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Vitamin D activation is mainly done by the tissues, not the Liver and Kidneys

Speculation of the full activation of Vitamin D by the tissues has ranged from 50% up to 90%
Many charts of Vitamin D activation only show the liver & Kidney, and ignore activation by tissues


85% activation by Tissues – 2011

New vitamin D analogs and changing therapeutic paradigms
Kidney Int. 2011 Apr;79(7):702-7. doi: 10.1038/ki.2010.387
Cunningham J1, Zehnder D.
Centre for Nephrology, UCL Medical School, Royal Free Campus, London, UK. drjohncunningham at googlemail.com
 Download the PDF from VitaminDWiki
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Vitamin D compounds have been used successfully to treat secondary hyperparathyroidism for almost three decades. Side effects of increased levels of serum calcium and phosphate and potential complications have increasingly been recognized as problematic, and this has become an even more difficult clinical challenge with the desire to capitalize on some of the pleiotropic effects of vitamin D. Nonclassical nuclear vitamin D receptor (VDR) effects on the cardiovascular system, kidneys, and immune system, with the prospect of improved patient survival, have moved to center stage. Selective vitamin D compounds with minimal effects on mineral metabolism and with maximal cardiovascular and renal benefits are now needed. New vitamin D compounds already in clinical use, which have an improved side-effect profile and differential nonclassical effects compared with calcitriol, are limited to the three licensed pharmaceuticals: paricalcitol, 22-oxacalcitriol, and doxercalciferol. Other compounds are under early development and it is anticipated that these novel therapeutic concepts will result in new vitamin D therapies that will help to reduce the high mortality rate patients with kidney disease experience.
74 citations of this study as of July 2023


2 Activation paths have some different genes

Genetics category listing contains the following

328 articles in the Genetics category

see also

Vitamin D blood test misses a lot
in Visio for 2023

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain

See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
13064 85 percent.jpg admin 29 Nov, 2019 42.24 Kb 1019
13063 New vitamin D analogs and changing therapeutic paradigms.pdf admin 29 Nov, 2019 194.43 Kb 553