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2260 diseases found to be fought by fully-activated Vitamin D (Calcitriol) – July 2024

Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization

Front Cardiovasc Med. 2024 Jun 25:11:1388025. doi: 10.3389/fcvm.2024.1388025
Anton Fliri 1, Shama Kajiji 1 founders of Emergent System Analytics

  • "Unlocking the power of proteomics, emergent illuminates a personalized path to health, where precision meets potential, and every individual's unique biology becomes the cornerstone of their well-being."


A small portion of the proteins affected by Calcitriol
Image
Among the leading causes of natural death are cardiovascular diseases, cancer, and respiratory diseases. Factors causing illness include genetic predisposition, aging, stress, chronic inflammation, environmental factors, declining autophagy, and endocrine abnormalities including insufficient vitamin D levels. Inconclusive clinical outcomes of vitamin D supplements in cardiovascular diseases demonstrate the need to identify cause-effect relationships without bias. We employed a spectral clustering methodology capable of analyzing large diverse datasets for examining the role of vitamin D's genomic and non-genomic signaling in disease in this study. The results of this investigation showed the following:

  • (1) vitamin D regulates multiple reciprocal feedback loops including p53, macrophage autophagy, nitric oxide, and redox-signaling;
  • (2) these regulatory schemes are involved in over 2,000 diseases.

Furthermore, the balance between genomic and non-genomic signaling by vitamin D affects autophagy regulation of macrophage polarization in tissue homeostasis. These findings provide a deeper understanding of how interactions between genomic and non-genomic signaling affect vitamin D pharmacology and offer opportunities for increasing the efficacy of vitamin D-centered treatment of cardiovascular disease and healthy lifespans.
 Download the PDF from VitaminDWiki

Additional diseases are probably fought by local (non-liver) generation of Calcitriol

Vitamin D affects 1289+ Genes, but even more proteins (in current study)

344 articles in the Genetics category

see also

Vitamin D blood test misses a lot
in Visio for 2023

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
        especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
    3) DNA and VDR tests - 100 to 200 dollars $100 to $250
    4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
       Genes are good, have enough Magnesium, etc.
    5) Back Pain
       probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
      • The founder of VitaminDWiki took action with clues #3&5
212+ references in the study
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21414 D, CVD, macrophage polarization_CompressPdf.pdf admin 10 Jul, 2024 594.14 Kb 93