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Neuro problems (AD, PD, MSA) associated with poor vitamin D genes (CYP27A1, CYP27B1) – Sept 2022

Role of cytochrome P450 for vitamin D metabolisms in patients with neurodegenerative disorders

Clinical Parkinsonism & Related Disorders Volume 7, 2022, 100162 https://doi.org/10.1016/j.prdoa.2022.100162
AsakoKakimotoabHiromuOguraaMidoriSuenagacTakayasuMishimaaShinsukeFujiokaaShinjiOumaaYoichiMatsunagaa YoshioTsuboia


  • Low serum concentrations of CYP27A1 in AD, PD and MSA patients.
  • Low serum concentrations of CYP27B1 in MSA patients.
  • Serum P450 concentrations affect VD metabolites in neurodegenerative disorders.

We previously reported lower serum 25-hydroxyvitamin D concentrations in patients with Alzheimer’s disease (AD), Parkinson’s disease (PD) and Multiple system atrophy (MSA) compared to healthy controls (HC), whereas 1,25-di-hydroxyvitamin D levels were solely lower in MSA patients. We investigate serum concentrations of P450 involved in Vitamin D(VD) hydroxylation to clarify the responsible hydroxylase for the low serum concentrations of VD metabolites.

A total of 79 individuals were enrolled including 20 HC, 20 AD, 19 PD and 20 MSA patients. The serum concentrations of P450 involved in VD hydroxylation were assayed by ELISA. The data were analyzed by the nonparametric Kruskal-Wallis test between groups.

Though CYP2R1 and CYP27A1 mediate 25-hydroxylation for VD, CYP2R1 is the main hydroxylase, and CYP27A1 is also involved in VD synthesis. CYP2R1 concentrations showed no differences among groups, while lower CYP27A1 concentrations were found in PD (p < 0.05) and MSA (p < 0.005) compared to HC and differences between AD and MSA (p < 0.05), however no differences between PD and MSA. CYP27B1 is the main 1α-hydroxylase for 25-hydroxyvitamin D and showed differences between HC and PD (p < 0.05), between HC and MSA (p < 0.005) and between PD and MSA (p = 0.055). CYP24A1, which inactivate 1,25-di-hydroxyvitamin D, showed no differences among groups.

CYP27A1 might affect VD synthesis and cause low 25-hydroxyvitamin D levels in AD, PD and MSA patients. Low 1,25-di-hydroxyvitamin D levels in MSA patients might be caused by impaired feedback mediated by CYP27B1.
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VitaminDWik - CYP27B1 category contains

The CYP27B1 gene activates Vitamin D in the Kidney,    Skin,    Lungs,    Brain,   Eyes   Breasts   etc.
CYtochrome P450 family 27 subfamily B member 1    = 25-Hydroxyvitamin D3 1-alpha-hydroxylase

Vitamin D blood test misses CYP27B1 and other genes
in Visio for 2023

Genetics category listing contains the following

327 articles in the Genetics category

see also

Vitamin D blood test misses a lot
in Visio for 2023

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain

VitaminDWiki - 9 studies in both categories Cognition and Genetics

This list is automatically updated

Wonder why this study did not consider the Vitamin D Receptor (which limites Vitamin D getting to cells)

VitaminDWiki - 16 studies in both categories Cognition and Vitamin D Receptor

This list is automatically updated

VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D contains

VitaminDWiki - Overview Parkinson's and Vitamin D contains

Created by admin. Last Modification: Thursday September 8, 2022 17:52:39 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
18395 CYP Neurodegen.jpg admin 08 Sep, 2022 17:25 36.05 Kb 192
18394 Vit D Genes and neurodegenerative disorders.pdf PDF 2022 admin 08 Sep, 2022 17:24 481.80 Kb 84