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Immunological effects of vitamin D and their relations to autoimmunity – March 2019

J Autoimmun. 2019 Mar 7. pii: S0896-8411(19)30033-2. doi: 10.1016/j.jaut.2019.03.002.
Yamamoto E1, Jørgensen TN2.

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Animal Model of Autoimmunity
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Vitamin D deficiency is an established risk factor for many autoimmune diseases and the anti-inflammatory properties of vitamin D underscore its potential therapeutic value for these diseases. However, results of vitamin D3 supplementation clinical trials have been varied. To understand the clinical heterogeneity, we reviewed the pre-clinical data on vitamin D activity in four common autoimmune diseases:

  • multiple sclerosis (MS),
  • rheumatoid arthritis (RA),
  • systemic lupus erythematosus (SLE), and
  • inflammatory bowel disease (IBD),

in which patients are commonly maintained on oral vitamin D3 supplementation. In contrast, many pre-clinical studies utilize other methods of manipulation (i.e. genetic, injection). Given the many actions of vitamin D3 and data supporting a vitamin D-independent role of the Vitamin D receptor (VDR), a more detailed mechanistic understanding of vitamin D3 activity is needed to properly translate pre-clinical findings into the clinic. Therefore, we assessed studies based on route of vitamin D3 administration, and identified where discrepancies in results exist and where more research is needed to establish the benefit of vitamin D supplementation.


See also VitaminDWiki

Items in both categories Lupus and Vitamin D Receptor are listed here:

Items in both categories Autoimmune and Vitamin D Receptor are listed here:

Created by admin. Last Modification: Saturday October 5, 2019 12:08:33 GMT-0000 by admin. (Version 5)

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11610 Autoimmunity animal.jpg admin 19 Mar, 2019 20:54 36.96 Kb 125
11609 Autoimmunity Sci-Hub.pdf PDF 2019 admin 19 Mar, 2019 20:50 1.42 Mb 67
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