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1289 genes changed with higher doses of Vitamin D - RCT Dec 2019

Disassociation of Vitamin D's Calcemic Activity and non-calcemic Genomic Activity and Individual Responsiveness: A Randomized controlled Double-Blind clinical Trial

Scientific RepoRtS | (2019) 9:17685 | https://doi.org/10.1038/s41598-019-53864-1
Arash Shirvani ,tyler Arek Kalajian, Anjeli Song & Michael F. Holick*


Randomized Controlled Trial lasting 24 weeks with 30 healthy adults of mixed race and sex

See also VitaminDWik

Genes and Pregnancy

Genes and MS

Future Vitamin D gene studies could examine the gene changes:

  • to the 35+ genes associated with Vitamin D
    • Vitamin D Receptor, Vitamin D Binding Protein, etc.
  • If also use any of the 12+ Vitamin D Receptor activators - such as Resveratrol
  • Associated with the immune system
  • In tissues rather than just the blood
  • Gut genes
  • If start RCT with low levels of vitamin D
  • If use infrequent dosing (non-daily)
  • If use UVB instead of Vitamin D
  • If the person has specific health problems
  • If have a poor vitamin D response
  • If add co-factors, e.g. Magnesium and Omega-3
  • If use a loading dose

Graphic of the study results by Dr. Raimund von Helden
Graphic and web page in German
Title translated from German: Vitamin D commands over 1200 genes - but only at a vitamin D level of 78 ng / ml
Graphics by GRH: 8X more genes changed

Vitamin D Receptor

Vitamin D Receptor category has the following

516 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14) Butyrate especially gutVitamin D Receptor
15) BerberineVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

10+ Vitamin D Receptor studies have overlaps to Health Problems

  • VDR & Diabetes 24 studies
  • VDR & Breathing 24 studies
  • VDR & Breast Cancer 22 studies
  • VDR & Cancer - general 23 studies
  • VDR & Obesity 17 studies
  • VDR &Multiple Sclerosis 24 studies

Vitamin D Binding Protein

MS and Vitamin D Binding Protein:

TB and Vitamin D Binding Protein:

Breathing and Vitamin D Binding Protein:

Infant-Child and Vitamin D Binding Protein:

Pregnancy and Vitamin D Binding Protein:

 Download the PDF from VitaminDWiki

The aims of this randomized controlled double-blind clinical trial were to assess the impact of vitamin D supplementation on calcium metabolism and non-calcemic broad gene expression by relating them to the individual's responsiveness to varying doses of vitamin D3. thirty healthy adults were randomized to receive 600, 4,000 or 10,000 IU/d of vitamin D3 for 6 months. Circulating parathyroid hormone (PTH), 25(OH)D, calcium and peripheral white blood cells broad gene expression were evaluated. We observed a dose-dependent increase in 25(OH)D concentrations, decreased PTH and no change in serum calcium. A plateau in PTH levels was achieved at 16 weeks in the 4000 and 10,000 IU/d groups. There was a dose-dependent 25(OH)D alteration in broad gene expression with 162, 320 and 1289 genes up- or down-regulated in their white blood cells, respectively. our results clearly indicated that there is an individual's responsiveness on broad gene expression to varying doses of vitamin D3. Vitamin D3 supplementation at 10,000 IU/d produced genomic alterations several fold higher than 4,000 IU/d even without further changes in PTH levels. Our findings may help explain why there are some inconsistency in the results of different vitamin D's clinical trials.

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Attached files

ID Name Comment Uploaded Size Downloads
14582 GRH 8X more genes changed.jpg admin 16 Nov, 2020 159.41 Kb 665
13107 Disassoc - chart.jpg admin 07 Dec, 2019 111.36 Kb 1124
13106 Vit D calcemic compressed.pdf admin 07 Dec, 2019 881.28 Kb 721