Table of contents
- Genetic factors help explain the variable responses of young children with cystic fibrosis to vitamin D supplements
- See related studies in VitaminDWiki
- VitaminDWiki - Genetics category contains
- VitaminDWiki - Vitamin D Binding Protein category contains
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Genetic factors help explain the variable responses of young children with cystic fibrosis to vitamin D supplements
Clin Nutr ESPEN 2022 Oct;51:367-376. doi: 10.1016/j.clnesp.2022.07.018
HuiChuan J Lai 1 , Jie Song 2 , Qiongshi Lu 3 , Sangita G Murali 4 , Manavalan Gajapathy 5 , Brandon M Wilk 5 , Donna M Brown 5 , Elizabeth A Worthey 5 , Philip M Farrell 6 , FIRST Study GroupBackground & aims: Children with cystic fibrosis (CF) are susceptible to fat-soluble vitamin deficiencies unless supplemented, but even large doses of vitamin D may not prevent low 25-hydroxyvitamin D (25OHD) concentrations. The explanation for these vitamin D non-responders has been elusive. We utilized data from whole genome sequencing (WGS) to test the hypothesis that genetic variations predict responsiveness to vitamin D supplementation in a prospective cohort study of children with CF in the first 3 years of life.
Methods: One hundred and one infants born during 2012-2017 and diagnosed with CF through newborn screening were studied. Serum 25OHD concentrations and vitamin D supplement doses were assessed during early infancy and annually thereafter. WGS was performed, the resultant variant calling files processed, and the summary statistics from a recent genome-wide association study were utilized to construct a polygenic risk score (PRS) for each subject.
Results: Overall, the prevalence of vitamin D insufficiency (<30 ng/mL) was 21% in the first 3 years of life. Among the 70 subjects who always adhered to vitamin D supplement doses recommended by the US CF Foundation guidelines, 89% were responders (achieved vitamin D sufficiency) by 3 years of age, while 1% were transient or non-responders. Multiple regression analysis revealed that PRS was a significant predictor of 25OHD concentrations (p < 0.001) and the likelihood of being an earlier responder in the first 3 years of life (p < 0.01). A limited SNP analysis revealed variants in four important genes (GC, LIPC, CYP24A1, and PDE3B) that were shown to be associated with 25OHD concentrations and vitamin D responder status. Other determinants included vitamin D supplement dose, season at 25OHD measurement, and pancreatic functional status.
Conclusions: Applying WGS in conjunction with utilizing a PRS approach revealed genetic variations that partially explain the unresponsiveness of some children with CF to vitamin D supplementation. Our findings suggest that a nutrigenomics strategy could help promote personalized treatment in CF.
See related studies in VitaminDWiki
- No response to Vitamin D was 11 X more likely to have if poor Binding gene – Sept 2022 = GC
- Boron improves magnesium absorption and may help vitamin D non-responders – Aug 2015
- 10 reasons for poor response to Vitamin D (race, binding protein, etc.) – Nov 2017
- Vitamin D Nutrigenomics - High, Medium, and Low Responders - March 2019
- CYP24A1 in title (31 as of Sept 2022)
- Rare mutation of CYP24A1 gene results in Vitamin D accumulating
- Vitamin D accumulation in 1 in 300 people due to gene (CYP24A1) can cause Calcium problems – June 2018
- Reasons for low response to vitamin D
- Huge variation in response to vitamin D supplementation – personal vitamin D response index – Dec 2016 Carlberg
- Figure 2A daily dose of 3,200 IU
VitaminDWiki - Genetics category contains
343 articles in the Genetics category see also
- Vitamin D Receptor has
526 items - Vitamin D Binding Protein = GC has
177 items - CYP27B1 has
63 items - CYP24A1 in title of 34+ items
- CYP2R1 25+ items
- Calcidiol has
48 items - Calcitriol has
60 items - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (7 as of Dec 2022)
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication) Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family
especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
3) DNA and VDR tests - 120 to 200 dollars $100 to $250
4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
Genes are good, have enough Magnesium, etc.
5) Back Pain
probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc- The founder of VitaminDWiki took action with clues #3&5
VitaminDWiki - Vitamin D Binding Protein category contains
177 items Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D
There have been
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