Loading...
 
Translate Register Log In Login with facebookLogin and Register

Genes account for less than 18 percent of variation in vitamin D levels – Jan 2013

Exploring the genetic architecture of circulating 25-hydroxyvitamin D.

Genet Epidemiol. 2013 Jan;37(1):92-8. doi: 10.1002/gepi.21694. Epub 2012 Nov 7.
Hiraki LT1, Major JM, Chen C, Cornelis MC, Hunter DJ, Rimm EB, Simon KC, Weinstein SJ, Purdue MP, Yu K, Albanes D, Kraft P.

The primary circulating form of vitamin D is 25-hydroxy vitamin D (25(OH)D), a modifiable trait linked with a growing number of chronic diseases. In addition to environmental determinants of 25(OH)D, including dietary sources and skin ultraviolet B (UVB) exposure, twin- and family-based studies suggest that genetics contribute substantially to vitamin D variability with heritability estimates ranging from 43% to 80%. Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) located in four gene regions associated with 25(OH)D. These SNPs collectively explain only a fraction of the heritability in 25(OH)D estimated by twin- and family-based studies. Using 25(OH)D concentrations and GWAS data on 5,575 subjects drawn from five cohorts, we hypothesized that genome-wide data, in the form of (1) a polygenic score comprised of hundreds or thousands of SNPs that do not individually reach GWAS significance, or (2) a linear mixed model for genome-wide complex trait analysis, would explain variance in measured circulating 25(OH)D beyond that explained by known genome-wide significant 25(OH)D-associated SNPs. GWAS identified SNPs explained 5.2% of the variation in circulating 25(OH)D in these samples and there was little evidence additional markers significantly improved predictive ability. On average, a polygenic score comprised of GWAS-identified SNPs explained a larger proportion of variation in circulating 25(OH)D than scores comprised of thousands of SNPs that were on average, nonsignificant. Employing a linear mixed model for genome-wide complex trait analysis explained little additional variability (range 0-22%). The absence of a significant polygenic effect in this relatively large sample suggests an oligogenetic architecture for 25(OH)D.

PMID: 23135809
 Download the PDF from VitaminDWiki. 2% to 18% in the PDF


There may be more variability between test results from blood on same type of tester than from genes

Is the true value 48 nmol -1090 tests @ /is.gd/vitd1090
Click on chart for details

See also VitaminDWiki

Short url = http://is.gd/genevitd

Attached files

ID Name Comment Uploaded Size Downloads
4817 Heritability 2013.pdf PDF 2013 admin 03 Jan, 2015 23:50 68.41 Kb 661
See any problem with this page? Report it (FINALLY WORKS)