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Human Leukocyte Antigen (HLA) gene problem is associated with Autism, Vitiligo, T1 Diabetes, Celiac, etc

Autism, Leishmaniasis, Vitiligo, Psoriasis, Graves' disease, rheumatoid arthritis, celiac disease, ankylosing spondylitis, T1 diabetes, myasthenia gravis, Sjögren syndrome, mold toxicity, thyroiditis, etc.


Inheritance of HLA-Cw7 Associated With Autism Spectrum Disorder (ASD) – Sept 2019

Front. Psychiatry 10:612. doi: 10.3389/fpsyt.2019.00612

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Not all Autistics have HLA-Cw7 problems.
Only some Autistics have HLA-Cw7 positive features and not negative features
HLA-Cw7 might be a subtype of all Autisms

Terry Harville12 Bobbie Rhodes-Clark1, Sirish C. Bennuri35, Leanna Delhey4’5,
John Slattery6, Marie Tippett35, Rebecca Wynne7, Shannon Rose35, Stephen Kahler35 and Richard E. Frye8'9*
1 Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, United States,2 Department of internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 3 Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 4 School of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 5 Arkansas Children’s Research institute, Little Rock, AR, United States, 6 BioRosa Technologies inc, San Francisco, CA, United States, 7 National Center for Toxicological Research, Jefferson, AR, United States,8 Barrow Neurological institute at Phoenix Children’s Hospital, Phoenix, AZ, United States,9 Department of Child Health, University of Arizona College of Medicine, Phoenix, AZ, United States

Autism spectrum disorder (ASD) is a behaviorally defined disorder that is now thought to affect approximately 1 in 69 children in the United States. In most cases, the etiology is unknown, but several studies point to the interaction of genetic predisposition with environmental factors. The immune system is thought to have a causative role in ASD, and specific studies have implicated T lymphocytes, monocytes, natural killer (NK) cells, and certain cytokines. The human leukocyte antigen (HLA) system is involved in the underlying process for shaping an individual’s immune system, and specific HLA alleles are associated with specific diseases as risk factors. In this study, we determine whether a specific HLA allele was associated with ASD in a large cohort of patients with ASD. Identifying such an association could help in the identification of immune system components which may have a causative role in specific cohorts of patients with ASD who share similar specific clinical features. Specimens from 143 patients with ASD were analyzed with respect to race and ethnicity. Overall, HLA-Cw7 was present in a much greater frequency than expected in individuals with ASD as compared to the general population. Further, the cohort of patients who express HLA-Cw7 shares specific immune system/inflammatory clinical features including being more likely to have allergies, food intolerances, and chronic sinusitis as compared to those with ASD who did not express HLA-Cw7. HLA-Cw7 has a role in stimulating NK cells. Thus, this finding may indicate that chronic over-activation of NK cells may have a role in the manifestation of ASD in a cohort of patients with increased immune system/inflammatory features.
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Human Leukocyte Antigen – 1 hour podcast

Dr. Donohoe

  • “Human leukocyte antigens (HLAs) can be found on the surface of most cells of the body. They are a method of categorising one's 'tissue type' and they play a role in determining a person's immune response to foreign substances

[00:54] Welcome back Mark Donohoe
[01:26] What is Human Leukocyte Antigen (HLA)
[05:34] The changing clinical significance of HLA
[08:36] Immunology and reproduction
[10:22] Genetic diversity
[13:21] HLA subtypes: mould and mycotoxins
[18:50] HLA inheritance
[20:50] Clinical value in screening
[40:32] Diseases/Disorders relevant to HLA
[46:34] Medicine interfering in evolution
[49:56] HLA and thyroid disorders
[54:36] Psoriasis and delayed drug reactions
[1:01:14] Determining when to screen for HLA?
[1:03:45] Final summary and resources


HLA-B and Autism in Thailand – 2017

Significant Association of HLA-B Alleles and Genotypes in Thai Children with Autism Spectrum Disorders: A Case-Control Study
Disease Markers, Volume 2015, Article ID 724935, 7 pages. http://dx.doi.org/10.1155/2015/724935 FREE PDF
Apichaya Puangpetch,1,2 Pongwut Suwannarat,1,2 Montri Chamnanphol,1,2 Napatrupron Koomdee,1,2 Nattawat Ngamsamut,3 Penkhae Limsila,3 and Chonlaphat Sukasem1,2

Autism is a severe neurodevelopmental disorder. Many susceptible causative genes have been identified. Most of the previous reports showed the relationship between the Human Leukocyte Antigen (HLA) gene and etiology of autism. In order to identify HLA-B alleles associated with autism in Thai population, we compared the frequency of HLA-B allele in 364 autistic subjects with 952 normal subjects by using a two-stage sequence-specific oligonucleotide probe system (PCR-SSOP) method based on flow- cytometry technology. HLA-B'13:02 (P = 0.019, OR = 2.229), HLA-B'38:02 (P = 0.049, OR = 1.628), HLA-B'44:03 (P = 0.016, OR = 1.645), and HLA-B'56:01 (P = 1.78 x 10-4, OR = 4.927) alleles were significantly increased in autistic subjects compared with normal subjects. Moreover, we found that the HLA-B' 18:02 (P = 0.016, OR = 0.375) and HLA-B'46:12 (P = 0.008, OR = 0.147) alleles were negatively associated with autism when compared to normal controls. Both alleles might have a protective role in disease development. In addition, four HLA-B genotypes of autistic patients had statistically significant relationship with control groups, consisting of HLA-B'3905/'5801 (P = 0.032, OR = 24.697), HLA-B'2704/'5801 (P = 0.022, OR = 6.872), HLA-B'3501/'4403 (P = 0.021, OR = 30.269), and HLA-B' 1801/'4402 (P = 0.017, OR = 13.757). This is the first report on HLA-B associated with Thai autism and may serve as a marker for genetic susceptibility to autism in Thai population.
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Immune Dysfunction in Autism Spectrum Disorder – 2011 (HLA occurs 54 times)

Free PDF online

  • “Stubbs & Magenis (1980) first suggested over 30 years ago that the human leukocyte antigen (HLA) region might be involved in autism”

HLA and Disease Associations – Book, 1985

Amazon $11,   472 pages
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Wonder if there has been an increase some diseases due to poor HLA genes being passed on to children?

Before: Autism, Leishmaniasis, Vitiligo, Graves' disease, celiac disease, ankylosing spondylitis, T1 diabetes, myasthenia gravis, Sjögren syndrome, thyroiditis, etc. would not be inherited, but now it is a possibility.

Created by admin. Last Modification: Monday November 18, 2019 23:54:07 GMT-0000 by admin. (Version 13)

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ID Name Comment Uploaded Size Downloads
13002 HLA book.jpg admin 18 Nov, 2019 17:42 16.20 Kb 40
13001 HLA B.pdf admin 18 Nov, 2019 17:18 1.22 Mb 23
13000 Positive.jpg admin 18 Nov, 2019 17:17 54.10 Kb 58
12999 HLA-Cw7 ASD.pdf PDF 2019 admin 18 Nov, 2019 17:17 1.08 Mb 21
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