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Response to Vitamin D varies with genes (3,000 IU, weight loss in this RCT) – March 2022

Vitamin D Supplementation and Genetic Polymorphisms Impact on Weight Loss Diet Outcomes in Caucasians: A Randomized Double-Blind Placebo-Controlled Clinical Study

Front Med (Lausanne). 2022 Mar 3;9:811326. doi: 10.3389/fmed.2022.811326. eCollection 2022.
Konstantinos Xenos 1 2 3, Maria Papasavva 2, Athanasios Raptis 2, Martha-Spyridoula Katsarou 2, Nikolaos Drakoulis 2

None of gene mutations resulted in a statistically significant changes in this small study



Vitamin D deficiency or insufficiency is common in obese people, with some studies suggesting that low vitamin D level might be an independent predictor of obesity. Thus, the purpose of the present randomized, double-blind, placebo-controlled study was to investigate the effect of oral spray vitamin D3 3000 IU supplementation along with personalized weight-loss diet on obesity markers in overweight and obese Caucasians with vitamin d deficiency or insufficiency. The impact of vitamin D receptor (VDR) and adrenergic receptors (ADRs) genetic variants on vitamin D levels and weight loss diet outcomes was also investigated. After signing informed consent, a total of 125 eligible volunteers were randomly assigned into vitamin D (vitamin D3 3000 IU/d oral spray supplementation, n = 76) or placebo (xylitol, water, mint, n = 49) group following a weight loss program (600 calories less than the total energy expenditure of each volunteer) for 3 months. Fat mass, BMI, REE and 25(OH)D serum level were monitored on baseline and each month. DNA samples were extracted from buccal swabs and genotyped for the rs2228570 (VDR), rs1544410 (VDR), rs731236 (VDR), rs1800544 (ADRA2A), rs1801252 (ADRB1), rs1042713 (ADRB2), and rs4994 (ADRB3) polymorphisms. Statistical analysis was performed using SPSS package (v.23). Between group comparisons revealed significant improvement in serum 25(OH)D level and greater reduction in weight, BMI and fat percentage in the vitamin D group compared to placebo group (p < 0.05). In the vitamin D group, carriers of the rs2228570 T allele tended to have greater vitamin D level improvement compared with the homozygous C allele (p = 0.067). Furthermore, heterozygous (CT) for the rs731236 tended to have lesser weight loss (p = 0.068) and for the rs1042713, a lower decline in fat percentage was observed for homozygous AA carriers compared to the heterozygous (p = 0.051). In the control group, differences in weight loss (p = 0.055) and BMI (p = 0.045) were observed between rs1544410 AA and GG homozygous. In conclusion, vitamin D oral spray supplementation seems to improve vitamin D status and decrease obesity markers during a weight-loss intervention in overweight/obese Caucasians with vitamin D deficiency or insufficiency. Also, the results of the present study indicate that VDR and ADRs genetic polymorphisms seem to influence vitamin D supplementation response and obesity markers.
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VitaminDWiki Obesity RCTs: 33 items

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VitaminDWiki Obesity amd Genes: 18 items

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Created by admin. Last Modification: Tuesday March 22, 2022 12:38:53 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
17280 Vit D change 2228570.jpg admin 22 Mar, 2022 35.22 Kb 88
17279 Wt loss 731236.jpg admin 22 Mar, 2022 34.55 Kb 205
17278 wt loss.jpg admin 22 Mar, 2022 32.76 Kb 245
17277 BMI 1544410.jpg admin 22 Mar, 2022 34.69 Kb 198
17276 Gene influences not statistically significant.jpg admin 22 Mar, 2022 49.90 Kb 253
17275 Weight Loss Vit D, genes.pdf admin 22 Mar, 2022 1.21 Mb 228