Pediatr Diabetes. 2019 Sep;20(6):750-758. doi: 10.1111/pedi.12878. Epub 2019 Jul 2.
Nam HK1, Rhie YJ2, Lee KH3.
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- CYP2R1 (vitamin D 25-hydroxylase ) semiactivates vitamin D in many places in the body
- Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D – Oct 2013
- CYP2R1 mutations also cause vitamin D-deficient rickets – July 2016
- Vitamin D insufficiency was 3.7 X more likely if CYP2R1 gene variation– June 2014
- Lung Cancer (NSLC) more lethal if poor Vitamin D gene ( CYP2R1) – Oct 2019
- Poor CYP2R1 gene reduces blood response to Vitamin D supplementation – Aug 2019
- Response to Vitamin D varied by 12 ng due to gene variants (CYP2R1) – Aug 2019
- CYP2R1 and GC variations decrease vitamin D response – PHD thesis Nov 2015
- GC, CYP2R1 and DHCR7 genes associated with low vitamin D levels in China – 2012, 2013
- GC and CYP2R1 genes associated with higher summer vitamin D levels – Jan 2013
- Increased risk of diabetes if have poor Vitamin D genes – Dec 2020
- Poor CYP2R1 gene results in lower vitamin D and 2X increase in T1 Diabetes – Sept 2019
- Fasting and Diabetes both reduce Vitamin D activation (CYP2R1 in rodents) – May 2019
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Diabetes changes liver genes so as to destroy (catabolize) Vitamin D – May 2016
- Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016
- Diabetics with 8ng less vitamin D had a 50 percent increase chance of DHCR7 gene variation – Jan 2014
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- Fructose reduces blood levels of active vitamin D
- Type 1 diabetes, genes and vitamin D
- Vitamin D genes and insulin resistance – MS Aug 2010
Vitamin D metabolism has been associated with type 1 diabetes.
We aimed to clarify the association of 25-hydroxylase (CYP2R1) and 1α-hydroxylase (CYP27B1) with risk of developing type 1 diabetes in Korean children.
In total, 252 children (96 type 1 diabetes and 156 healthy controls) under the age of 20 years were recruited. Serum 25-hydroxyvitamin D (25OHD) and 1α,25-dihydroxyvitamin D [1α,25(OH)2 D] levels were determined. Allelic, genotypic, and haplotypic distribution of CYP2R1 (rs12794714, rs10766196, rs10741657, rs2060793, and rs10766197) and CYP27B1 (rs4646536, rs10877012, and rs3782130) polymorphisms were determined. Clinical and biochemical data were analyzed according to genotype.
Mean vitamin D level was considerably lower, and vitamin D deficiency was more prevalent in children with type 1 diabetes than in healthy controls. The GG genotype of CYP2R1 rs12794714 and AA genotype of CYP2R1 rs10766196 were significantly associated with risk of developing type 1 diabetes (odds ratio 2.00, 95% confidence interval 1.176-3.413 and odds ratio 1.88, 95% confidence interval 1.103-3.195, respectively). The GG+GA genotype of CYP2R1 rs12794714 and AA+AG genotype of CYP2R1 rs10766196 were associated with prevalent vitamin D deficiency in children with type 1 diabetes. These genotypes did not differ with respect to glycosylated hemoglobin and daily insulin requirement.
Serum 25OHD and 1α,25(OH)2 D levels were lower in children with type 1 diabetes than in healthy controls. CYP2R1 rs12794714 and rs10766196 polymorphisms were associated with a higher risk of type 1 diabetes. Thus, polymorphisms in vitamin D metabolism may contribute to susceptibility to type 1 diabetes in Korean children.