Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021

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Vitamin D as a potential preventive agent for young women's breast cancer

Cancer Prevention Research, DOI: 10.1158/1940-6207.CAPR-21-0114
Sarah M Bernhardt, Virgina F Borges and Pepper Schedin schedin at ohsu.edu

Clinical studies backed by research in animal models suggest that vitamin D may protect against the development of breast cancer, implicating vitamin D as a promising candidate for breast cancer prevention.

However, despite clear pre-clinical evidence showing protective roles for vitamin D, broadly targeted clinical trials of vitamin D supplementation have yielded conflicting findings, highlighting the complexity of translating pre-clinical data to efficacy in humans.

While vitamin D supplementation targeted to high-risk populations is a strategy anticipated to increase prevention efficacy, a complimentary approach is to target transient, developmental windows of elevated breast cancer risk. Postpartum mammary gland involution represents a developmental window of increased breast cancer promotion that may be poised for vitamin D supplementation.

Targeting the window of involution with short-term vitamin D intervention may offer a simple, cost-effective approach for the prevention of breast cancers that develop postpartum. In this review, we highlight epidemiologic and preclinical studies linking vitamin D deficiency with breast cancer development.

We discuss the underlying mechanisms through which vitamin D deficiency contributes to cancer development, with an emphasis on the anti-inflammatory activity of vitamin D. We also discuss current evidence for vitamin D as an immunotherapeutic agent and the potential for vitamin D as a preventative strategy for young woman's breast cancer

Section Titles
Overview of Vitamin D
Vitamin D signaling in breast cancer
Vitamin D in breast cancer progression and metastasis
Anti-inflammatory actions of vitamin D within the tumor microenvironment
Vitamin D as a therapeutic for the prevention of breast cancer
Targeting vitamin D to high-risk populations
Future research directions

Conclusion

There is strong evidence that downregulation of vitamin D signaling contributes to the development and progression of breast cancer. Epidemiological studies have linked vitamin D deficiency with an increased risk of breast cancer development; observations that are well-supported by research in animal models. However, while the potential for vitamin D as a breast cancer preventative agent is well-backed by pre-clinical data, clinical trials of vitamin D supplementation have produced modest and/or conflicting results. Vitamin D supplementation during transient, developmental windows of elevated risk may instead offer a more effective approach for the prevention of breast cancer. Post- lactational involution represents a key developmental window that may be poised for vitamin D supplementation. The unique demands for vitamin D during pregnancy and lactation emphasize vitamin D deficiency during the postpartum period, which in the background of the pro-inflammatory microenvironment of the involuting gland may enhance the tumor promotional attributes of involution. Attenuation of the inflammatory microenvironment of the vitamin D-deficient involuting breast with short-term vitamin D supplementation may offer protection against the development of postpartum breast cancer. Further research into the protective role of vitamin D against postpartum breast cancer development and progression is warranted.

 Download the PDF from VitaminDWiki

Note: This study indicates that Breast gets semiactivated Vitamin D p from the liver. Other studies indicate that the liver is not needed

Activating the Vitamin D Receptor increases Vitamin D

CYP27B1 increases Vitamin D

CYP24A1 decreases Vitamin D

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Overview Breast Cancer and Vitamin D contains:

• 25 Meta-analyses of Vitamin D and Breast Cancer
    example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.
• Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
     wonder just how much more proof is needed
• Breast Cancer 4X more likely if have poor genes
•     Cancer - Breast category listing has 263 items along with related searches
• Breast Cancer treatment – Vitamin D was the most-popular supplement – Jan 2023
• Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
• Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
• Vitamin D both prevents and treats Breast Cancer – 2019

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Getting Vitamin D into your blood and cells contains:

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CYP27B1 category listing contains:

The CYP27B1 gene activates Vitamin D in the Kidney,    Skin,    Lungs,    Brain,   Eyes   Breasts   etc.
Poor CYP27B1 is assocated with COVID, Miscarriage,   Lupus,   Alz, Parkinson, MSA,   Rickets

CYtochrome P450 family 27 subfamily B member 1    = 25-Hydroxyvitamin D3 1-alpha-hydroxylase

• 64 items in CYP27B1 category
• 346 articles in the Genetics
• 541 articles in Vitamin D Receptor
• 178 articles in Vitamin D Binding Protein
• CYP27B1 and other genes are less activated in seniors
• CYP27B causes many health problems – March 2020
• Every Parkinson’s brain had a poor CYP27B1 gene

What can be done if have a poor CYP27B1

• Larger doses of Vitamin D
• More Bio-available: Gut-friendly form, Topical form, taken with fatty meal, taken with evening meal
• Additional sources: UV
• Increase Vitamin D metabolism: additional Magnesium, Omega-3
  • All cytochrome P450 enzymes require Mg++ as a cofactor
• Increase the amount of Vitamin D in the blood that gets to cells: increase activation of VDR
  • See: Reasons for low response to vitamin D

Vitamin D blood test misses CYP27B1 and other genes

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Cancers might alter CYP24A1 gene

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The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

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VitaminDWiki - Vitamin D Receptor activation can be increased in many ways

Resveratrol,  Omega-3,   Magnesium,  Zinc,   Quercetin,   non-daily Vit D,   Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane  Metflormin (Kidney)   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the many VDR activators

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Items in both categories Vitamin D Receptor and Cancer - Breast:

Thus, the breasts try to increase receptor activation and Cancer cells try to decrease activation

• Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010 chart shows gene changes with breast Cancer
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