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Diabetes decreased by activating Vitamin D Receptor (transgenic mice) – Feb 2020

Vitamin D Receptor overexpression in β-cells ameliorates diabetes in mice

Diabetes 2020 Feb; https://doi.org/10.2337/db19-0757
Meritxell Morró, Laia Vilà, Sylvie Franckhauser, Cristina Mallol, Gemma Elias, Tura Ferré, Maria Molas, Estefanía Casana, Jordi Rodó, Anna Pujol, Noèlia Téllez, Fàtima Bosch, Alba Casellas

VitaminDWiki

Little benefit from vitamin D until it gets to the cells.
Vitamin D Receptor activation increases the amount of Vitamin D in the blood which actually gets to the cells
Vitamin D Receptor is associated in over 58 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
It appears that 30% of the unhealthy population has poor vitamin D receptor activation (40% of obese)

You do not have to become a transgenic mouse to increase vitamin D getting to your cells
 
Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc
  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators


Items in both categories Diabetes and Vitamin D Receptor are listed here:


Vitamin D deficiency has been associated with increased incidence of diabetes, both in humans and animal models. In addition, association between vitamin D receptor (VDR) gene polymorphisms and diabetes has also been described. However, the involvement of VDR in the development of diabetes, specifically in pancreatic β-cell, has not been elucidated yet. Here we aimed to study the role of VDR in β-cell in the pathophysiology of diabetes. Our results indicate that Vdr expression was modulated by glucose in healthy islets and decreased in islets from both T1D and T2D mouse models. In addition, transgenic mice overexpressing VDR in β-cell were protected against STZ-induced diabetes, and presented a preserved β-cell mass and a reduction in islet inflammation. Altogether, these results suggest that sustained VDR levels in β-cells may preserve β-cell mass and β-cell function and protect against diabetes.


Created by admin. Last Modification: Saturday February 22, 2020 14:33:44 GMT-0000 by admin. (Version 4)
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