Allergy. 2011 Nov;66(11):1442-8. doi: 10.1111/j.1398-9995.2011.02681.x. Epub 2011 Aug 5.
Liu X, Wang G, Hong X, Wang D, Tsai HJ, Zhang S, Arguelles L, Kumar R, Wang H, Liu R, Zhou Y, Pearson C, Ortiz K, Schleimer R, Holt PG, Pongracic J, Price HE, Langman C, Wang X.
Mary Ann and J. Milburn Smith Child Health Research Program, Children's Memorial Hospital, Children's Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. xnliu at childrensmemorial.org
BACKGROUND: It has been hypothesized that vitamin D deficiency (VDD) contributes to the development of food sensitization (FS) and then food allergy. However, the epidemiological evidence is conflicting. We aim to examine whether cord blood VDD is associated with FS and whether such association can be modified by genetic variants in a prospective birth cohort.
METHODS: This study included 649 children who were enrolled at birth and followed from birth onward at the Boston Medical Center. We defined VDD as cord blood 25(OH)D < 11 ng/ml, and FS as specific IgE ? 0.35 kUA/l to any of eight common food allergens in early childhood. We genotyped potentially functional single-nucleotide polymorphisms (SNPs) in 11 genes known to be involved in regulating IgE and 25(OH)D concentrations. Logistic regressions were used to test the effects of VDD on FS individually and jointly with SNPs.
RESULTS: Among the 649 children, 44% had VDD and 37% had FS.
When examined alone, VDD was not associated with FS.
When examined jointly with SNPs, a significant interaction between IL4 gene polymorphism (rs2243250) and VDD (p(interaction) = 0.003, p(FDR) = 0.10) was found:
VDD increased the risk of FS among children carrying CC/CT genotypes (OR = 1.79, 95%CI: 1.15-2.77).
Similar but weaker interactions were observed for SNPs in MS4A2 (rs512555), FCER1G (rs2070901), and CYP24A1 (rs2762934).
When all four SNPs were simultaneously considered, a strong gene-VDD interaction was evident (p(interaction) = 9 × 10(-6) ).
CONCLUSIONS: Our data demonstrate that VDD may increase the risk of FS among individuals with certain genotypes, providing evidence of gene-vitamin D interaction on FS.
© 2011 John Wiley & Sons A/S.
- - - - - - - - - - -
- All items in category Genetics and Vitamin D 52 items as June 2012
- 90 % of the genes in your body are NOT human These other genes were not considered in this study
- 229 Genes related to vitamin D - Aug 2010
- Vitamin D insufficiency 2.5X more likely with three genes – Lancet July 2010 with comments
- Hypothesis: adolescent allergies associated with low vitamin D levels
- 3X more allergy to peanuts if child born with low UV – Feb 2011
- 2X more allergies if 11th womb week was in Spring – Vitamin D or pollen Oct 2010
- Review of vitamin D asthma and allergic diseases – abstract lacks details July 2010
- Vitamin D may be linked to food allergies by intestinal flora – July 2010