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Epigenetics and Vitamin D – many studies

18+ VitaminDWiki pages with EPIGENETICS in the title

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Items found: 19
Title Modified
Vitamins etc, appear to slow down epigenetic aging and reduce inflammation – March 2024 26 Mar, 2024
Epigenetics and Vitamin D – many studies 23 Oct, 2023
Vitamin D Health problems can run in families (epigenetics, they miss other reasons) – June 2023) 16 Jun, 2023
Vitamin D supplementation is associated with slower epigenetic aging - May 2022 21 Jun, 2022
Epigenetics, vitamin D, and Multiple Sclerosis 15 Jun, 2022
Epigenetics - PDFs and links, with and without Vitamin D 25 Feb, 2021
Epigenetics identified Cervical Cancer 100 percent of time – 2019 23 Dec, 2019
Stressors as a fetus or child can cause health problems in adult (perhaps via epigenetics) – Dec 2017 14 Oct, 2018
Health problems can persist through many generations – Epigenetics and Vitamin D 13 Oct, 2018
Epigenetics meets endocrinology – 2011 13 Oct, 2018
Vitamin D Receptor – environment, genetics and epigenetics – May 2015 13 Oct, 2018
Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016 05 May, 2016
Epigenetics of Multiple Sclerosis – March 2014 06 Sep, 2015
Micronutrients, methylation, epigenetics, longevity podcast by Rhonda Patrick and Tim Ferriss - June 2015 22 Jun, 2015
Epigenetics meets endocrinology - 2011 21 Jan, 2015
Hypothesis: Epigenetics, vitamin D, and Multiple Sclerosis – Nov 2012 29 Aug, 2014
Epigenetics of prostate cancer and vitamin D – June 2010 09 Jul, 2013
Lung disease, vitamin D, and epigenetics – Aug 2011 13 Feb, 2012
Epigenetics and vitamin D – June 2010 clips from the web 05 Jun, 2010

Evidence in support of the Strong Epigenetic Theory of Aging - Oct 2020

Mice have 800,000 sites, of which just over 20% change significantly with age.

  • "...there are 10x (!) more gene pathways where methylation increases with age, which usually correlates with a decrease in gene expression, than pathways where the opposite happens"

Vitamin D, COPD, and Epigenetics – Aug 2011

Vitamin D and Susceptibility of Chronic Lung Diseases: Role of Epigenetics.
Front Pharmacol. 2011;2:50
Sundar IK, Rahman I.
Lung Biology and Disease Program, Department of Environmental Medicine, University of Rochester Medical Center Rochester, NY, USA.

Vitamin D deficiency is linked to accelerated decline in lung function, increased inflammation, and reduced immunity in chronic lung diseases. Epidemiological studies have suggested that vitamin D insufficiency is associated with low lung function in susceptible subjects who are exposed to higher levels of environmental agents (airborne particulates). Recent studies have highlighted the role of vitamin D and vitamin D receptor (VDR) in regulation of several genes that are involved in inflammation, immunity, cellular proliferation, differentiation, and apoptosis.

Vitamin D has also been implicated in reversal of steroid resistance and airway remodeling, which are the hallmarks of chronic obstructive pulmonary disease (COPD) and severe asthma. VDR protein level is decreased in lungs of patients with COPD. VDR deficient mice develop an abnormal lung phenotype with characteristics of COPD, such as airspace enlargement and decline in lung function associated with increased lung inflammatory cellular influx, and immune-lymphoid aggregates formation.

Dietary vitamin D may regulate epigenetic events, in particular on genes which are responsible for COPD susceptibility. Active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) plays an essential role in cellular metabolism and differentiation via its nuclear receptor (VDR) that cooperates with several other chromatin modification enzymes (histone acetyltransferases and histone deacetylases), thereby mediating complex epigenetic events in vitamin D signaling and metabolism.

This review provides an update on the current knowledge and understanding on vitamin D, and susceptibility of chronic lung diseases in relation to the possible role of epigenetics in its molecular action. Understanding the molecular epigenetic mechanism of vitamin D/VDR would provide rationale for dietary vitamin D-mediated intervention in prevention and management of chronic lung diseases linked with vitamin D deficiency.
see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=2047
 Download the PDF from VitaminDWiki.

Noteable Epigenetics and Vitamin D studies by Perplexity AI April 2024

  1. Maternal Vitamin D Depletion and DNA Methylation
    A study published in Clinical Epigenetics in 2016 found that maternal vitamin D status plays a crucial role in determining DNA methylation states in both the germline and soma across multiple generations. This study demonstrated that maternal vitamin D depletion can lead to long-term effects on the epigenome of subsequent generations, suggesting that vitamin D-induced changes in methylation are likely the result of sporadic epimutations due to global dysregulation 1.
  2. Vitamin D, DNA Methylation, and Breast Cancer
    Research from the National Institute of Environmental Health Sciences explored the relationships between serum vitamin D levels, DNA methylation, and breast cancer risk. This study utilized a case-cohort sample to examine the association between serum 25-hydroxyvitamin D 3].
  3. Vitamin D and Epigenetic Aging
    A study published in GeroScience in 2022 analyzed the relationship between vitamin D supplementation and epigenetic aging. The findings suggested that vitamin D supplementation is associated with slower epigenetic aging, highlighting the potential of vitamin D in influencing biological age through epigenetic mechanisms
  4. Vitamin D and Autoimmunity
    A review in NCBI discussed the role of vitamin D as a nutri-epigenetic factor in autoimmunity. The review highlighted how vitamin D might alter the risk of diseases like colorectal cancer by mediating the methylation of Wnt regulatory genes, demonstrating the epigenetic influence of vitamin D in disease modulation 11.
  5. Systematic Review on Vitamin D and Epigenetics
    A systematic review until 2023 examined the epigenetic modulation of vitamin D-related genes and its impact on vitamin D levels. The review summarized literature assessing the association between epigenetic modification of genes involved in the vitamin D metabolic pathway and the status of vitamin D metabolites, indicating significant variance in vitamin D levels due to epigenetic modifications 2.

See also VitaminDWiki

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Attached files

ID Name Comment Uploaded Size Downloads
21138 Epigenetics Vitamin D_CompressPdf.pdf admin 29 Apr, 2024 259.84 Kb 4
781 Vitamin D, COPD, and Epigenetics - Aug 2011.pdf admin 28 Sep, 2011 1.51 Mb 1510