Loading...
 
Toggle Health Problems and D

Poor male fertility is association with poor Vitamin D Receptor (less D to the cells) – July 2021

Assessment of serum vitamin D level and seminal vitamin D receptor gene methylation in a sample of Egyptian men with idiopathic infertility

Andrologia . 2021 Jul 1;e14172. doi: 10.1111/and.14172
Tarek M Hussein 1, Nermeen Eldabah 2, Hadil A Zayed 1, Rasha M Genedy 1

VitaminDWiki

Fertility and Sperm category contains the following summary

117 items in Fertility or Sperm in VitaminDWiki

See also

Overview Women and Vitamin D
Overview Pregnancy and vitamin D    Fertility and Vitamin D – several articles
Endometriosis
Ensure a healthy pregnancy and baby - take Vitamin D before conception
Search VitaminDWiki for IVF OR "IN VITRO FERTILIZATION" 345 items as of Sept 2019
Search VitaminDWiki for "Assisted reproduction" 177 items as of Sept 2019
Search VitaminDWiki for "polycystic ovary syndrome" OR PCOS" Sept 2019
Search VitaminDWiki fore Testosterone 77 items just in webpages as of Sept 2020
Search VitaminDWiki for "erectile dysfunction" 120 items as of July 2018
Conception and vitamin D snapshot as of 2012

Vitamin D greatly improves Fertility

Increased male Vitamin D increases fertility


Items in both categories Fertility/sperm and Vitamin D Receptor:

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators


Vitamin D deficiency has been linked with different health problems including male infertility. Its function is mediated by the vitamin D receptor, which acts as a transcription factor. Epigenetic mechanisms such as DNA methylation may affect the vitamin D receptor gene and result in gene silencing. The present study aimed to assess serum vitamin D level and seminal methylation of vitamin D receptor gene in idiopathic male infertility. Blood and semen samples were collected from 60 men with idiopathic infertility and 40 healthy fertile men. Vitamin D levels were detected using enzyme-linked fluorescent assay technique and methylation status was assessed by methylation-specific PCR. Results revealed that serum levels of 25OHD were significantly lower in patients compared to controls. Positive correlation was found between serum level of 25OHD and sperm concentration in patients group and progressive motility in total studied group. Methylation of vitamin D receptor gene was significantly higher in patients compared to control group. Negative correlation was found between methylation of vitamin D receptor gene and both sperm concentration and progressive motility in total studied group. Results of the present study suggest that vitamin D deficiency and vitamin D receptor gene methylation may be involved in aetiopathogenesis of idiopathic male infertility.

REFERENCES

  • Abbasihormozi, S., Kouhkan, A., Alizadeh, A. R., Shahverdi, A. H., Nasr-Esfahani, M. H., Sadighi Gilani, M. A., Salman Yazdi, R., Matinibehzad, A., & Zolfaghari, Z. (2017). Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men. Andrology, 5(1), 113-118. https://doi.org/10.1111/andr.12280
  • Albaldawy, M. T., & Alsalami, A. S. (2017). Study of association among Vitamin D, testosterone and semen quality in fertile and Iraqi infertile men. Journal of Pharmaceutical Sciences and Research, 9(7), 1067.
  • Alzoubi, A., Mahdi, H., Al Bashir, S., Halalsheh, O., Al Ebbini, M., Alzarir, M., Al-Ahmar, K., Alfaqih, M., & Al-Hadidi, A. H. (2017). Normalization of serum vitamin D improves semen motility parameters in patients with idiopathic male infertility. Acta Endocrinologica (Bucharest), 13(2), 180-187. https://doi.org/10.4183/aeb.2017.180
  • Anagnostis, P., Karras, S., & Goulis, D. G. (2013). Vitamin D in human reproduction: A narrative review. International Journal of Clinical Practice, 67(3), 225-235. https://doi.org/10.1111/ijcp.12031
  • Blomberg Jensen, M., Bjerrum, P. J., Jessen, T. E., Nielsen, J. E., Joensen, U. N., Olesen, I. A., Petersen, J. H., Juul, A., Dissing, S., & Jørgensen, N. (2011). Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Human Reproduction (Oxford, England), 26(6), 1307-1317. https://doi.org/10.1093/humrep/der059
  • Blomberg Jensen, M., Gerner Lawaetz, J., Andersson, A. M., Petersen, J. H., Nordkap, L., Bang, A. K., Ekbom, P., Joensen, U. N., Praetorius, L., Lundstrøm, P., Boujida, V. H., Lanske, B., Juul, A., & Jørgensen, N. (2016). Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men. Human Reproduction (Oxford, England), 31(8), 1875-1885. https://doi.org/10.1093/humrep/dew152
  • Boisen, I. M., Bøllehuus Hansen, L., Mortensen, L. J., Lanske, B., Juul, A., & Blomberg Jensen, M. (2017). Possible influence of vitamin D on male reproduction. The Journal of Steroid Biochemistry and Molecular Biology, 173, 215-222. https://doi.org/10.1016/j.jsbmb.2016.09.023
  • Cavallini, G. (2006). Male idiopathic oligoasthenoteratozoospermia. Asian Journal of Andrology, 8(2), 143-157. https://doi.org/10.1111/j.1745-7262.2006.00123.x
  • Ciccone, I. M., Costa, E. M., Pariz, J. R., Teixeira, T. A., Drevet, J. R., Gharagozloo, P., Aitken, R. J., & Hallak, J. (2021). Serum vitamin D content is associated with semen parameters and serum testosterone levels in men. Asian Journal of Andrology, 23(1), 52-58. https://doi.org/10.4103/aja.aja_9_20
  • Cisneros, F. J. (2004). DNA methylation and male infertility. Frontiers in Bioscience: A Journal and Virtual Library, 9, 1189-1200. https://doi.org/10.2741/1332
  • Fackler, M. J., McVeigh, M., Mehrotra, J., Blum, M. A., Lange, J., Lapides, A., Garrett, E., Argani, P., & Sukumar, S. (2004). Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer. Cancer Research, 64(13), 4442-4452. https://doi.org/10.1158/0008-5472.CAN-03-3341
  • Goodrich, R., Johnson, G., & Krawetz, S. A. (2007). The preparation of human spermatozoal RNA for clinical analysis. Archives of Andrology, 53(3), 161-167. https://doi.org/10.1080/01485010701216526
  • Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., Murad, M. H., & Weaver, C. M. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism, 96(7), 1911-1930. https://doi.org/10.1210/jc.2011-0385
  • Hussain, F., Malik, A., Qureshi, M., Imran, M., Waquar, S., Shafique, H., Rana, Z., Thu, H., & Hussain, Z. (2018). Homeostatic relevance of vitamin D in maintaining male fertility in human: down-regulation of oxidative stress and upregulation of anti-oxidative defence and steroidal hormones. Asian Pacific Journal of Reproduction, 7(2), 56-61. https://doi.org/10.4103/2305-0500.228014
  • Kumar, N., & Singh, A. K. (2015). Trends of male factor infertility, an important cause of infertility: A review of literature. Journal of Human Reproductive Sciences, 8(4), 191-196. https://doi.org/10.4103/0974-1208.170370
  • Lerchbaum, E., & Obermayer-Pietsch, B. (2012). Vitamin D and fertility: A systematic review. European Journal of Endocrinology, 166(5), 765-778. https://doi.org/10.1530/EJE-11-0984
  • Li, L. C., & Dahiya, R. (2002). MethPrimer: Designing primers for methylation PCRs. Bioinformatics (Oxford, England), 18(11), 1427-1431. https://doi.org/10.1093/bioinformatics/18.11.1427
  • Ostermeier, G. C., Dix, D. J., Miller, D., Khatri, P., & Krawetz, S. A. (2002). Spermatozoal RNA profiles of normal fertile men. Lancet (London, England), 360(9335), 772-777. https://doi.org/10.1016/S0140-6736(02)09899-9
  • Ramlau-Hansen, C. H., Moeller, U. K., Bonde, J. P., Olsen, J., & Thulstrup, A. M. (2011). Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertility and Sterility, 95(3), 1000-1004. https://doi.org/10.1016/j.fertnstert.2010.11.002
  • Rehman, R., Lalani, S., Baig, M., Nizami, I., Rana, Z., & Gazzaz, Z. J. (2018). Association between vitamin D, reproductive hormones and sperm parameters in infertile male subjects. Frontiers in Endocrinology, 9, 607. https://doi.org/10.3389/fendo.2018.00607
  • Saccone, D., Asani, F., & Bornman, L. (2015). Regulation of the vitamin D receptor gene by environment, genetics and epigenetics. Gene, 561(2), 171-180. https://doi.org/10.1016/j.gene.2015.02.024
  • Vladoiu, S., Botezatu, A., Anton, G., Manda, D., Paun, D. L., Oros, S., Rosca, R., & Dinu Draganescu, D. (2017). The involvement of VDR promoter methylation, CDX-2 VDR polymorphism and vitamin D levels in male infertility. Acta Endocrinologica (Bucharest), 13(3), 294-301. https://doi.org/10.4183/aeb.2017.294
  • World Health Organization (WHO). (2010). WHO laboratory manual for the Examination and processing of human semen. WHO.
  • Yang, B., Sun, H., Wan, Y., Wang, H., Qin, W., Yang, L., Zhao, H., Yuan, J., & Yao, B. (2012). Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men. International Journal of Andrology, 35(6), 783-792. https://doi.org/10.1111/j.1365-2605.2012.01287.x


Created by admin. Last Modification: Friday July 2, 2021 00:59:58 GMT-0000 by admin. (Version 3)
See any problem with this page? Report it (FINALLY WORKS)