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Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019

Both HUSS Publication and Dissertation are on this page

VitaminDWiki

It appears that Breast Cancer is able to protect itself by deactivating the Vitamin D Receptor

Items in both categories Breast Cancer and Vitamin D Receptor are listed here:

The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019
Vitamin D Receptor table shows what compensates for low VDR activation

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above


Vitamin D receptor expression in invasive breast tumors and breast cancer survival - July 2019

Breast Cancer Research volume 21, Article number: 84 (2019)
Linnea Huss, Salma Tunå Butt, Signe Borgquist, Karin Elebro, Malte Sandsveden, Ann Rosendahl & Jonas Manjer

 Download the Publication PDF from VitaminDWiki
Image

Background
Vitamin D has been suggested to prevent and improve the prognosis of several cancers, including breast cancer. We have previously shown a U-shaped association between pre-diagnostic serum levels of vitamin D and risk of breast cancer-related death, with poor survival in patients with the lowest and the highest levels respectively, as compared to the intermediate group. Vitamin D exerts its functions through the vitamin D receptor (VDR), and the aim of the current study was to investigate if the expression of VDR in invasive breast tumors is associated with breast cancer prognosis.

Methods
VDR expression was evaluated in a tissue microarray of 718 invasive breast tumors. Covariation between VDR expression and established prognostic factors for breast cancer was analyzed, as well as associations between VDR expression and breast cancer mortality.

Results
We found that positive VDR expression in the nuclei and cytoplasm of breast cancer cells was associated with favorable tumor characteristics such as smaller size, lower grade, estrogen receptor positivity and progesterone receptor positivity, and lower expression of Ki67. In addition, both intranuclear and cytoplasmic VDR expression were associated with a low risk of breast cancer mortality, hazard ratios 0.56 (95% CI 0.34–0.91) and 0.59 (0.30–1.16) respectively.

Conclusions
This study found that high expression of VDR in invasive breast tumors is associated with favorable prognostic factors and a low risk of breast cancer death. Hence, a high VDR expression is a positive prognostic factor.


Vitamin D and Breast Cancer. Studies on Incidence and Survival - dissertation

Huss, Linnea LU PHD Dissertation
 Download the Dissertation PDF from VitaminDWiki

Breast Cancer Survival if have low levels of Vitamin D at time of diagnosis
Image
Note: Increase survival if increase Vitamin D and/or increase VDR activation

Previous research has suggested beneficial effects of vitamin D on both breast cancer risk and prognosis. The overall aim of this research project was to investigate associations between vitamin D and breast cancer. The population-based prospective cohort, the Malmö Diet and Cancer Study, recruited 17,034 women in the first half of the 1990s. Studies in in the current thesis are based on blood samples collected at baseline, analyzed for levels of vitamin D, parathyroid hormone (PTH), calcium and later also used for genetic sequencing. Breast tumors that developed in women within the cohort were included in a tissue microarray and analyzed for expression of the vitamin D receptor (VDR).
Specific aims were to investigate:

  • I. Serum levels of vitamin D, PTH and calcium in relation to breast cancer survival, i.e. mortality among women diagnosed with breast cancer.
  • II. Vitamin D-related single nucleotide polymorphisms (SNPs) and breast cancer risk.
  • III. Expression of VDR in association with breast cancer mortality.
  • IV. Levels of vitamin D in relation to expression of VDR in subsequent breast tumors.

Results and conclusions:

  • I. Compared to intermediate levels of vitamin D, low levels and high levels were associated with a poor survival, i.e. high risk of death related to breast cancer. No association was found between PTH and breast cancer mortality. Relatively high serum calcium levels were associated with relatively low breast cancer mortality.
  • II. SNPs associated with levels of vitamin D did not affect breast cancer risk. One SNP, related to the vitamin D binding protein, was associated with breast cancer risk.
  • III. VDR expression was associated with a favorable breast cancer prognosis.
  • IV. There were indications that vitamin D levels were associated with VDR expression in a subsequent breast tumor.

The association between low vitamin D levels and high breast cancer mortality may be mediated through development of a VDR-negative tumor. There was no evidence to suggest an additional beneficiary effect of vitamin D levels higher than intermediate levels.

Title was revised July 2019 caused the visitor count to reset.
There have actually been 580 visitors to this page since it was originally made


Created by admin. Last Modification: Wednesday July 31, 2019 11:48:31 GMT-0000 by admin. (Version 12)

Attached files

ID Name Comment Uploaded Size Downloads
12403 BC survival VDR.jpg admin 29 Jul, 2019 19:28 40.87 Kb 12
12402 BC survival VDR.jpg admin 29 Jul, 2019 19:28 40.87 Kb 43
12401 BC VDR.pdf PDF 2019 admin 29 Jul, 2019 19:26 1.94 Mb 20
11800 Linnea Huss_web_compressed.pdf PDF 2019 admin 23 Apr, 2019 16:06 2.16 Mb 52
11799 BC low Vitamin D poor VDR.jpg admin 23 Apr, 2019 16:04 22.03 Kb 106
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