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Frequent miscarriage associated with both lower vitamin D and poor Vitamin D receptor – Sept 2017

Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface.

Braz J Med Biol Res. 2017 Sep 12;50(11):e6527. doi: 10.1590/1414-431X20176527.
Li N1, Wu HM1, Hang F1, Zhang YS2, Li MJ1.

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Vitamin D levels


Poor Receptor levels in those with frequent miscarriages


Immunological mechanisms have been proposed to underlie the pathogenesis of recurrent spontaneous abortion (RSA). Vitamin D has a potent immunomodulatory effect, which may affect pregnancy outcome. The objective of this study was to investigate 25-hydroxyvitamin D [25(OH) D] concentration and vitamin D receptor (VDR) expression in the decidual tissues of RSA patients. Thirty women with RSA (RSA group) and thirty women undergoing elective abortion (control group) were recruited during 2016 from gynecology outpatient clinics. We measured 25(OH) D, interleukin (IL)-17, IL-23, transforming growth factor β (TGF-β), VDR and 1-α-hydroxylase (CYP27B1) in decidual tissues collected during the abortion procedure. In the RSA group, 25(OH) D and TGF-β were significantly decreased while IL-17 and IL-23 were significantly increased compared with the control group.
VDR expression was significantly decreased in the RSA group compared with the control group. Logistic regression analysis showed a significant negative correlation between 25(OH) D in decidual tissues and RSA. These results indicated that vitamin D concentrations in the decidua are associated with inflammatory cytokine production, suggesting that vitamin D and VDR may play a role in the etiology of RSA.

PMID: 28902929 DOI: 10.1590/1414-431X20176527

Created by admin. Last Modification: Friday April 5, 2019 12:58:56 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
8428 miscarriage VDR.jpg admin 14 Sep, 2017 8.97 Kb 596
8427 miscarriage.jpg admin 14 Sep, 2017 18.43 Kb 581
8426 recurrent spontaneous abortion - low D and poor VDR.pdf admin 14 Sep, 2017 761.69 Kb 599