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Many health risks associated with low Vit D or poor Vitamin D Receptor – more RCT needed – March 2018

Health Risks of Hypovitaminosis D: A Review of New Molecular Insights

Int. J. Mol. Sci. 2018, 19, 892; doi:10.3390/ijms19030892
Daniela Caccamo dcaccamo at unime.it, Sergio Ricca, Monica Currò and Riccardo Ientile
Department of Biomedical Sciences, Dental Sciences, and Morpho-functional Imaging, University of Messina, 98125 Messina, Italy; ricca.sergio85 at gmail.com (S.R.); monica.curro at unime.it (M.C.); ientile at unime.it (R.I.)

VitaminDWiki
  • Paper correctly believes that Vitamin D prevents/treats many health problems
    • but that Vitamin D has a problem of increasing Calcium in the body
  • Their goal is to invent expensive Vitamin D analogs which might not increase Calcium
  • Far lower cost solutions which have been used for over a decade include:
  1. Reduce Calcium intake and Increase water to flush the Calcium out of the body
  2. Increase Vitamin K2 to decrease excess Calcium from being deposited where it is harmful

Genetics has a chart which show the VDR and CYP27B1 (and 3 others not seen by Vitamin D test)

Blood Test Misses a lot (VDW 3439)

Vitamin D Receptor category has the following

276 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population has a poor VDR (40% of the Obese )

A poor VDR increases the risk of 52 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation.
You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR

If poor Vitamin D Receptor

Risk
increase
Health Problem
15Chronic Heart Failure
13Sepsis
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
4.6Breast Cancer 16.9 X another study
4.1Vitiligo
4Polycystic ovary syndrome
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
3Leprosy - another says 28X
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.3Autism
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma
2 Melanoma   Non-melanoma Skin Cancers
2Myopia
2Preeclampsia
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.5Pertusus
1.5Obesity
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Childhood asthma
1.3Psoriasis in Caucasians
1.3Tuberculosis
?? Rickets - Vitamin D resistant

 Download the PDF from VitaminDWiki

Image
Image

Hypovitaminosis D has become a pandemic, being observed in all ethnicities and age groups worldwide. Environmental factors, such as increased air pollution and reduced ultraviolet B (UVB) irradiation, as well as lifestyle factors, i.e., decreased outdoor activities and/or poor intake of vitamin D-rich food, are likely involved in the etiology of a dramatic reduction of vitamin D circulating levels. The insufficiency/deficiency of vitamin D has long been known for its association with

  • osteoporosis and
  • rickets.

However, in the last few decades it has become a serious public health concern since it has been shown to be independently associated with various chronic pathological conditions such as

  • cancer,
  • coronary heart disease,
  • neurological diseases,
  • type II diabetes,
  • autoimmune diseases,
  • depression, with
  • various inflammatory disorders, and with
  • increased risk for all-cause mortality in the general population.

Prevention strategies for these disorders have recently involved supplementation with either vitamin D2 or vitamin D3 or their analogs at required daily doses and tolerable upper-limit levels. This review will focus on the emerging evidence about non-classical biological functions of vitamin D in various disorders.

Conclusions and Perspectives (from PDF)

In recent years, thousands of VDRE sites on the DNA sequence have been identified. Given the almost ubiquitous expression of VDR and CYP27B1, a great effort still has to be made to characterize molecular pathways regulated through genomic and non-genomic actions of this vitamin. Moreover, it is also very important to look for strategies to target specific cells with vitamin D analogs that do not display adverse side effects, such as increased intestinal calcium absorption and/or bone resorption. At present, analogs have been developed only for the therapeutic management of osteoporosis, hyperparathyroidism, and skin hyperproliferative disorders [10]. However, there is still a great demand for solid data from randomized clinical trials aimed at the treatment/prevention of cancer, CVD, neurodegenerative disorders, infections, and autoimmune diseases.
Findings from genome-wide analyses suggest the occurrence of several variants of key proteins of vitamin D metabolism that may affect circulating concentrations of vitamin D metabolites. These proteins include VDR, DBP, and 7-dehydrocholesterol synthase [6].
It is reasonable to expect in the near future that these protein variants will be in vivo detected and the above cited issues will be overcome, so that the management of disorders developing in association with vitamin D deficiency will be greatly improved.

Created by admin. Last Modification: Tuesday September 18, 2018 17:35:42 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
10564 189Health_Risks_of_Hypovitaminosis_D_A_Review_Caccamo.pdf PDF 2018 admin 18 Sep, 2018 17:02 856.08 Kb 22
10563 VDR.jpg admin 18 Sep, 2018 17:01 114.40 Kb 39
10562 Activation.jpg admin 18 Sep, 2018 17:00 21.19 Kb 36
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