Genes evolve to adapt to excess or low vitamin D (Eskimo, Reindeer, etc.) – June 2019

Note: It probably takes many 1,000's of years for the genes to adapt

• Eskimos evolved to get and limit Vitamin D from food
• Inuit and vitamin D

Reindeer genes are 20X better at activating Vitamin D than other mammals

Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus) - June 2019
 Download the PDF fromSci-Hub via VitaminDWiki

POR = P450 Oxidoreductase

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Suspect also that Reindeer have gene modifications which increase the Vitamin D half life from ~2 months to > 5 months

Genetics category listing contains the following

318 articles in the Genetics category

see also

• Vitamin D Receptor has 480 items
• Vitamin D Binding Protein = GC has 170 items
• CYP27B1 has 56 items
• CYP24A1 in title of 34+ items
• CYP24R1 25+ items
• Calcidiol has 45 items
• Calcitriol has 56 items
• Topical Vitamin D
• Nanoemulsion Vitamin D may be a substantially better form
• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
• CYP3A4 (7 as of Dec 2022)
• Getting Vitamin D into your body

Vitamin D blood test misses a lot

• Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
• Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
• A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
•    Commercially available 2019
  • However, test results would vary in each tissue due to multiple genes
• Good clues that Vitamin D is being restricted from getting to the cells
  1) A vitamin D-related health problem runs in the family
  • especially if it is one of 51+ diseases related to Vitamin D Receptor
  
  2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
  3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
  • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
  
  4) Back Pain
  • probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
    • The founder of VitaminDWiki took action with clues #3&4