Loading...
 
Translate Register Log In Login with facebookLogin and Register

Genes may account for some of AA Breast Cancer – April 2012

Variants in the vitamin D pathway, serum levels of vitamin D,

and estrogen receptor negative breast cancer among African-American women: a case-control study

Song Yao, Gary Zirpoli, Dana H Bovbjerg, Lina Jandorf, Chi-Chen Hong, Hua Zhao, Lara E Sucheston, Li Tang, Michelle Roberts, Gregory Ciupak, Warren Davis, Helena Hwang, Candace S Johnson, Donald L Trump, Susan E McCann, Foluso Ademuyiwa, Karen S Pawlish, Elisa V Bandera and Christine B Ambrosone
Breast Cancer Research 2012, 14:R58 doi:10.1186/bcr3162, Published: 5 April 2012

Introduction
American women of African ancestry (AA) are more likely than European Americans (EA) to have estrogen receptor (ER)-negative breast cancer. 25-hydroxyvitamin D (25OHD) is low in AAs, and was associated with ER-negative tumors in EAs. We hypothesized that racial differences in 25OHD levels, as well as in inherited genetic variations, may contribute, in part, to the differences in tumor characteristics.

Methods
In a case (n=928)-control (n=843) study of breast cancer in AA and EA women, we measured serum 25OHD levels in controls and tested associations between risk and tag single nucleotide polymorphisms (SNPs) in VDR, CYP24A1 and CYP27B1, particularly by ER status.

Results
More AAs had severe vitamin D deficiency (<10 ng/ml) than EAs (34.3% vs 5.9%), with lowest levels among those with the highest African ancestry.
Associations for SNPs differed by race.
Among AAs, VDR SNP rs2239186, associated with higher serum levels of 25OHD, decreased risk after correction for multiple testing (OR=0.53, 95% CI=0.31-0.79, p by permutation=0.03), but had no effect in Eas.
The majority of associations were for ER-negative breast cancer, with seven differential associations between AA and EA women for CYP24A1 (p for interaction <0.10).
SNP rs27622941 was associated with a >twofold increased risk of ER-negative breast cancer among AAs (OR=2.62, 95% CI=1.38-4.98), but had no effect in EAs. rs2209314 decreased risk among EAs (OR=0.38, 95% CI=0.20-0.73), with no associations in Aas.
The increased risk of ER-negative breast cancer in AAs compared to EAs was reduced and became non-significant (OR=1.20, 95% CI=0.80-1.79) after adjusting for these two CYP24A1 SNPs.

Conclusions
These data suggest that genetic variants in the vitamin D pathway may be related to the higher prevalence of ER-negative breast cancer in AA women.


PDF is attached at the bottom of this page

See also VitaminDWiki


Attached files

ID Name Comment Uploaded Size Downloads
1216 Breast Cancer AA.pdf PDF admin 06 Apr, 2012 11:58 608.14 Kb 864
See any problem with this page? Report it (FINALLY WORKS)