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Less vitamin D gets to cells as you age - fewer Vitamin D Receptors - 2004

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Vitamin D Receptor Expression in Human Muscle Tissue Decreases With Age
HA Bischoff-Ferrari,1,2 M Borchers,3 F Gudat,4 U Du¨rmu¨ller,4 HB Sta¨helin,5 and W Dick1
heike.bischoff at usz.ch
JOURNAL OF BONE AND MINERAL RESEARCH Volume 19, Number 2, 2004

 Download the PDF from VitaminDWiki

507 publications reference that study as of April 2019 some of which follow

  • Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials
  • Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
  • Vitamin D physiology - Lips
  • The vitamin D epidemic and its health consequences - Holick
  • Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta‐analysis
  • Vitamin D and human skeletal muscle
  • Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial
  • Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine
  • Recovery after unilateral knee replacement due to severe osteoarthritis and progression in the contralateral knee: a randomised clinical trial comparing daily …
  • The effect of vitamin D supplementation on lower-extremity power and function in older adults: a randomized controlled trial
  • Skeletal muscle performance and ageing
  • Non-musculoskeletal benefits of vitamin D
  • Variations in the vitamin D receptor gene are not associated with measures of muscle strength, physical performance, or falls in elderly men. Data from MrOS Sweden - 2019
  • Potential cellular and biochemical mechanisms of exercise and physical activity on the ageing process
  • The effect of vitamin D supplementation on lower-extremity power and function in older adults: a randomized controlled trial - 2019

Searched Google Scholar for "vitamin D receptor" (age OR elderly)

  • Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes - 2001
  • Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women - 1992
  • Quadriceps and Grip Strength Are Related to Vitamin D Receptor Genotype in Elderly Nonobese Women - 2009
  • Prediction of bone density from vitamin D receptor alleles - 1994
  • Association Between Intestinal Vitamin D Receptor, Calcium Absorption, and Serum 1,25 Dihydroxyvitamin D in Normal Young and Elderly Women - 2009
  • Are vitamin D receptor polymorphisms associated with bone mineral density? A meta‐analysis - 1996
  • Relationship between vitamin D receptor gene polymorphism and susceptibility to chronic kidney disease and periodontal disease in community‐dwelling elderly - 2018
  • The vitamin d receptor expression in skeletal muscle of women with distal radius fracture - June 2018

Vitamin D Receptor category in VitaminDWiki has the following

299 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population has a poor VDR (40% of the Obese )

A poor VDR increases the risk of 53 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentation Vitamin D
Increases the concentration gradient
Vitamin D in the cells

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR

If poor Vitamin D Receptor

Risk
increase
Health Problem
50Lyme Disease
28Leprosy - another says 3X
15Chronic Heart Failure
13Sepsis
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
5Asthma Child see also 2.0 and 1.3
4.6Breast Cancer 16.9 X another study
4.1Vitiligo
4Polycystic ovary syndrome
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.3Autism
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma see also 5X
2 Melanoma   Non-melanoma Skin Cancers
2Myopia
2Preeclampsia
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.5Pertusus
1.5Obesity
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Childhood asthma see also 5X
1.3Psoriasis in Caucasians
1.3Tuberculosis
?? Rickets - Vitamin D resistant

10 reasons why seniors need more vitamin D - includes Vitamin D Receptor

  1. Senior skin produces 3X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptors as they age
    (The effect of low Vitamin D receptor genes does not show up on vitamin D test results)
  3. Seniors are indoors more than when when they were younger
    not as agile, weaker muscles; frail, no longer enjoy hot temperatures
    (if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
  4. Seniors wear more clothing outdoors than when younger
    fear skin cancer/wrinkles, sometimes avoid bright light after cataract surgery
  5. Seniors often take various drugs which reduce vitamin D (some would not show up on vitamin D test) statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
  6. Seniors often have one or more diseases which consume vitamin D ( osteoporosis, diabetes, MS, ...)
  7. Seniors generally put on weight at they age - and a heavier body requires more vitamin D
  8. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  9. Seniors not have as much Magnesium needed to use vitamin D
    (would not show up on vitamin D test)
  10. Seniors with poorly functioning kidneys do not process vitamin D as well
    (would not show up on vitamin D test) 2009 full text online  Also PDF 2009
  11. Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)

Created by admin. Last Modification: Sunday April 28, 2019 23:21:21 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
8347 VDR decrease with age - 2004.jpg admin 25 Aug, 2017 20:06 26.21 Kb 136
8346 VDR decrease with age.jpg admin 25 Aug, 2017 20:05 19.75 Kb 143
8345 VDR Expression 2004.pdf PDF admin 25 Aug, 2017 20:05 583.83 Kb 96
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