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Less vitamin D gets to cells as you age - fewer Vitamin D Receptors - 2004


Vitamin D Receptor Expression in Human Muscle Tissue Decreases With Age
HA Bischoff-Ferrari,1,2 M Borchers,3 F Gudat,4 U Du¨rmu¨ller,4 HB Sta¨helin,5 and W Dick1
heike.bischoff at usz.ch

 Download the PDF from VitaminDWiki

507 publications reference that study as of April 2019 some of which follow

  • Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials
  • Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
  • Vitamin D physiology - Lips
  • The vitamin D epidemic and its health consequences - Holick
  • Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta‐analysis
  • Vitamin D and human skeletal muscle
  • Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial
  • Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine
  • Recovery after unilateral knee replacement due to severe osteoarthritis and progression in the contralateral knee: a randomised clinical trial comparing daily …
  • The effect of vitamin D supplementation on lower-extremity power and function in older adults: a randomized controlled trial
  • Skeletal muscle performance and ageing
  • Non-musculoskeletal benefits of vitamin D
  • Variations in the vitamin D receptor gene are not associated with measures of muscle strength, physical performance, or falls in elderly men. Data from MrOS Sweden - 2019
  • Potential cellular and biochemical mechanisms of exercise and physical activity on the ageing process
  • The effect of vitamin D supplementation on lower-extremity power and function in older adults: a randomized controlled trial - 2019

Searched Google Scholar for "vitamin D receptor" (age OR elderly)

  • Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes - 2001
  • Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women - 1992
  • Quadriceps and Grip Strength Are Related to Vitamin D Receptor Genotype in Elderly Nonobese Women - 2009
  • Prediction of bone density from vitamin D receptor alleles - 1994
  • Association Between Intestinal Vitamin D Receptor, Calcium Absorption, and Serum 1,25 Dihydroxyvitamin D in Normal Young and Elderly Women - 2009
  • Are vitamin D receptor polymorphisms associated with bone mineral density? A meta‐analysis - 1996
  • Relationship between vitamin D receptor gene polymorphism and susceptibility to chronic kidney disease and periodontal disease in community‐dwelling elderly - 2018
  • The vitamin d receptor expression in skeletal muscle of women with distal radius fracture - June 2018

Vitamin D Receptor category in VitaminDWiki has the following

443 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 43 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (17 studies), Breast Cancer (19 studies), Colon Cancer (12 studies), Cardiovascular (20 studies), Cognition (15 studies), Diabetes (21 studies), Hypertension (5 studies), Infant (16 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (22 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (26 studies),   Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor VDR as of Oct 2019  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphane and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Health Problem
50Lyme Disease *
28Leprosy - another says 3X
15Chronic Heart Failure
15Temporary hair loss
14Hand, Foot, and Mouth disease
11Metabolic Syndrome
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
5Asthma Child see also 1.3, 2.0 and 3.6
4.6Breast Cancer * 16.9 X another study
4Polycystic ovary syndrome
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3 Waist size
3 Ischemic Stroke
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2 Wheezing/Asthma see also 5X
2 Melanoma   Non-melanoma Skin Cancers
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Childhood asthma see also 5X
1.3Psoriasis in Caucasians
?? Rickets - Vitamin D resistant

10 reasons why seniors need more vitamin D - includes Vitamin D Receptor

  1. Senior skin produces 3X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptors as they age
  3. Seniors are indoors more than than when they were younger
    • not as agile, weaker muscles; frail, no longer enjoy hot temperatures
    • (if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
  4. Seniors wear more clothing outdoors than when younger
    • Seniors also are told to fear skin cancer/wrinkles
  5. Seniors often take various drugs which reduce vitamin D
  6. Seniors often have one or more diseases which consume vitamin D
  7. Seniors generally put on weight at they age - and a heavier body requires more vitamin D
  8. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  9. Reduced stomach acid ==>less Magnesium needed to utilize vitamin D
    (would not show up on vitamin D test)
  10. Seniors with poorly functioning kidneys do not process vitamin D as well
    (would not show up on vitamin D test) 2009 full text online  Also PDF 2009
  11. Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)

Created by admin. Last Modification: Sunday April 28, 2019 23:21:21 GMT-0000 by admin. (Version 10)

Attached files

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8347 VDR decrease with age - 2004.jpg admin 25 Aug, 2017 20:06 26.21 Kb 452
8346 VDR decrease with age.jpg admin 25 Aug, 2017 20:05 19.75 Kb 434
8345 VDR Expression 2004.pdf PDF admin 25 Aug, 2017 20:05 583.83 Kb 487
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