VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma’anshan Birth Cohort (MABC) Study
Journal of Diabetes Research, Volume 2019, https://doi.org/10.1155/2019/8313901
Beibei Zhu,1,2 Kun Huang,1,2 Shuangqin Yan,3 Jiahu Hao,1,2 Peng Zhu,1,2 Yao Chen,1,2 Aoxing Ye,1,2 and Fangbiao Tao1,2
1 Department of Maternal, Child & Adolescent Health, Anhui Medical University, Hefei, China
2 Anhui Provincial Key Laboratory of Population Health & Aristogenics, Anhui Medical University, Hefei, China
3 Ma’anshan Maternal and Child Health Care Center, Ma’anshan, China
Correspondence: Fangbiao Tao; taofangbiao at 126.com
Items in categories: Diabetes + Pregnancy + Vitamin D Receptor are listed here:
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
Items in categories: Diabetes + Pregnancy are listed here:
- Gestational Diabetes best fought by Vitamin D plus probiotics – RCT review Dec 2023
- Diabetes 30% more likely in those with low birth weight - June 2023
- Gestational Diabetes Mellitus 10X more-likely if low vitamin D in first trimester – July 2022
- Gestational Diabetes 2.1 X more likely if less than 30 ng of Vitamin D - July 2022
- Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019
- Maternal Diabetes and Risk of Autism in Offspring – JAMA June 2018
- Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018
- Gestational Diabetes 1.9 X more likely if low vitamin D – review Dec 2017
- Congenital Heart Disease is associated with gestational diabetes in first trimester (need Vitamin D and Omega-3 early) Dec 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017
- Low vitamin D plus gestational diabetes resulted in increased ICU use, SGA – Oct 2016
- Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017
- Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Gestational Diabetes 3.7 X more likely if smoke and have low vitamin D (no surprise) – Feb 2016
- Gestational Diabetes helped by Vitamin D and Calcium (also less C-section and LGA) – RCT Jan 2016
- T1 Diabetes in child not prevented by a tiny amount of vitamin D during pregnancy – Nov 2015
- Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015
- Gestational Diabetes increasing, especially in dark skinned women (low vitamin D) - 2007
- Increased Gestational Diabetes and poorer infant health associated with low vitamin D – June 2015
- Gestational Diabetes in 10 percent of pregnancies, vitamin D probably helps – Jan 2014
- Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015
- Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
- Will 1600 IU vitamin D prevent gestational diabetes – no, not enough, July 2013
- Vitamin D protects against many types of health problems – review May 2013
- Dr. Holick video on vitamin D - March 2013
- Gestational diabetes 2.2X more likely below 10 ng of vitamin D – June 2012
- Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012
- Type I diabetes 2X more likely if mother had low vitamin D – Jan 2012
- 300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011
- Less muscle and insulin resistance for children of vitamin D deficient mothers – Jan 2011
- Vitamin D Levels at Birth May Predict Obesity Risk at age 3 - Oct 2010
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Aim. This study investigated the associations among early pregnancy vitamin D concentrations, seasonality, and vitamin D metabolic gene variants and how these variables related alone and in interaction with the risk of gestational diabetes mellitus (GDM).
Methods. Research participants were women from the Ma'anshan birth cohort study in China. The overall study included 3110 women to explore the association between early pregnancy vitamin D concentrations and the risk of GDM. In the current analysis, a nested case-control study of 274 GDM cases and 380 controls was conducted to investigate seven vitamin D metabolic gene variants and the risk of GDM. Vitamin D concentrations were measured by radioimmunoassay. Genotypes were determined by improved multiple ligase detection reaction. Interactions between genetic variants and vitamin D as predictors of the risk of GDM were evaluated by a pair-wise analysis under a multiplicative interaction model.
Results. Vitamin D concentrations were not significantly associated with the risk of GDM (OR = 0.79, 95% CI = 0.55-1.13) after adjusting for seasonality. Fall-winter conceptions had a 37% decreased risk of GDM compared with spring-summer conceptions (OR = 0.63, 95% CI = 0.49-0.81), independent of vitamin D concentrations.
Two VDR gene variants
- rs1544410 (OR = 2.03, 95% CI = 1.17 -3.51 for CT versus CC) and
- rs731236 (OR = 2.42, 95% CI = 1.29-4.55 for GA versus AA)
were significantly associated with the risk of GDM. No interactions among genetic variants and vitamin D concentrations were detected.
Conclusion. Early pregnancy vitamin D insufficiency or deficiency was not significantly associated with the risk of GDM. The results of this study emphasize the importance of genetic variants in VDR and conception season as factors that affect the risk of GDM.