Effects of resveratrol on bone health in type 2 diabetic patients. A double-blind randomized-controlled trial.
Nutr Diabetes. 2018 Sep 20;8(1):51. doi: 10.1038/s41387-018-0059-4.
Bo S1, Gambino R2, Ponzo V2, Cioffi I3, Goitre I2, Evangelista A4, Ciccone G4, Cassader M2, Procopio M2.
1 Department of Medical Sciences, University of Turin, Turin, Italy. simona.bo at unito.it.
2 Department of Medical Sciences, University of Turin, Turin, Italy.
3 Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy.
4 Unit of Clinical Epidemiology, CPO, "Città della Salute e della Scienza" Hospital of Turin, Turin, Italy.
- The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells, such as bone cells.
- Resveratrol is one of 7 ways to negate the Vitamin D Receptor restrictions
- This study found that increasing Resveratrol stopped bone loss
- Probably by getting more Vitamin D to the bone cells
BMD would have been improved even more if the elements known to be needed for building bones were also added:
Vitamin D, Magnesium, Vitamin K2, Boron, Silica, Exercise
- Adding just vitamin D again failed to add bone density (also need Magnesium, Vitamin K, etc) – RCT Aug 2018
- Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
- Better bones again associated with higher vitamin K intake – Nov 2015
- Strong bones need both physical activity and vitamin D – Jan 2013
- Bone formation in the lab is aided by Vitamin D, Vitamin K1, and Vitamin K2 – meta-analysis Nov 2017
- Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014
- Bone - Health category listing has
300 items along with related searches
- Resveratrol improves health (Vitamin D receptor, etc.)
Vitamin D Receptor category has the following
495 studies in Vitamin D Receptor category
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problemsSee also:
A poor VDR restricts Vitamin D from getting in the cells
47 studies in the Resveratrol category
It appears that 30% of the population have a poor VDR (40% of the Obese )Health problems include: Autoimmune (
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems
18 studies), Breast Cancer ( 20 studies), Colon Cancer ( 13 studies), Cardiovascular ( 23 studies), Cognition ( 16 studies), Diabetes ( 23 studies), Hypertension ( 9 studies), Infant ( 21 studies), Lupus ( 6 studies), Metabolic Syndrome ( 3 studies), Mortality ( 4 studies), Multiple Sclerosis ( 11 studies), Obesity ( 15 studies), Pregnancy ( 24 studies), Rheumatoid Arthritis ( 10 studies), TB ( 8 studies), VIRUS ( 33 studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
Compensate for poor VDR by increasing one or more:
Increasing Increases 1) Vitamin D supplement Sun
Vitamin D in the blood
and thus in the cells
2) Magnesium Vitamin D in the blood
AND in the cells
3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor 14)Butyrate especially gut Vitamin D Receptor
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
Patients with type 2 diabetes (T2DM) are at increased fracture risk. Resveratrol has shown beneficial effects on bone health in few studies. The aim of this trial was to investigate the effects of resveratrol on bone mineral density (BMD) and on calcium metabolism biomarkers in T2DM patients.
In this double-blind randomized placebo-controlled trial 192 T2DM outpatients were randomized to receive resveratrol 500 mg/day (Resv500 arm), resveratrol 40 mg/day (Resv40 arm) or placebo for 6 months. BMD, bone mineral content (BMC), serum calcium, phosphorus, alkaline phosphatase, and 25-hydroxy vitamin D were measured at baseline and after 6 months.
At follow-up, calcium concentrations increased in all patients, while within-group variations in alkaline phosphatase were higher in both resveratrol arms, and 25-hydroxy vitamin D increased in the Resv500 arm only, without between-group differences. Whole-body BMD significantly decreased in the placebo group, while whole-body BMC decreased in both the placebo and Resv40 arms. No significant changes in BMD and BMC values occurred in the Resv500 arm. The adjusted mean differences of change from baseline were significantly different in the Resv500 arm vs placebo for whole-body BMD (0.01 vs -0.03 g/cm2, p = 0.001), whole-body BMC (4.04 vs -58.8 g, p < 0.001), whole-body T-score (0.15 vs -0.26), and serum phosphorus (0.07 vs -0.01 µmol/L, p = 0.002). In subgroup analyses, in Resv500 treated-patients BMD values increased to higher levels in those with lower calcium and 25-hydroxy vitamin D values, and in alcohol drinkers.
Supplementation with 500 mg resveratrol prevented bone density loss in patients with T2DM, in particular, in those with unfavorable conditions at baseline.Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT Sept 2018
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