Vitamin D as a potential preventive agent for young women's breast cancer
Cancer Prevention Research, DOI: 10.1158/1940-6207.CAPR-21-0114
Sarah M Bernhardt, Virgina F Borges and Pepper Schedin schedin at ohsu.edu
Clinical studies backed by research in animal models suggest that vitamin D may protect against the development of breast cancer, implicating vitamin D as a promising candidate for breast cancer prevention.
However, despite clear pre-clinical evidence showing protective roles for vitamin D, broadly targeted clinical trials of vitamin D supplementation have yielded conflicting findings, highlighting the complexity of translating pre-clinical data to efficacy in humans.
While vitamin D supplementation targeted to high-risk populations is a strategy anticipated to increase prevention efficacy, a complimentary approach is to target transient, developmental windows of elevated breast cancer risk. Postpartum mammary gland involution represents a developmental window of increased breast cancer promotion that may be poised for vitamin D supplementation.
Targeting the window of involution with short-term vitamin D intervention may offer a simple, cost-effective approach for the prevention of breast cancers that develop postpartum. In this review, we highlight epidemiologic and preclinical studies linking vitamin D deficiency with breast cancer development.
We discuss the underlying mechanisms through which vitamin D deficiency contributes to cancer development, with an emphasis on the anti-inflammatory activity of vitamin D. We also discuss current evidence for vitamin D as an immunotherapeutic agent and the potential for vitamin D as a preventative strategy for young woman's breast cancer
Section Titles
Overview of Vitamin D
Vitamin D signaling in breast cancer
Vitamin D in breast cancer progression and metastasis
Anti-inflammatory actions of vitamin D within the tumor microenvironment
Vitamin D as a therapeutic for the prevention of breast cancer
Targeting vitamin D to high-risk populations
Future research directions
Conclusion
There is strong evidence that downregulation of vitamin D signaling contributes to the development and progression of breast cancer. Epidemiological studies have linked vitamin D deficiency with an increased risk of breast cancer development; observations that are well-supported by research in animal models. However, while the potential for vitamin D as a breast cancer preventative agent is well-backed by pre-clinical data, clinical trials of vitamin D supplementation have produced modest and/or conflicting results. Vitamin D supplementation during transient, developmental windows of elevated risk may instead offer a more effective approach for the prevention of breast cancer. Post- lactational involution represents a key developmental window that may be poised for vitamin D supplementation. The unique demands for vitamin D during pregnancy and lactation emphasize vitamin D deficiency during the postpartum period, which in the background of the pro-inflammatory microenvironment of the involuting gland may enhance the tumor promotional attributes of involution. Attenuation of the inflammatory microenvironment of the vitamin D-deficient involuting breast with short-term vitamin D supplementation may offer protection against the development of postpartum breast cancer. Further research into the protective role of vitamin D against postpartum breast cancer development and progression is warranted.
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Note: This study indicates that Breast gets semiactivated Vitamin D p from the liver. Other studies indicate that the liver is not needed
Activating the Vitamin D Receptor increases Vitamin D
CYP27B1 increases Vitamin D
CYP24A1 decreases Vitamin D
Overview Breast Cancer and Vitamin D contains:
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24 Meta-analyses of Vitamin D and Breast Cancer
example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
wonder just how much more proof is needed- Breast Cancer 4X more likely if have poor genes
- Cancer - Breast category listing has
248 items along with related searches - Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
- Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
- Vitamin D both prevents and treats Breast Cancer – 2019
Getting Vitamin D into your body contains:
CYP27B1 category listing contains:
The CYP27B1 gene activates Vitamin D in the Kidney, Skin, Lungs, Brain, Eyes Breasts etc.
CYtochrome P450 family 27 subfamily B member 1 = 25-Hydroxyvitamin D3 1-alpha-hydroxylase58 items in CYP27B1 category 327 articles in the Genetics 499 articles in Vitamin D Receptor 174 articles in Vitamin D Binding Protein - CYP27B1 and other genes are less activated in seniors
- CYP27B causes many health problems – March 2020
- Every Parkinson’s brain had a poor CYP27B1 gene
Vitamin D blood test misses CYP27B1 and other genes
Cancers might alter CYP24A1 gene
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators
Items in both categories Vitamin D Receptor and Cancer - Breast:
- Breast cancer spreads to bone if poor vitamin D Receptor (no surprise) – Oct 2022
- Some breast cancers may be treated RNA changes caused by Vitamin D – March 2022
- Breast Cancer, Vitamin D, and genes – Welsh Nov 2021
- After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021
- Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021
- Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019
- After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019
- Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019
- Breast Cancer and Vitamin D review – March 2018
- Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Two chemicals increase the Vitamin D receptor and decrease the growth of breast cancer cells in the lab - March 2018
- Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies
- Vitamin D receptor as a target for breast cancer therapy (abstract only) – Feb 2017
- Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016
- Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- Vitamin D receptor in breasts and breast cancer vary with race – March 2013
- Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012
- Genes breast cancer and vitamin D receptor - Sept 2010
Thus, the breasts try to increase receptor activation and Cancer cells try to decrease activation
- Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010 chart shows gene changes with breast Cancer
Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 20212699 visitors, last modified 10 Jul, 2021, This page is in the following categories (# of items in each category)Attached files
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- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer