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Toggle Health Problems and D

Overview of VitaminDWiki

Although researchers, physicians, and clinical nutritionists can't agree completely on dose rates, recommended blood levels, and expected clinical outcomes, there is no question that vitamin D status plays an important role in reducing, preventing, and in some cases, treating a wide range of chronic degenerative medical conditions. The purpose of the VitaminDWiki is to provide a convenient, comprehensive, and authoritative resource to investigate how optimizing vitamin D status may be helpful for you or someone you care about. It's a big subject so we urge you to spend some time exploring and learning about this important nutrient.

Updated 2017


Table of contents

Vitamin D is associated with many health problems

Less sun ==> Less Vitamin D ==> Less Health (chart)

Less Sun Less D Less Health
click on image for details and translation
70 Proofs that Vitamin D prevents or treats the following diseases
ADHD,  Alcoholic Liver Cirrhosis,  ALS,  Alzheimer's,  Antibiotic Use in Seniors,  Asthma,  Autism,  Autoimmune Diseases,   Back pain,  Blood Cell Cancer,   Breast Cancer,   Cardiovascular,  Cholesterol,  Chronic Hives,  Chronic Kidney Disease,  Cluster Headaches,  Congestive Heart Failure (Infants),  COPD,  Crohn's Disease,  C-Section and Pregnancy Risks,  Cystic Fibrosis,  Depression,   Diabetes,  Diabetic Neuropathy,  Eczema,   Falls,  Fatigue,  Fatty Liver (Child),  Fibromyalgia,  Gestational Diabetes,  Gingivitis,  Growing Pains,  Hay Fever,  Heart Attack,  Hemodialysis,  Hepatitis-C,   Hip Fractures,  Hypertension,  Influenza,  Irritable Bowel Syndrome,  Ischemic Stroke,  Knee Osteoarthritis,  Leg Ulcers,   Low Birth Weight,  Lupus,  Male Infertility,   Menstrual Pain,  Metabolic Syndrome,  Middle Ear Infection (Infants),  Mite Allergy,  Multiple Sclerosis,  Non-Alcoholic Fatty Liver Disease,  Osteoarthritis,  Parkinson's Disease,  Perinatal Depression,  Pneumonia (Ventilator-associated),  Poor Sleep,  PreDiabetes,  Preeclampsia,  Pre-term Birth,  Prostate Cancer,  Quality of Life,   Raynaud's Pain,   Respiratory Tract Infection,  Restless Leg Syndrome,   Rheumatoid Arthritis,   Rickets,  Sarcopenia,  Sepsis,  Short Neonates,  Sickle Cell,  Stronger Senior Muscles,  Survive ICU,  TB,  Trauma Death,  Traumatic Brain Injury,  Tuberculosis,  Ulcerative Colitis,  Urinary Tract Infection,  Vaginosis,  Vertigo,  Warts,  Weight Loss

Select pink box in the upper right to select a language
Click on underlined items for details

Health Problem Treat
Prevent
Reduction by Vit DRCT = Randomized Controlled Trial
   * = link to additional RCT
CT = Clinical Trial
HypertensionT
P
149 to 142 mm Hg
HT risk reduced 10X
RCT*  *, 2400 IU.  100,000 IU*
When Vitamin D > 40 ng
Cardiovascular after attack T 32 % fewer deaths CT 1000 IU
Diabetes Type 1 P 85 % 12,000 kids, 2000 IU
Diabetes Type 2T 62 % RCT* CRP reduction, 4000 IU
Injection is far better - RCT *
RCT 50,000 IU/2weeks + probiotics
RCT 5,000 IU daily 6 months
Back Pain T 95 %
reduced 50%
5000/10000 IU
60,000 IU weekly
Influenza P 90 % RCT *, 2000 IU
Falls P 50%RCT, 100,000 IU monthly
RCT with Meals on Wheels 2016
Hip Fractures P 30 % RCT * 800 IU
Rickets P 98 % Turkey, 400 IU
NOT RCT, given to all children
Raynaud's Syndrome T 40 % RCT, visual scale, 20000 IU Avg
Menstrual pain P 76 % RCT, 7000 IU Avg,
70% reduction 2018
PMS reduced by half
Pregnancy risks P 50 % RCT, 4000 IU
C-section, unplanned P 50 % RCT, 4000 IU, small study
Low birth weight P 60 % RCT * 1000 IU of D2
TBP 60 % RCT, 800 IU
Breast Cancer P 60 % RCT, 1100 IU (2007)
Rheumatoid Arthritis pain T 40 % RCT, 500 IU, added to prescription
Cystic Fibrosis T 75 %
2nd study improved
RCT, pilot 4X fewer deaths 250,000 IU
RCT, pilot 8,200 IU
Chronic Kidney T 90 to 70 PTH RCT, 3500 IU,
Respiratory Tract Infection P 63 % 3 RCT, 4000 IU 1 year 2nd 2000/800 IU
20,000 IU weekly
Lupus T
T
zero flares
Pain reduced
Loading then 100,000 IU monthly,
RCT too
RCT 4,000 IU
Sickle Cell T Less pain
RCT, up to 100,000 IU/week
Leg ulcer healing T 4X faster RCT, 50,0000 IU/week, small study
Traumatic Brain Injury T 2X RCT, 20,0000 IU/day with progesterone
Parkinson's DiseaseT StabilizedRCT, 1200 IU/day
Multiple SclerosisP
T
68%
95% were CURED
RCT, 7100 IU prevent pre-MS ==> MS
20,000 to 140,000 IU/day
Congestive Heart Failure T 90 % RCT, 1000 IU infants (also: Adults, not RCT)
Middle Ear Infection P 30 % RCT, 1000 IU infants
GingivitisT 88 %RCT, 2000 IU
Muscle in seniors T 17 % more muscle RCT, 4000 IU
Antibiotic use when >70y T 47 % RCT, 60,000 IU monthly
Infants tallerBenefit1 cm tall RCT, 50,000 IU weekly,
for 8 weeks while pregnant
Gestational Diabetes T Reduced 3X RCT, 2 doses of 50,000 IU
After Heart Attack T +6% ejection fraction RCT, 800,000 IU one time
Prostate Cancer T Fewer +cores RCT, 4000 IU (2012)
Asthma P   T Reduced symptoms RCT, 60K IU/month;
RCT 50K IU/week
Need good D at 4 weeks into preg.
Depression T Reduced RCT 300,000 IU injection
RCT 1500 IU helped Prozac
RCT 50,000 IU weekly, elderly
Low vitamin D
while breastfed
P All infants > 20 mg RCT, 5,000 IU
Fibromyalgia T Half of many still has FibroRCT, 30-48 ng
RCT 50K IU/week
Hives, Chronic T Reduced 40% RCT, 4000 IU added
CholesterolT Reduced 4 mg RCT, 400 IU + Ca
Weight Loss T lost 5 more lbs RCT, 2000 IU +diet +exercise
Gestational DiabetesP 40% RCT * , 5,000 IU
Chronic Obstructive
Pulmonary Disease
T 17X improvement CT, 50,000 IU weekly
RCT 100,000 IU monthly
Asthma T 1/2 Asthma attacks RCT >42 mg of vitamin D
Quality of Life (QoL) T Nursing Home QoL CT, 4,000 IU in daily bread
Death of Critically Ill
Patients
T 20% increase in survivability RCT 540 K IU loading than 90K monthly
Restless Leg Syndrome T Score 26 ==> 10 CT, Vitamin D dose size
not stated in abstract
Hepatitis-C T Aided normal drugs RCT 2.000 IU
Crohn's disease T improved when > 30 ng
2nd study fewer relapses
RCT 2,000 IU
10,000 IU RCT
Pre-term birth P 2.5X decrease, also: fewer
c-section & better Apgar
RCT 2,000 IU India
Cluster headaches T CH eliminated in 60% 10,000 IU, Mg, Omega-3, etc
Autism T 80% improved CT 300 IU/kg/day for 3 months
PreDiabetes T ~20% reduced RCT 60,000 IU/month
Weight loss:
Overweight and Obese
T 12 lbs in 6 months RCT 100,000 IU/month
Sarcopenia = muscle loss T 27% increase RCT 1,000 IU
Growing Pains T 60% decrease ~100,000 IU/month -NOT RCT
2nd study, similar results
Osteoarthritis pain T 60% decrease 50,000 IU/weekly - NOT RCT
ALS T helped 2,000 IU - NOT RCT, given to all
Vertigo T 3X reduction if raised > 10ng 600,000 IU load, then maint.
NOT RCT, given to all
Warts T 80% eliminated injection NOT RCT
60,000 IU/injection
Metabolic Syndrome P reduced 44% when VitD
increased by 30 ng
NOT RCT, given to all
Hay fever P reduced 48% RCT   1,000 IU for 30 days
Preeclampsia P Recurrance cut in half
3 RCT 3.6 X less likely if > 30 ng
50,000 IU every 2 weeks
4,000 IU daily
Blood cell cancer
Multiple Myeloma
T Survival 90% vs 50%10,000 IU/week
NOT RCT, given to all
Irritable Bowel Syndrome T Reduced3,000 IU spray RCT
Urinary Tract Infection P 50% reduction RCT 20,000 IU weekly
Mite Allergy P 5X reductionRCT 2,000 IU preg, 800 IU child
Perinatal depression
(depression near birth)
T 50% reduction RCT 2,000 IU for just a few weeks
Vaginosis T 10X reductionRCT 2,000 IU
Eczema T Reduced2 RCT 1,600 IU
Non-Alcoholic
Fatty Liver Disease
T Reduced RCT 20,000 IU weekly
Knee Osteoartiritis T Pain Reduced RCT 60,000 IU monthly after loading dose
Tuberculosis T Faster Recovery RCT single 450,000 IU dose
Stroke - Ischemic T Faster Recovery RCT single 600,000 IU injection
RCT single 300,000 IU injection
Sepsis T Reduce ICU and Hospital
length of stay by 7 days each
RCT 400,000 IU
Trauma deaths T 50% fewer deaths Vitamin D & Glutamine
NOT RCT, given to all
Hemodialysis patients T helped 50,000 IU weekly NOT RCT, given to all
Fatty liver - child T 2 X reduction RCT  Vitamin D & DHA
Fatigue T Reduced 100,000 IU single dose
NOT RCT, given to all
Sleep Disorders T Nicely treated RCT  50.000 IU bi-weekly
Pneumonia
(Ventilator-associated)
T RCT   Death rate cut in half300,000 IU injection
Infertile males T birth rate doubled RCT   300,000 IU + maint
Waist size T Waist size reduced 3 cm 100,000 IU loading + maint for 6 months
for those with Metabolic Syndrome
NOT RCT, given to all
Attention Deficient
Hyperactivity Disorder
T Reduced
Reduced
RCT  3,000 IU for 12 weeks
RCT  50,000 IU weekly
Alcoholic liver cirrhosis T improved survival1,000 IU of vitamin D NOT RCT
Diabetic nephropathy T Reduced HOMA-IR, FRS RCT 50,000 IU weekly
Ulcerative Colitis T Reduced 60% RCT 50,000 IU nano daily for a week
Obese weight loss T Lost 3X more pounds $10 of Vitamin D added to
  calorie restriction & walking
Endometriosis T Nicely treated RCT  50.000 IU bi-weekly
Diabetic Wounds T 4X more likely to heal RCT  6,400 daily
Alzheimer's T Often reverseEach person gets a different amount of
Vit D, Omega-3, B12, Iron, etc
Autoimmune P Decrease 30% RCT  Vit D + Omega-3
Smoking T reduce problems RCT  50,000 bi-weekly



Most proofs are RCT (Randomized Controlled Trials), where not even the doctor knows who gets it vitamin D

  • 2 are meta-analysis of multiple RCTs
  • Vitamin D was given to ALL infants in the entire country (Rickets) - not an RCT
  • In several studies researchers felt that it was unethical to not give vitamin D to everyone
  • In some studies the dose size varied with the needs of the person (overweight, etc)
  • In some studies the COFACTORS were adjusted with the needs of the patient%
    • Curing requires the dose size and cofactors to be adjusted to the needs of each patient.


Many Clinical Trials have not found a benefit because of one or more of the following failures:

  1. Fails to use a large enough dose of vitamin D (often < 1,100 IU)
    The Even larger dose needed if: 1) obese, 2) poor gut, 3) sick (many diseases consume lots of vitamin D)
  2. Fails to have given vitamin D for a long enough time (a few RCT lasted less than 5 weeks)
  3. Fails to have given Vitamin D frequently enough. At least every 2 months for D3) - and at least weekly for D2
    Note: Infrequent dosing also causes unbalancing of the body's chemistry
  4. Fails to provide a loading dose, or had too short a duration to restore the vitamin D levels
  5. Fails to use D3 form, instead uses the less effective D2 form
  6. Fails to have a healthy range of Calcium or other important cofactors (especially for bone-related trials
    Also, differences in Magnesium can result in 30% change in response to vitamin D
    Magnesium is dependent on water, food, supplements
  7. Fails to notice the pre-existing vitamin D levels - only those who are low will likely show a benefit
  8. Fails to notice how/when the vitamin D was taken (which can change the response by as much as 2X)
  9. Fails to report on compliance (in one case 40% of the participants did not take the supplements consistently)

Many Meta-Analyses also do not find a benefit because one or more of the above failures
In addition, many meta-analysis average together ALL of the trials
Imagine a story about a meta-analysis of aspirin (which has never been done)
   There would be scores of RCT for aspirin not working with 3 mg doses
   There would be a many RCT of aspirin not working with 30 mg doses
   There would be a few studies of aspirin WORKING with 300+ mg doses
   There would be many studies of small amounts of Willow bark (Vitamin D2 instead of Vitamin D3)
   Then there would be a meta-analysis of aspirin and Willow Bark
   - That meta-analysis would conclude that aspirin and Willow bark do not work.

While about 200 RCTs will be published during 2014, I anticipate only adding 50 to the proofs table due to the reasons listed above
   Also, some trials will not get started due to lack of people willing to go for years with < 500 IU of vitamin D


See also VitaminDWiki: Random Controlled Trials with vitamin D  intervention

More intervention trials for Vitamin D than for the TOTAL of Vitamins A + C + K combined

Vitamin D = 2199, Others = 1803 Vitamin A 702 + Vitamin C 768 + Vitamin K 333    as of Aug 2020

See also VitaminDWiki


Less Sun Less D Less Health
CLICK ON chart for more information and translation

Vitamin D is especially needed during pregnancy

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial


Also, The Vitamin D Receptor limits the amount of Vitamin D in the blood actually gets to the tissue

The risk of 45 diseases at least double with poor Vitamin D Receptor as of Nov 2022


6 times to 55 times more likely to get these health problems

CLICK HERE for entire 3X to 55X list for more information


Health problem - examples


Alzheimers-Cognition

Overview Alzheimer's-Cognition and Vitamin D has the following summary


Breast Cancer

Overview Breast Cancer and Vitamin D contains the following summary and sections


Breathing

Breathing category starts with the following

428 items in Breathing category

Breathing-related Overviews at VitaminDWiki:
Allergy   Lung Cancer   TB   Asthma  Influenza  Colds and flu
Pneumonia   Respiratory infections   COPD   Air Polution   Smoking   Cystic Fibrosis


Cardiovascular

Cardiovascular category listing has 470 items along with related searches 470 items In Cardiovascular category

Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022


Cholesterol, Statins


Diabetes

Overview Diabetes and vitamin D appears to be due to a lack of Vitamin D

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 514 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
    • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

  • Dark Skin 24;   Intervention 55;   Meta-analysis 36;   Obesity 32;  Pregnancy 42;   T1 (child) 38;  Omega-3 11;  Vitamin D Receptor 22;  Genetics 12;  Magnesium 25    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes

Pre-Diabetes

Magnesium


Falls and Fractures

Falls and Fractures category contains the following summary

Falls

Fracture

Click here for details


Kidney

Overview Kidney and vitamin D contains the following summary


Obesity

Overview Obesity and Vitamin D contains the following summary


Osteoporosis

Overview Osteoporosis and vitamin D contains the following summary

  • FACT: Bones need Calcium (this has been known for a very long time)
  • FACT: Vitamin D improves Calcium bioavailability (3X ?)
  • FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
  • FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
  • FACT: Vitamin D supplements are very low cost
  • FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
  • FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
  • FACT: Co-factors help build bones.
  • FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
  • It appears that to TREAT Osteoporosis:
  •        Calcium OR vitamin D is ok
  •        Calcium + vitamin D is good
  •        Calcium + vitamin D + other co-factors is great
  •        Low-cost Vitamin D Receptor activators sometimes may be helpful
  • CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
  • Category Osteoporosis has 202 items
  • Category Bone Health has 295 items

Note: Osteoporosis causes bones to become fragile and prone to fracture
  Osteoarthritis is a disease where damage occurs to the joints at the end of the bones
Osteoporosis category includes the following


Pain

Pain - chronic category has the following

149 items in category Chronic pain

See also


Parkinson’s

Overview Parkinson's and Vitamin D contains the following summary


Schizophrenia

Overview Schizophrenia and Vitamin D contains the following summary
Many reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
13) Schizophrenia risk is decreased if give Vitamin D after birth
14) Schizophrenia symptoms reduced when Vitamin D levels are restored


Sports

Overview Sports and vitamin D has the following summary
Athletes are helped by vitamin D by:

  1. Faster reaction time
  2. Far fewer colds/flus during the winter
  3. Less sore/tired after a workout
  4. Fewer micro-cracks and broken bones
  5. Bones which do break heal much more quickly
  6. Increased VO2 and exercise endurance Feb 2011
  7. Indoor athletes especially need vitamin D
  8. Professional indoor athletes are starting to take vitamin D and/or use UV beds
  9. Olympic athletes have used UV/vitamin D since the 1930's
  10. The biggest gain from the use of vitamin D is by those who exercise less than 2 hours per day.
  11. Reduced muscle fatigue with 10,000 IU vitamin D daily
  12. Muscle strength improved when vitamin D added: 3 Meta-analysis
  13. Reduced Concussions
    See also: Sports and Vitamin D category 262 items

Groups typically needing more Vitamin D


Seniors need more vitamin D - 10 reasons

  1. Senior skin produces 3X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptors as they age
  3. Seniors are indoors more than than when they were younger
    • not as agile, weaker muscles; frail, no longer enjoy hot temperatures
    • (if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
  4. Seniors wear more clothing outdoors than when younger
    • Seniors also are told to fear skin cancer/wrinkles
  5. Seniors often take various drugs which reduce vitamin D
  6. Seniors often have one or more diseases which consume vitamin D
  7. Seniors generally put on weight at they age - and a heavier body requires more vitamin D
  8. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  9. Reduced stomach acid ==>less Magnesium needed to utilize vitamin D
    (would not show up on vitamin D test)
  10. Seniors with poorly functioning kidneys do not process vitamin D as well
    (would not show up on vitamin D test) 2009 full text online  Also PDF 2009
  11. Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)

 Infants-Child

Infant-Child category starts with

Having a good level of vitamin D cuts in half the amount of:

Need even more IUs of vitamin D to get a good level if;

  • Have little vitamin D: premie, twin, mother did not get much sun access
  • Get little vitamin D: dark skin, little access to sun
  • Vitamin D is consumed faster than normal due to sickness
  • Older (need at least 100 IU/kilogram, far more if obese)
  • Not get any vitamin D from formula (breast fed) or (fortified) milk
    Note – formula does not even provide 400 IU of vitamin D daily

Infants-Children need Vitamin D


Pregnant

Overview Pregnancy and vitamin D
Pregnancy category starts with

836 items in Pregnancy category

 - see also

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial
CLICK HERE to see entire page


Darker Skin


Other High Risk Groups

High Risk of little Vitamin D category listing has 62 items and has:

Vitamin D supplementation

Amount of vitamin D needed vs:

More vitamin D needed -nutshell category has the following

Image
Age
Image
Latitude
Image
Season
Image
Obesity
Image
Skin color
Image
Avoid Sun

Supplementation from Zika book (July 20, 2016)

Vitamin D Recommendations: based on hundreds of successful Vitamin D studies (with/without pregnancy)

  • 4,000 IU daily average minimum amount of Vitamin D
    Similar dosing is 50,000 IU bi-weekly (Daily is probably slightly better)
    It is 1/3 the cost and easier to remember than daily dosing.
    Note: Taking vitamin D also increases chance of pregnancy
  • More is needed if likely to have very low levels of vitamin D:
    6,000 IU daily average if:
    • having twins or had a recent birth,
    • health problems associated with low vitamin D
    • indoors a lot or avoid the sun
    • dark skin

    10,000 IU (50,000 IU every 5th day) if:
    • Obese

Image

  • Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 obesity study

    • if diseases run in the family
  • May want to restore levels as quickly as possible with 350,000 IU loading dose
    during pregnancy, especially if there is the threat of Zika
    this gets a strong immune system quickly, not with months of delay using a daily maintenance dose
    • 50,000 IU daily for 1 week if not pregnant
    • 50,000 IU every second day for 2 weeks if pregnant
  • Start ASAP during pregnancy (even before) so as to both avoid Zika and have healthy pregnancy and infant
  • Should use a vitamin D which has no known adverse affects
    No additives, no oils (30% of oil-based Vit D which restrict vitamin D adsorption)
  • Most people (80%?) can take regular vitamin D capsules
    Options if:
    • Not want to take pills – use liquid Vitamin D or pour vitamin D powder from capsule into food/drink
    • Poor gut – several “gut friend” forms are available
    • Vegan – several forms of Vitamin D3 are made from plants such as lichen
    • Halal, Kosher, etc.
  • Magnesium Cofactor 100+ miligrams of element daily – tell why especially during pregnancy
    • Increases the benefits of vitamin D
    • Decreases chance of allergic-type reaction to Vitamin D (from ~ 3 in 1000 to 1 in 1000)
  • Omega-3 Cofactor
  • Vitamin K2 cofactor
  • Test for Vitamin D is nice but very expensive ($60) and not really essential
  • Take vitamin D just after evening meal
    • about~30% more benefit with evening meal, but most anytime is OK
  • Just concerned about average vitamin D during a 2 week time period
    4,000 IU taken daily is virtually identical to 50,000 IU once every two weeks
    OK to have missed your dose for a few days - just take nissed once all at once.

How often should I take 50,000 IU

How often should I take 50000 IU (1.25 mg) of vitamin D


10 minutes of sun not enough

No – 10 minutes per day of sun-UVB is NOT enough

  • 5-10 minutes provides only 1,000 IU ONLY IF you are near the equator
  • AND young
  •  AND not obese
  •   AND have light skin
  •    AND it is summer
  •     AND it is the middle of the day
  •      AND you have lots of skin exposed to the sun
  •       AND you are lying down
  •        AND you are not wearing sunscreen
  •         AND you have a healthy Liver
  •          AND no clouds and nor air pollution
  •           AND you have good response to sunshine (4X variation between individuals)

Loading Dose - to get the benefit as soon as possible

Overview Loading of vitamin D contains the following

Loading dose: 190 studies at VitaminDWiki

Vitamin D loading dose (stoss therapy) proven to improve health overview
If a person is or is suspected to be, very vitamin D deficient a loading dose should be given

  • Loading = restore = quick replacement by 1 or more doses
  • Loading doses range in total size from 100,000 IU to 1,000,000 IU of Vitamin D3
    • = 2.5 to 25 milligrams
  • The size of the loading dose is a function of body weight - see below
    • Unfortunately, some doctors persist in using Vitamin D2 instead of D3
  • Loading may be done as quickly as a single day (Stoss), to as slowly as 3 months.
    • It appears that spreading the loading dose over 4+ days is slightly better if speed is not essential
  • Loading is typically oral, but can be Injection (I.M,) and Topical
  • Loading dose is ~3X faster if done topically or swished inside of the mouth
    • Skips the slow process of stomach and intestine, and might even skip liver and Kidney as well
  • The loading dose persists in the body for 1 - 3 months
    • The loading dose should be followed up with on-going maintenance dosing
    • Unfortunately, many doctors fail to follow-up with the maintenance dosing.
  • About 1 in 300 people have some form of a mild allergic reaction to vitamin D supplements, including loading doses
    • it appears prudent to test with a small amount of vitamin D before giving a loading dose
    • The causes of a mild allergic reaction appear to be: (in order of occurrence)
    • 1) lack of magnesium - which can be easily added
    • 2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
    • 3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )
    • 4) allergy of the gut to Vitamin D - alternative = topical

Toxicity is rare

Overview Toxicity of vitamin D
Graph of dose vs week


Free Vitamin D evaluation service

Free Vitamin D evaluation service had the following questions
Positive answers indicates a possible vitamin D deficiency

  • At night, I ...... have a cold feeling ... have legs that hurt ... have a restless sleep ... wake up suddenly
  • During the day, I am...... listless ... tired ... lethargic ... uninspired
  • I feel cramps or twitches...... in the leg ... in the arm ... in the hand ... in the eyelid
  • I get dizzy...... when I stand up ... when I exert an effort ... around noon ... when that happens, I need to lie down
  • I feel sick...... when I stand up ... when I exert an effort ... around noon ... when that happens, I need to lie down
  • My head hurts or I feel pressure in my head...... when I stand up ... when I exert an effort ... around noon ... when that happens, I need to lie down
  • If I stand or work for an extended period of time, it hurts...... in my neck ... in my lower back ... in the groin ... in the feet
  • The Sun at noon causes...... circulatory problems ... headaches ... an itching skin ... red spots
  • I repeatedly have...... cold hands ... cold feet ... cold legs ... white fingertips
  • My fingernails have…   number of white spots

Cofactors are important if you take a lot of vitamin D for a long time

Vitamin D Cofactors in a nutshell
!!!!Cofactors need to be adjusted when taking a lot of vitamin D for more than a month
"A lot" is more than 4,000 IU Vitamin D daily (average)
There is virtually no agreement as how much of each cofactor is needed vs vitamin D level
The first three cofactors have, like vitamin D, greatly decreased in the human diet in the past 50 years
The goal is to restore Vitamin D, Magnesium, Omega-3, and Vitamin K back to where they had been
   in a nutshell = summed up = condensed

Supplements categories in VitaminDWiki include

Supplement  # of
studies
Increase D
to tissue
Omega-3 374
Many benefits30%?
Magnesium 324
Many need Mg30%
Calcium 213
Reduce
Vitamin K 141
Hard bones,
soft arteries
Iron 64
Vitamin B12 51
Zinc 79
?%
Boron 30
+20%
Iodine 28
Resveratrol 44
>100% if
poor VDR
Curcumin 12
? ?% if
poor VDR
Vitamin C 49

Magnesium

  • About 1 in 300 people have a poor reaction to increasing Vitamin D
       but the Vitamin D reaction (muscle pain) is almost always due to lack of Magnesium
  • Magnesium increases the benefits of vitamin D by about 30% (Mg and Vit. D are synergistic)
  • Magnesium provides a great many health benefits independent of Vitamin D
    • Magnesium is used at 8 stages of Vitamin D metabolism
  • 100 milligrams of Magnesium (say from Magnesium Chloride) seems to be enough, even with high levels of vitamin D
    Some people (not a consensus) believe that only 100 mg of Mg can be taken up by the gut at a time
    If possible, take your Magnesium several times during the day - not just once
    • Vitamin D appears to consume Magnesium
    • People with > 100 ng of Vitamin D (and do not supplement with Mg) are 2.5X more likely to have A-fib
    • Constipation due to low Magnesium after greatly increasing Vitamin D level (personal experience of founder of VitaminDWiki)
  • Overview Magnesium     Magnesium category has 324 items

Omega-3

  • Omega-3 increases active vitamin D - especially in people with poorly functioning livers or kidneys
  • 1 gram of Omega-3 seems to be enough. Note: different brands have widely different bio-availability
  • Overview Omega-3     Omega-3 category has 374 items

Vitamin K2

  • K2 Keeps Calcium in bones and out of arteries
  • Calcification due to K2 deficiency may be a reason for increased mortality for some diseases for high vitamin D
  • Probably need 100 micrograms per 2,000 IU of vitamin D (i.e. 500 micrograms for 10,000 IU of Vit D)
    • Perhaps Vitamin D consumes Vitamin K, so need more of it
  • Vitamin D decreases the uptake of Vitamin K1 by 50%
    • Perhaps should not take K2 concurrently with Vitamin D.
  • Overview Vitamin K2     Vitamin K category has 141 items

Calcium

  • Too much Calcium is associated with cardiovascular problems years later, not stronger bones
  • Should have less than 750 milligrams of Calcium supplementation
  • Drinking a lot of water helps flush any excess Calcium from the Kidneys
  • Overview Calcium     Calcium category has 213 items

Boron - good, but not as essential

  • Boron increases Vitamin D and Magnesium in the body by ~ 20%
  • Most people Boron deficient now that commercial fertilizers are used
  • Should have 3-10 milligrams of Boron element daily
  • Boron can be extremely low cost, less than $0.01 a day
  • Boron category has 30 items

Zinc - good, but not as essential

  • Extra Zinc does not appear to increase D in the blood. but may increase D in the tissue
  • Zinc is, however, essential to make Vitamin D Receptors and utilize Omega-3
  • Low zinc is associated with many autoimmune diseases,infections, colds, etc
  • Zinc, like Boron, is extremly low-cost and safe
  • Zinc category has 79 items

Unfortunately cofactors as pills are costly and typically need to be taken daily

Perspective of the importance of Vit D and co-factors to health

Importance to Health VDW10426


See also VitaminDWiki

See also - Excellent reviews of supplements at ConsumerLab

short URL = is.gd/Dplus


Genes can restrict Vitamin D from getting to the cells

Even if vitamin D levels are OD (e.g. > 40 nanogram)
Genetics category listing contains the following

307 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain

Additional Vitamin D information

   from Increased visibility for VitaminDWiki pages

VitaminDWiki pageComment
VitaminDWiki: Your Go-To Vitamin D Website - 2019
Does Less Sun mean More Disease 5 minute video summary
Some people have problems with vitamin D Typically low Magnesium
One pill every two weeks gives you all the vitamin D most adults need 50,000 IU every 2 weeks
Vitamin D bulb for use in the home - or perhaps office
Vitamin D from low-cost UVB lamps
Hearing Loss appears to be prevented and treated with vitamin D
Vitamin D reduces hair loss - many studies
Headache with vitamin D may mean you need Magnesium
60,000 IU vitamin D weekly with daily Calcium was safe but not enough in the winter – 2012
Vitamins To Speed Up Metabolism And Aid Weight Loss – May 2011
Low cost vitamin D Blood Tests
Gallbladder removal and vitamin D deficiencyIf Gallbladder has been removed
must take some other form of Vit D
Water soluable, etc.
Many reasons why vitamin D deficiency has become epidemic 35 reasons,
20 are new during the past 40 years
Intervention - Vitamin D 270 Vitamin D intervention studies
Diseases that are related via low vitamin D
Reasons for low response to vitamin D
Heart Attack ICU costs reduced $37,000 by $20 of Vitamin D – Nov 2015Example of huge Return On Investements
Vitamin D sprayed inside cheeks 2X more response (poor gut) – RCT Oct 2015
Do not expect a doctor to recommend a pill which will eliminate his job (vitamin D) "It is difficult to get a man to understand
something when his salary is dependent upon
his not understanding it"

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