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Rickets is typically due to little Vitamin D getting the cells - April 2024

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Diagnosis, treatment, and management of rickets: a position statement from the Bone and Mineral Metabolism Group of the Italian Society of Pediatric Endocrinology and Diabetology

Front Endocrinol (Lausanne) . 2024 Apr 19:15:1383681. doi: 10.3389/fendo.2024.1383681
Giampiero I Baroncelli # 1, Pasquale Comberiati # 1 2, Tommaso Aversa 3 4, Federico Baronio 5, Alessandra Cassio 5 6, Mariangela Chiarito 7, Mirna Cosci O di Coscio 1, Luisa De Sanctis 8, Natascia Di Iorgi 9 10, Maria Felicia Faienza 7, Danilo Fintini 11, Roberto Franceschi 12, Mila Kalapurackal 13, Silvia Longhi 13, Michela Mariani 11, Marco Pitea 14, Andrea Secco 15, Daniele Tessaris 8, Francesco Vierucci 16, Malgorzata Wasniewska 3, Giovanna Weber 14, Stefano Mora 17 Italy

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Rickets results from impaired mineralization of growing bone due to alterations in calcium and phosphate homeostasis. Clinical signs of rickets are related to the age of the patient, the duration of the disease, and the underlying disorder. The most common signs of rickets are swelling of the wrists, knees or ankles, bowing of the legs (knock-knees, outward bowing, or both) and inability to walk. However, clinical features alone cannot differentiate between the various forms of rickets. Rickets includes a heterogeneous group of acquired and inherited diseases. Nutritional rickets is due to a deficiency of vitamin D, dietary calcium or phosphate. Mutations in genes responsible for vitamin D metabolism or function, the production or breakdown of fibroblast growth factor 23, renal phosphate regulation, or bone mineralization can lead to the hereditary form of rickets. This position paper reviews the relevant literature and presents the expertise of the Bone and Mineral Metabolism Group of the Italian Society of Pediatric Endocrinology and Diabetology (SIEDP). The aim of this document is to provide practical guidance to specialists and healthcare professionals on the main criteria for diagnosis, treatment, and management of patients with rickets. The various forms of rickets are discussed, and detailed references for the discussion of each form are provided. Algorithms to guide the diagnostic approach and recommendations to manage patients with rare forms of hereditary rickets are proposed.
 Download the PDF from VitaminDWiki


Rickets Genes and Genetics chart from VitaminDWiki

Image in Visio for 2023
Note: <13% of Genetic causes of rickets are due to Vitamin D genes (Perplexity AI)


VitaminDWiki – Overview of Rickets and vitamin D contains

Rate of rickets is usually < 0.1% of births, unless dark skin, breastfed, preemie, twin, Mongolian, or Russian
Rate of rickets has greatly increased with the drop in vitamin D levels during the past 40 years
400 IU can prevent/treat most rickets Turkey gave vitamin D to EVERY child and eliminated Rickets
Can have rickets without a low serum level of vitamin D (~20% of the time)
Giving enough Vitamin D to the mother (before and after birth) PREVENTS most forms of Rickets
Rate of rickets in some countries varies from 10% to 70% (typically poor health overall)
Rickets has been more than doubling in many countries
Rickets is strongly associated with severe breathing problems (weak ribs)
Bowed legs is not the primary indication of rickets    (3 other indications of rickets are seen more often)
Rickets is typically due to low cellular Vitamin D - April 2024
Some Rickets is due to poor genes - Vitamin D needed lifelong – June 2020
Vitamin D and Rickets consensus took 80 years

Rickets category has 128 items

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Breathing

History

Turkey

Mongolia

Other countries

Rickets - World

  • Nutritional rickets around the world: an update - 2016
    PDF is available free at Sci-Hub   10.1080/20469047.2016.1248170
    Nigeria 1 in 170; Gambia 1 in 70; Bangladesh 1 in 12

Recent Increase

Prevention and treatment

Shaken-baby syndrome

Associated with Dark skin and breastfed

Animals

Rickets Other

How much Vitamin D needed to stop rickets

Other Vitamin D

Attached files

ID Name Comment Uploaded Size Downloads
21179 Rickets D 2024.webp admin 06 May, 2024 13.62 Kb 16
21178 Rickets 2024.webp admin 06 May, 2024 29.81 Kb 20
21177 Rickets evaluation.webp admin 06 May, 2024 39.69 Kb 17
21175 Rickets 2024_CompressPdf.pdf admin 06 May, 2024 332.82 Kb 5