- 4+ VitaminDWiki pages have BPH in the title
- BPH about 50% more likely if poor VDR – meta-analysis March 2024
- VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
- VitaminDWiki – Vitamin D Receptor category contains
- 55 health problems associated with poor VDR
- How to increase VDR activation
4+ VitaminDWiki pages have BPH in the title
This list is automatically updated
BPH about 50% more likely if poor VDR – meta-analysis March 2024
Association between vitamin D receptor gene polymorphisms and genetic susceptibility to benign prostatic hyperplasia: A systematic review and meta-analysis
Medicine (Baltimore) 2024 Mar 1;103(9):e37361. doi: 10.1097/MD.0000000000037361.
Li Ruan 1
Background: Benign prostatic hyperplasia (BPH) is one of the global public health challenges due to the complexity of its mechanisms of occurrence. Many studies have suggested that vitamin D receptor gene polymorphisms are associated with BPH susceptibility. Still, their conflicting findings need to be analyzed in aggregate to gain a better understanding.
Methods: We identified 10 trials involving 1539 BPH cases and 1915 controls through a systematic search of Embase using, data obtained from the Web of Science, PubMed, and China Knowledge Network databases as of December 31, 2021. A meta-analysis was performed to investigate the association between 4 constant polymorphisms of this associated vitamin D receptor gene (Fok-1, Bsm-1, Taq-1, and Apa-1) and BPH risk.
Results: In the overall population analysis, a significant positive association with BPH risk was found only in the Taq-1 variant (P < .001). Of these, the pure-hybrid model (95% confidence interval [CI] = 1.384-3.196), the heterozygous model (95% CI = 1.207-2.021), the dominant model (95% CI = 1.312-2.133) and the allelic inheritance model (95% CI = 1.205-1.730) showed low heterogeneity. In subtype analyses, Bsm-1 variants showed a significant association with BPH risk for both the recessive (95% CI = 0.100-0.943, P = .039) and over-dominant (95% CI = 1.553-3.100, P = 0) models in the Caucasian population, and for the recessive (95% CI = 1.242-3.283, P = .039) and over-dominant (95% CI = 0.281-0.680, P = 0) models in the Asian population. In addition, a high degree of heterogeneity was found in the subgroup analysis of the association between Fok-1 variants and BPH risk.
Conclusion: Overall, there is an association between vitamin D receptor polymorphisms and BPH risk. Identification of BPH susceptibility by vitamin D receptor gene polymorphisms has potential.
31 References
- Lerner LB, McVary KT, Barry MJ, et al. Management of lower urinary tract symptoms attributed to benign prostatic hyperplasia: AUA GUIDELINE PART I—initial work-up and medical management. J Urol. 2021;206:806–17.
- Devlin CM, Simms MS, Maitland NJ. Benign prostatic hyperplasia—what do we know? BJU Int. 2021;127:389–99.
- Qian XQ, Xu D, Liu HL, et al. Genetic variants in 5p13.2 and 7q21.1 are associated with treatment for benign prostatic hyperplasia with the alpha-adrenergic receptor antagonist. Aging Male. 2017;20:250–6.
- Na R, Helfand BT, Chen HT, et al. A genetic variant near GATA3 implicated in inherited susceptibility and etiology of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). prostate. 2017;77:1213–20.
- AlChalabi R, Wali MH, Al-Ugaili DN, et al. Association between single nucleotide polymorphisms of vitamin D receptor gene and diabetes with progression of benign prostatic hyperplasia. Ann Trop Med Public Health. 2020;23:444–54.
- Kayode OT, Owolabi AV, Kayode AAA. Biochemical and histomorphological changes in testosterone propionate-induced benign prostatic hyperplasia in male Wistar rats treated with ketogenic diet. Biomed Pharmacother. 2020;132:110863.
- Chaimuangraj S, Thammachoti R, Ongphiphadhanakul B, et al. Lack of association of VDR polymorphisms with Thai prostate cancer as compared with benign prostate hyperplasia and controls. Asian Pac J Cancer Prev. 2006;7:136–9.
- Manchanda PK, Konwar R, Nayak VL, et al. Association of genetic variants of the vitamin D receptor (VDR) gene (Fok-1, Taq-1 & Bsm-1) with susceptibility of benign prostatic hyperplasia in a North Indian population. Asian Pac J Cancer Prev. 2010;11:1005–8.
- Zeng XT, Yao QS, Weng H, et al. Meta-analysis of vitamin D receptor gene polymorphisms and benign prostatic hyperplasia risk. Mol Biol Rep. 2014;41:6713–7.
- Lu C, Zhou W, He X, et al. Vitamin D status and vitamin D receptor genotypes in celiac disease: a meta-analysis. Crit Rev Food Sci Nutr. 2021;61:2098–106.
- Barry EL, Peacock JL, Rees JR, et al. vitamin D receptor genotype, vitamin D3 supplementation, and risk of colorectal adenomas: a randomized clinical trial. JAMA Oncol. 2017;3:628–35.
- Latacz M, Rozmus D, Fiedorowicz E, et al. vitamin D receptor (VDR) gene polymorphism in patients diagnosed with colorectal cancer. Nutrients. 2021;13:200.
- Huang SP, Huang CY, Wu WJ, et al. Association of vitamin D receptor Fok-1 polymorphism with prostate cancer risk, clinicopathological features and recurrence of prostate specific antigen after radical prostatectomy. Int J Cancer. 2006;119:1902–7.
- Zhou Q, Wen S, Liu M, et al. Association between gene polymorphisms of vitamin D receptor and gestational diabetes mellitus: a systematic review and meta-analysis. Int J Environ Res Public Health. 2020;18:205.
- Bousemaa JT, Bussemakers MJG, Houwelingen KP, et al. Polymorphisms in the vitamin D receptor gene and the androgen receptor gene and the risk of benign prostatic hyperplasia. Eur Urol. 2000;37:234–8.
- El-Ezzi AA, Zaidan WR, El-Saidi MA, et al. Association of benign prostate hyperplasia with polymorphisms in VDR, CYP17, and SRD5A2 genes among Lebanese men. Asian Pac J Cancer Prev. 2014;15:1255–62.
- Zhang LL, Song Y, He LL, et al. Associations of SRD5A2/CYP17/CYP19/VDR gene polymorphisms with the development and clinical progression of benign prostatic hyperplasia: a case-control study in northern Chinese population. Int J Clin Exp Pathol. 2017;10:8660–76.
- Ruan L, Zhu JG, Pan C, et al. Association between single nucleotide polymorphism of vitamin D receptor gene Fok-1 polymorphism and clinical progress of benign prostatic hyperplasia. ScientificWorldJournal. 2015;2015:235895.
- Schatzl G, Gsur A, Bernhofer G, et al. Association of vitamin D receptor and 17 Hydroxylase Gene polymorphisms with benign prostatic hyperplasia and Benign prostatic enlargement. Urology. 2000;57:567–72.
- Habuchi T, Suzuki T, Sasaki R, et al. Association of vitamin D receptor gene polymorphism with prostate cancer and benign prostatic hyperplasia in a Japanese population. Cancer Res. 2000;60:305–8.
- Nunes SBR, Oliveira FM, Neves AF, et al. Association of vitamin D receptor variants with clinical parameters in prostate cancer. Springerplus. 2016;5:364.
- Hamasaki T, Inatomi H, Katoh T, et al. Significance of vitamin D receptor gene polymorphism for risk and disease severity of prostate cancer and benign prostatic hyperplasia in Japanese. Urol Int. 2002;68:226–31.
- Lee Ch L, Lee J, Na YJ, et al. Combined effect of polymorphisms in type III 5-α reductase and androgen receptor gene with the risk of benign prostatic hyperplasia in Korea. J Exerc Rehabil. 2016;12:504–8.
- Taheri M, Pouresmaeili F, Omrani MD, et al. Association of ANRIL gene polymorphisms with prostate cancer and benign prostatic hyperplasia in an Iranian population. Biomark Med. 2017;11:413–22.
- Manchanda PK, Kibler AJ, Zhang M, et al. vitamin D receptor as a therapeutic target for benign prostatic hyperplasia. Indian J Urol. 2012;28:377–81.
- Lin L, Li P, Liu X, et al. Systematic review and meta-analysis of candidate gene association studies of benign prostate hyperplasia. Syst Rev. 2022;11:60.
- Mullan RJ, Bergstralh EJ, Farmer SA, et al. Growth factor, cytokine, and vitamin D receptor polymorphisms and risk of benign prostatic hyperplasia in a community-based cohort of men. Urology. 2006;67:300–5.
- Kim SK, Chung JH, Park HC, et al. Association between polymorphisms of estrogen receptor 2 and benign prostatic hyperplasia. Exp Ther Med. 2015;10:1990–4.
- Swami S, Krishnan AV, Feldman D. Vitamin D metabolism and action in the prostate: implications for health and disease. Mol Cell Endocrinol. 2011;347:61–9.
- Ruiz-Ballesteros AI, Meza-Meza MR, Vizmanos-Lamotte B, et al. Association of vitamin D metabolism gene polymorphisms with autoimmunity: evidence in population genetic studies. Int J Mol Sci. 2020;21:9626.
- Brustad N, Greve JH, Mirzakhani H, et al. High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze. Pediatr Allergy Immunol. 2021;32:679–89.
VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, Berberine, intense exercise, Butyrate Sulforaphane Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators
VitaminDWiki – Vitamin D Receptor category contains
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
| Increasing | Increases |
| 1) Vitamin D supplement Sun Ultraviolet -B | Vitamin D in the blood and thus in the cells |
| 2) Magnesium | Vitamin D in the blood AND in the cells |
| 3) Omega-3 | Vitamin D in the cells |
| 4) Resveratrol | Vitamin D Receptor |
| 5) Intense exercise | Vitamin D Receptor |
| 6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
| 7) Quercetin (flavonoid) | Vitamin D Receptor |
| 8) Zinc is in the VDR | Vitamin D Receptor |
| 9) Boron | Vitamin D Receptor ?, etc |
| 10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
| 11) Progesterone | Vitamin D Receptor |
| 12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D Receptor |
| 13) Sulfroaphane and perhaps sulfur | Vitamin D Receptor |
| 14)Butyrate especially gut | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
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