydroxycholecalciferol
    = results of a Vitamin D blood = C27H44O2 = Calcifediol (Wikipedia)
  • Calcidiol is semi-activated Vitamin D
  • Semi-activation is accomplished by enzymes: CYP2A1 in liver and/or CYP2R1 in cells
  • Calcidiol is also available as a drug, an herb, and from eggs and meat
  • Calcitiol is fully activated into Calcitiol by CYP27B1 enzymes in Kidney and/or cells
          (More Calcidiol info below this box)

Learn how Vitamin D is essential for good health
  Watch a 5 minute video "Does Less Sun Mean more Disease?"
  Browse for other Health Problems and D in left column or here
  see also Supplementing and More in the menu at the top of very page
If you have a disease associated with low Vit D take Vit D
Raising your Vit D levels will substantially prevent other low-Vit D health problems
Often your specific health problem will also be treated

Blood Test Misses a lot (VDW 3439)
click on image for details


Getting Vitamin D into your body has the following chart

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Here are the main Calcidiol articles


Calcidiol - daily dose has fast response, but weekly might be better - March 2018

Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens.
Osteoporos Int. 2017 Nov;28(11):3239-3249. doi: 10.1007/s00198-017-4180-3. Epub 2017 Aug 16.
Minisola S1, Cianferotti L2, Biondi P1, Cipriani C1, Fossi C2, Franceschelli F2, Giusti F2, Leoncini G2, Pepe J1, Bischoff-Ferrari HA3, Brandi ML4.

 Download the PDF from VitaminDWiki
Daily high dose raised blood levels quickly
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FGF23 - similar large daily dose and weekly dose
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1,25 similar response to all tratments
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Least Calcium lost in Urine = weekly
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RATIONALE: Calcidiol can be employed to correct vitamin D deficiency.

MAIN RESULTS: Calcidiol administered at daily and weekly regimens over a period of 3 months was able to successfully raise 25-hydroxyvitamin D levels without altering other markers related to bone and mineral metabolism.

SIGNIFICANCE: Calcidiol supplementation is effective and safe.

INTRODUCTION:
The correction of vitamin D status is necessary to maintain an optimal mineral and skeletal homeostasis. Despite cholecalciferol (vitamin D3) is the most commonly used drug for vitamin D supplementation, the more hydrophilic compound calcidiol (25-hydroxyvitamin D3) can be employed at daily, weekly, and monthly regimens to reach in the short term the target levels of serum 25-hydroxyvitamin D [25(OH)D]. In the administration of different doses of calcidiol pharmacokinetic study (ADDI-D study), the efficacy and safety of daily and weekly dosages of calcidiol were tested.

METHODS:
A total of 87 Caucasian, community-dwelling, postmenopausal women, aged 55 years or older, with vitamin D inadequacy (serum 25(OH)D levels <30 ng/ml, with mean 25(OH)D below 20 ng/ml, namely 16.5 ± 7.5 ng/ml) were randomized to receive three different dosages of calcidiol: 20 μg/day, 40 μg/day, and 125 μg/week for 3 months. The attained level of serum 25(OH)D was selected as primary endpoint to assess efficacy, while other parameters of mineral metabolism, (serum calcium, parathyroid hormone, phosphate, FGF23, urinary calcium, and markers of bone turnover) were assessed as secondary endpoints to establish safety.

RESULTS:
In all the three groups, serum 25(OH)D values significantly and promptly rose and plateaued above the 30 ng/ml threshold remaining within safety interval after 14 days of treatment, with similar efficacy for the similar daily and weekly dose regimens. The different dosages were also equally effective in controlling secondary hyperparathyroidism. No significant changes in calcium and phosphate metabolism and in bone turnover markers were observed for any of the treatments, confirming the safety of this compound.

CONCLUSIONS:
The results of this study demonstrate the short- and mid-term efficacy and safety on core parameters of mineral metabolism of different daily or weekly dosages of calcidiol when used to treat vitamin D inadequacy or deficiency in postmenopausal women. Further studies are needed to assess falls as primary outcome of calcidiol supplementation.

PMID: 28815282 DOI: 10.1007/s00198-017-4180-3

Created by admin. Last Modification: Sunday March 11, 2018 01:00:26 UTC by admin. (Version 29)

Attached files

ID Name Comment Uploaded Size Downloads
9487 Caclium in urine.jpg admin 10 Mar, 2018 16:32 19.71 Kb 183
9485 calcidiol 1,25 daily weekl.jpg admin 10 Mar, 2018 16:19 14.36 Kb 183
9483 calcidiol daily weekl.jpg admin 10 Mar, 2018 16:17 32.22 Kb 183
9482 Calcidiol FGF23.jpg admin 10 Mar, 2018 16:17 14.29 Kb 189
9481 calcidiol daily weekly.pdf PDF 2018 admin 10 Mar, 2018 16:16 921.11 Kb 124
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