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Pneumonia and low vitamin D - many studies

Pneumonia Risk, intensity, and mortality are all associated with low vitamin D

Pneumonia in VitaminDWiki

Risk Factor estimates for Pneumonia


Children and Pneumonia

79+ Pneumonia and Vitamin D publications (PubMed)

  • Effect of Adjunctive Single High-Dose Vitamin D 3 on Outcome of Community-Acquired Pneumonia in Hospitalised Adults: The VIDCAPS Randomised Controlled Trial - Sept 2018  Download the RCT PDF from VitaminDWiki
    • 17X more likely for Pneumonia to go away in those starting with <10 ng and getting a single dose of 200,000 IU of Vitamin D
    • Note: Not statistically significant
  • The Association Between Vitamin D Deficiency and Community-Acquired Pneumonia: A Meta-Analysis of Observational Studies - Sept 2019
  • Effect of Vitamin D Supplementation in the Prevention of Recurrent Pneumonia in Under-Five Children - Dec 2019,DOI: 10.1007/s12098-019-03025-z
  • Vitamin D Supplementation for Treatment and Prevention of Pneumonia in Under-five Children: A Randomized Double-blind Placebo Controlled Trial - Aug 2016  Download the RCT PDF from VitaminDWiki
    • 100,000 IU temporaily raised vitamin D levels by an average of 30 ng, not much benefit (needed much larger dose)

Pneumonia in the web

  • https://en.wikipedia.org/wiki/Pneumonia
    "Pneumonia affects approximately 450 million people globally (7% of the population) and results in about 4 million deaths per year"
    "Pneumonia often shortens suffering among those already close to death and has thus been called "the old man's friend"."
    "Pneumonia is due to infections caused primarily by bacteria or viruses and less commonly by fungi and parasites."
    "Conditions and risk factors that predispose to pneumonia include
    • smoking, immunodeficiency, alcoholism, chronic obstructive pulmonary disease, asthma, chronic kidney disease, and liver disease."
    • Note by VitaminDWiki - every one of those risk factors is also associated with low vitamin D levels
  • https://en.wikipedia.org/wiki/Community-acquired_pneumonia much less likely to be due to a superbug
  • Sunshine, rainfall, humidity and child pneumonia in the tropics: time-series analyses June 2013
    "Lack of sunshine was most strongly associated with pneumonia in both lagged regression. . . and case-crossover analysis"
    "This association is well known in temperate settings but has not been noted previously in the tropics"
  • Search Google for heliotherapy pneumonia 31,000 items
    sun therapy for pneumonia, TB, etc. was common before the invention of antibiotics
  • Be in the Know About Pneumonia Mercola June 2016?
    "These rates resulted in pneumonia being addressed as the eighth leading cause of death in the U.S., tied with influenza."
    ". . .it’s one of the two main causes of hospitalization, apart from childbirth."

Pneumonia elderly death 12X more likely when vitamin D less than 12 ng – 2011

Vitamin D, Innate Immunity and Outcomes in Community Acquired Pneumonia
1. Leong Leow1, 2. Talia Simpson3, 3. Ray Cursons3, 4. Noel Karalus1, 5. Robert J Hancox1,2,*
DOI: 10.1111/j.1440-1843.2011.01924.x

Background and objective Vitamin D regulates the production of the antimicrobial peptides cathelicidin and beta defensin-2, which play an important role in the innate immune response to infection. We hypothesised that vitamin D deficiency would be associated with lower levels of these peptides and worse outcomes in patients admitted to hospital with community-acquired pneumonia.

Methods Associations between mortality and serum levels of 25-hydroxyvitamin D, cathelicidin, and beta defensin-2 were investigated in a prospective cohort of 112 patients admitted with community-acquired pneumonia during winter.

Results Severe 25-hydroxyvitamin D deficiency (<30nmol/L) was common in this population (15%) and was associated with a higher 30-day mortality compared to patients with sufficient 25-hydroxyvitamin D(>50nmol/L) (OR 12.7, 95%CI 2.2-73.3, p = 0.004).

These associations were not explained by differences in age, co-morbidities, or the severity of the acute illness.
Neither cathelicidin nor beta defensin-2 levels predicted mortality, although there was a trend towards increased mortality with lower cathelicidin (p = 0.09).
Neither cathelicidin nor beta defensin-2 levels correlated with 25-hydroxyvitamin D.

Conclusions 25-hydroxyvitamin D deficiency is associated with increased mortality in patients admitted to hospital with community-acquired pneumonia during winter.
Contrary to our hypothesis, 25-hydroxyvitamin D levels were not associated with levels of cathelicidin or beta defensin-2.

 Download the PDF from VitaminDWiki

Vitamin D and bacteria pneumonia causality (ignores the Vitamin D Receptor) - March 2021

Vitamin D and bacterial pneumonias: the question of causality
Thorax. 2021 Mar 2;thoraxjnl-2020-216375. doi: 10.1136/thoraxjnl-2020-216375
Richard James Allen 1
 Download the PDF from VitaminDWiki

Type of Pneumonia: viral, bacterial, fungal

Scientific Animations
25% of Pneumonia is viral (Rhenovirus, Influenza, etc,) - CDC

High-dose Vitamin D reduces recurrent pneumonia by half - meta-analysis Oct 2020

Efficacy of High-Dose Vitamin D Supplementation as an Adjuvant Treatment on Pneumonia: Systematic Review and a Meta-Analysis of Randomized Controlled Studies
Nutrition Considerations for Specific Medical Conditions https://doi.org/10.1002/ncp.10585
Chao Yang MD, PhD, Yifei Lu MD, Min Wan MPH, Dengfeng Xu MD, PhD, Xian Yang MD, PhD, Ligang Yang MD, PhD

The purpose of this meta-analysis was to summarize randomized controlled trial (RCT) evidence and evaluate the efficacy and safety of vitamin D (VD) supplementation as an adjunct to antibiotics for the treatment of pneumonia. Data sources published from the inception dates up to January 2020 were searched. RCTs of VD supplementation of any duration, age, and dosing regimen type were eligible for inclusion if data on pneumonia were collected. Thirteen studies (4786 randomized participants) fulfilled eligibility criteria.
VD supplementation significantly increased levels of serum 25(OH)D (mean difference = 15.97; 95% CI, 7.49–24.44; P = .002) and reduced incidence of repeat episodes of pneumonia (risk ratio [RR] = 0.68; 95% CI, 0.50–0.93; P = .02).
Subgroup analysis revealed VD supplementation had more reducing effects on repeat episodes of pneumonia among participants in trials in which the population were children (RR = 0.66; 95% CI, 0.48–0.90), duration <3 months (RR = 0.55; 95% CI, 0.33–0.91), or
dose of VD <300,000 IU (RR = 0.51; 95% CI, 0.29–0.89).
Although our results suggested that VD supplementation had a positive effect on recovery rate of pneumonia (RR = 1.28; 95% CI, 0.94–1.74; I2 = 13%), there was no statistical difference (P = .12).
High-dose VD intervention may have an effect on reducing the incidence rate of repeat episodes of pneumonia by enhancing immune efficacy, although more population studies are needed to support that VD supplementation has therapeutic effects on pneumonia itself.
 Download the PDF from Sci-Hub via VitaminDWiki

36+ VitaminDWiki pages have PNEUMONIA in the title

Pneumonia problems in China might by treated by Vitamin A - Dr. Campbell Videos

Vitamin A and mystery pneumonia Dec 2023
Pneumonia and Vitamin A in China Dec 2023
Vitamin A deficiency is a problem in China, but not the US

See also: Vitamin D and Vitamin A - toxicity and interaction

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Created by admin. Last Modification: Sunday December 10, 2023 18:40:16 GMT-0000 by admin. (Version 85)
Pneumonia and low vitamin D - many studies        
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Attached files

ID Name Comment Uploaded Size Downloads
18976 Pneu meta sci-hub_CompressPdf.pdf admin 13 Dec, 2022 381.98 Kb 269
15158 bacteria pneumonia.jpg admin 03 Mar, 2021 57.46 Kb 1419
15157 Vitamin D and bacterial pneumonias causality.pdf admin 03 Mar, 2021 276.21 Kb 626
13532 Pneumonia 300,000 IU.pdf admin 24 Feb, 2020 143.25 Kb 842
13436 Pathogens-causing-pneumonia_180607_04.jpg admin 03 Feb, 2020 1,015.72 Kb 3697
13420 Pneumonia RCT 100,000.pdf admin 30 Jan, 2020 589.46 Kb 1043
13419 VIDCAPS RCT.pdf admin 30 Jan, 2020 1.05 Mb 1112
13418 Pneunomia meta 2019.pdf admin 30 Jan, 2020 773.80 Kb 1017
10908 Vitamin D, Innate Immunity and Outcomes in Community Acquired Pneumonia.pdf admin 26 Nov, 2018 296.43 Kb 1441