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COVID-19 5X worse if poor Vitamin D gene (CYP2R1) – June 2021

Front Nutr. 2021 Jun 4;8:689419. doi: 10.3389/fnut.2021.689419. eCollection 2021. DOI: 10.3389/fnut.2021.689419
Nikola Kotur 1, Anita Skakic 1, Kristel Klaassen 1, Vladimir Gasic 1, Branka Zukic 1, Vesna Skodric-Trifunovic 2 3, Mihailo Stjepanovic 2 3, Zorica Zivkovic 4 5, Olivera Ostojic 4, Goran Stevanovic 3 6, Lidija Lavadinovic 6, Sonja Pavlovic 1, Biljana Stankovic 1

Statistically significant portion of table for adults

73 adults in Serbia

  • CYP2R1 gene semi-activates Vitamin D in the body.
  • CYP2R1 gene is in both the liver and tissues
  • CYP2R1 gene is essential to use any form of vitamin D: oral, sun, UV, topical, etc.
  • A poor CYP2R1 gene results in less Vitamin D being available to the body
    • But a poor CYP2R1 can be noticed by a Vitamin D blood test
  • DHCR7 gene contorls how much Sun/UVB gets converted into Vitamin d
  • Many other poor vitamin D genes are not noticed by blood tests

Genetics category has the following

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

Vitamin D pages containing "CYP2R1" in title

Items found: 22
Title Modified
High-fat diet reduces CYP2R1 gene needed to make semi-activated vitamin D (mice) – Aug 2021 28 Aug, 2021
COVID-19 5X worse if poor Vitamin D gene (CYP2R1) – June 2021 21 Jun, 2021
Hypothesis: Obesity reduces Vitamin D production by repressing CYP2R1 gene in liver and fat tissue – July 2020 21 Jul, 2020
Poor CYP2R1 gene results in lower vitamin D and 2X increase in T1 Diabetes – Sept 2019 16 May, 2020
Fasting and Diabetes both reduce Vitamin D activation (CYP2R1 in rodents) – May 2019 19 Nov, 2019
Lung Cancer (NSLC) more lethal if poor Vitamin D gene ( CYP2R1) – Oct 2019 17 Oct, 2019
Poor CYP2R1 gene reduces blood response to Vitamin D supplementation – Aug 2019 20 Jul, 2019
Response to Vitamin D varied by 12 ng due to gene variants (CYP2R1) – Aug 2019 15 Jun, 2019
CYP2R1 (vitamin D 25-hydroxylase ) semiactivates vitamin D in many places in the body 22 Feb, 2019
CYP2R1 gene problem increases Multiple Sclerosis risk by 1.4X – Dec 2018 16 Dec, 2018
Breast Cancer far more likely in the sister having poor Vitamin D binding protein or poor CYP2R1 gene – March 2018 18 Mar, 2018
Multiple Sclerosis 1.4 times more likely if poor CYP2R1 (Vitamin D) gene – Aug 2017 05 Aug, 2017
Vitamin D insufficiency was 3.7 X more likely if CYP2R1 gene variation– June 2014 02 Aug, 2016
CYP2R1 mutations also cause vitamin D-deficient rickets – July 2016 02 Aug, 2016
GC, CYP2R1 and DHCR7 genes associated with low vitamin D levels in China – 2012, 2013 15 Apr, 2016
CYP2R1 and GC variations decrease vitamin D response – PHD thesis Nov 2015 18 Feb, 2016
CYP2R1 gene probably responsible for low vitamin D response – RCT April 2014 02 Jun, 2015
Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D – Oct 2013 24 Feb, 2015
Vitamin D levels reduced about 15 percent in those with CYP2R1 or GC gene variants – Feb 2014 30 Oct, 2014
Genes (CYP2R1 and GC) which restrict the amount of Vitamin D which gets into bloodstream – June 2014 15 Jul, 2014
GC and CYP2R1 genes associated with higher summer vitamin D levels – Jan 2013 04 Mar, 2014
Mice lacking CYP2R1 enzyme activate about half of much vitamin D – Sept 2013 17 Oct, 2013

Vitamin D pages containing "DHCR7" in title

Items found: 5

Items in both categories Virus and Genetics:

Items in both categories Virus and Vitamin D Receptor:

Wonder why this study did not find an association between VDR genes and COVID-19

 Download the PDF from VitaminDWiki

Background: COVID-19 pandemic has proved to be an unrelenting health threat for more than a year now. The emerging amount of data indicates that vitamin D, zinc and selenium could be important for clinical presentation of COVID-19. Here, we investigated association of genetic variants related to the altered level and bioavailability of vitamin D, zinc and selenium with clinical severity of COVID-19.

Methods: We analyzed variants in genes significant for the status of vitamin D (DHCR7/NADSYN1 rs12785878, GC rs2282679, CYP2R1 rs10741657, and VDR rs2228570), zinc (PPCDC rs2120019) and selenium (DMGDH rs17823744) in 120 Serbian adult and pediatric COVID-19 patients using allelic discrimination. Furthermore, we carried out comparative population genetic analysis among European and other worldwide populations to investigate variation in allelic frequencies of selected variants.

Results: Study showed that DHCR7/NADSYN rs12785878 and CYP2R1 rs10741657 variants were associated with severe COVID-19 in adults (p = 0.03, p = 0.017, respectively); carriers of DHCR7/NADSYN TG+GG and CYP2R1 GG genotypes had 0.21 and 5.9 the odds for developing severe disease, OR 0.21 (0.05-0.9) and OR 5.9 (1.4-25.2), respectively.
There were no associations between selected genetic variants and disease severity in pediatric patients. Comparative population genetic analysis revealed that Serbian population had the lowest frequency of CYP2R1 rs10741657 G allele compared to other non-Finish Europeans (0.58 compared to 0.69 and 0.66 in Spanish and Italian population, respectively), suggesting that other populations should also investigate the relationship of CYP2R1 variant and the COVID-19 disease course.

Conclusion: The results of the study indicated that vitamin D related genetic variants were implicated in severe COVID-19 in adults. This could direct prevention strategies based on population specific nutrigenetic profiles.

Vitamin D gene activation varies around the world

Seem that areas with darker skins have genes that are more efficient at converting UVB from sun into Vitamin D

SRB, Serbian;
CEU, Utah residents with Northern and Western European ancestry (1KGP);
GBR, British in England and Scotland (1KGP);
TSI, Tuscany in Italy (1KGP);
IBS, Iberian populations in Spain (1KGP);
FIN-Finnish European (gnomAD);
NFE-non-Finnish European, including Northwestern European, Bulgarian,
    Estonian, Swedish, Southern European, and Other non-Finnish European (gnomAD);
AFR, African (gnomAD);
EA, East Asian (gnomAD);
SA, South Asian (gnomAD);
LAT, Latino/Admixed American (gnomAD);
ASJ, Ashkenazi Jewish (gnomAD).

Created by admin. Last Modification: Tuesday July 20, 2021 14:39:39 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
15773 Serbia Map.jpg admin 21 Jun, 2021 15:03 33.82 Kb 236
15772 VDR.jpg admin 21 Jun, 2021 14:12 33.43 Kb 225
15771 DHCR7.jpg admin 21 Jun, 2021 14:11 36.65 Kb 229
15770 Genes and COVID.jpg admin 21 Jun, 2021 14:10 41.36 Kb 293
15769 COVID and Vitamin D genes.pdf PDF 2021 admin 21 Jun, 2021 14:10 604.37 Kb 151
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