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Pneumonia Risk, intensity, and mortality all associated with low vitamin D

Pneumonia in VitaminDWiki

Risk Factor estimates for Pneumonia

Children and Pneumonia

Pneumonia in peer-reviewed medical publications (PubMed)

  • Effect of Adjunctive Single High-Dose Vitamin D 3 on Outcome of Community-Acquired Pneumonia in Hospitalised Adults: The VIDCAPS Randomised Controlled Trial - Sept 2018  Download the RCT PDF from VitaminDWiki
    • 17X more likely for Pneumonia to go away in those starting with <10 ng and getting a single dose of 200,000 IU of Vitamin D
    • Note: Not statistically significant
  • The Association Between Vitamin D Deficiency and Community-Acquired Pneumonia: A Meta-Analysis of Observational Studies - Sept 2019
  • Effect of Vitamin D Supplementation in the Prevention of Recurrent Pneumonia in Under-Five Children - Dec 2019,DOI: 10.1007/s12098-019-03025-z
  • Vitamin D Supplementation for Treatment and Prevention of Pneumonia in Under-five Children: A Randomized Double-blind Placebo Controlled Trial - Aug 2016  Download the RCT PDF from VitaminDWiki
    • 100,000 IU temporaily raised vitamin D levels by an average of 30 ng, not much benefit (needed much larger dose)

Pneumonia in the web

  • https://en.wikipedia.org/wiki/Pneumonia
    "Pneumonia affects approximately 450 million people globally (7% of the population) and results in about 4 million deaths per year"
    "Pneumonia often shortens suffering among those already close to death and has thus been called "the old man's friend"."
    "Pneumonia is due to infections caused primarily by bacteria or viruses and less commonly by fungi and parasites."
    "Conditions and risk factors that predispose to pneumonia include
    • smoking, immunodeficiency, alcoholism, chronic obstructive pulmonary disease, asthma, chronic kidney disease, and liver disease."
    • Note by VitaminDWiki - every one of those risk factors is also associated with low vitamin D levels
  • https://en.wikipedia.org/wiki/Community-acquired_pneumonia much less likely to be due to a superbug
  • Sunshine, rainfall, humidity and child pneumonia in the tropics: time-series analyses June 2013
    "Lack of sunshine was most strongly associated with pneumonia in both lagged regression. . . and case-crossover analysis"
    "This association is well known in temperate settings but has not been noted previously in the tropics"
  • Search Google for heliotherapy pneumonia 31,000 items
    sun therapy for pneumonia, TB, etc. was common before the invention of antibiotics
  • Be in the Know About Pneumonia Mercola June 2016?
    "These rates resulted in pneumonia being addressed as the eighth leading cause of death in the U.S., tied with influenza."
    ". . .it’s one of the two main causes of hospitalization, apart from childbirth."

Pneumonia elderly death 12X more likely when vitamin D less than 12 ng – 2011

Vitamin D, Innate Immunity and Outcomes in Community Acquired Pneumonia
1. Leong Leow1, 2. Talia Simpson3, 3. Ray Cursons3, 4. Noel Karalus1, 5. Robert J Hancox1,2,*
DOI: 10.1111/j.1440-1843.2011.01924.x
© 2011 The Authors. Respirology © 2011 Asian Pacific Society of Respirology, Respirology

Background and objective Vitamin D regulates the production of the antimicrobial peptides cathelicidin and beta defensin-2, which play an important role in the innate immune response to infection. We hypothesised that vitamin D deficiency would be associated with lower levels of these peptides and worse outcomes in patients admitted to hospital with community-acquired pneumonia.

Methods Associations between mortality and serum levels of 25-hydroxyvitamin D, cathelicidin, and beta defensin-2 were investigated in a prospective cohort of 112 patients admitted with community-acquired pneumonia during winter.

Results Severe 25-hydroxyvitamin D deficiency (<30nmol/L) was common in this population (15%) and was associated with a higher 30-day mortality compared to patients with sufficient 25-hydroxyvitamin D(>50nmol/L) (OR 12.7, 95%CI 2.2-73.3, p = 0.004).

These associations were not explained by differences in age, co-morbidities, or the severity of the acute illness.
Neither cathelicidin nor beta defensin-2 levels predicted mortality, although there was a trend towards increased mortality with lower cathelicidin (p = 0.09).
Neither cathelicidin nor beta defensin-2 levels correlated with 25-hydroxyvitamin D.

Conclusions 25-hydroxyvitamin D deficiency is associated with increased mortality in patients admitted to hospital with community-acquired pneumonia during winter.
Contrary to our hypothesis, 25-hydroxyvitamin D levels were not associated with levels of cathelicidin or beta defensin-2.

 Download the PDF from VitaminDWiki

Vitamin D and bacteria pneumonia causality (ignores the Vitamin D Receptor) - March 2021

Vitamin D and bacterial pneumonias: the question of causality
Thorax. 2021 Mar 2;thoraxjnl-2020-216375. doi: 10.1136/thoraxjnl-2020-216375
Richard James Allen 1
 Download the PDF from VitaminDWiki

Type of Pneumonia: viral, bacterial, fungal

Scientific Animations
25% of Pneumonia is viral (Rhenovirus, Influenza, etc,) - CDC

VitaminDWiki pages containing "pneumonia" in title (34 pages as of July 2021)

Items found: 34
Title Modified
Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT Oct 2010 01 Apr, 2021
Fewer children died of pneumonia after getting 100,000 IU of vitamin D – RCT March 2021 01 Apr, 2021
Acute pneumonia in children 3X less likely if greater than 30 ng of vitamin D – Jan 2021 20 Mar, 2021
Pneumonia Risk, intensity, and mortality all associated with low vitamin D 20 Mar, 2021
COVID-19 plus pneumonia in ICU with low vitamin D equaled Death - Dec 2020 04 Jan, 2021
Vitamin D supplementation could prevent and treat influenza, CORONAVIRUS, and pneumonia infections - March 2020 30 Mar, 2020
Spinal Cord Injured persons were 7.6 X more likely to get pneumonia if low vitamin D – Jan 2020 18 Jan, 2020
Pneumonia 6X more likely if very low vitamin D – meta-analysis Sept 2019 18 Oct, 2019
Hospital-acquired pneumonia treated by vitamin D if person was deficient – RCT Sept 2018 16 Sep, 2018
Pneumonia in Egyptian Children 3.6 X more likely if poor Vitamin D Receptor – Aug 2018 15 Aug, 2018
Childhood pneumonia not treated by 100,000 IU of vitamin D – Cochrane (need more, inhaled) – July 2018 19 Jul, 2018
Pneumonia is increasing (now 1 in 6 child deaths), more vitamin D studies needed – June 2018 09 Jun, 2018
RSV (bronchitis and viral pneumonia) in infants associated with low vitamin D and antibiotics – Aug 2015 10 Jan, 2018
Ventilator-associated pneumonia death rate cut in half by Vitamin D injection (300,000 IU) – RCT July 2017 06 Dec, 2017
Pneumonia patients 3 X more likely to die if low vitamin D – meta-analysis Sept 2017 07 Oct, 2017
Children with pneumonia in Ethiopia were 22X more likely to have rickets – 1997 25 Jun, 2017
Viral Pneumonia in children 52 X more-likely if very low vitamin D (trend) – June 2017 25 Jun, 2017
Any supplementation with vitamin D reduced chance of pneumonia by 50 percent – Oct 2013 25 Jun, 2017
Less Pneumonia in those having more activated vitamin D (kidneys working)– April 2014 25 Jun, 2017
Pneumonia acquired in hospital – 3X more likely to die if low vitamin D – June 2015 08 Jan, 2017
Pneumonia is less frequent in people with more than 35 ng of vitamin D – Nov 2013 26 Nov, 2016
Severe Pneumonia (CAP) results in death 2 times more often if very low vitamin D – July 2016 26 Nov, 2016
Pneumonia in children not stopped for 6 months by single dose of vitamin D (3 months max) – RCT Nov 2016 26 Nov, 2016
Season of birth associated with pneumonia (10 pcnt) and multiple sclerosis (30 pcnt) – May 2013 05 Nov, 2016
Pneumonia in seniors was 2.5X more likely if low vitamin D – June 2014 26 Jul, 2016
Animal study: vitamin D as an adjunct therapy for the treatment of Pneumocystis pneumonia - Jan 2015 05 Jan, 2016
Quarterly vitamin D3 is too infrequent – it increases the occurrence of pneumonia – June 2012 04 Jan, 2016
Much higher hospital costs (ICU and pneumonia) if low vitamin D – Dec 2015 03 Dec, 2015
Pneumonia 2.6X more likely if low vitamin D – April 2013 07 May, 2015
ICU patients with pneumonia stay 7 days longer if low vitamin D - Dec 2011 16 Nov, 2013
A little extra vitamin D did not reduce chance of pneumonia – July 2013 15 Oct, 2013
Rickets in 80 percent of infants with severe pneumonia – Sept 2010 23 Jun, 2013
2000 IU of vitamin D for just 5 days did not treat severe pneumonia – RCT June 2012 19 Jan, 2013
Pseudomonas pneumonia- April 2010 14 Apr, 2010

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Pneumonia Risk, intensity, and mortality all associated with low vitamin D        
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Attached files

ID Name Comment Uploaded Size Downloads
15158 bacteria pneumonia.jpg admin 03 Mar, 2021 14:13 57.46 Kb 301
15157 Vitamin D and bacterial pneumonias causality.pdf admin 03 Mar, 2021 14:08 276.21 Kb 130
13532 Pneumonia 300,000 IU.pdf admin 24 Feb, 2020 17:31 143.25 Kb 314
13436 Pathogens-causing-pneumonia_180607_04.jpg admin 03 Feb, 2020 11:32 1,015.72 Kb 1878
13420 Pneumonia RCT 100,000.pdf admin 30 Jan, 2020 03:24 589.46 Kb 498
13419 VIDCAPS RCT.pdf PDF 2019 admin 30 Jan, 2020 02:41 1.05 Mb 545
13418 Pneunomia meta 2019.pdf PDF 2019 admin 30 Jan, 2020 02:26 773.80 Kb 498
10908 Vitamin D, Innate Immunity and Outcomes in Community Acquired Pneumonia.pdf admin 26 Nov, 2018 02:32 296.43 Kb 860
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