Low levels of vitamin D poorly responsive to daylight exposure in patients with therapy-resistant schizophrenia.
Nord J Psychiatry. 2016;70(4):262-6. doi: 10.3109/08039488.2015.1086023. Epub 2015 Nov 17.
P A M Bogers J1, Bostoen T2, G Broekman T3.
1 Jan P.A.M. Bogers, Mental Health Services Rivierduinen , High Care Clinics , Oegstgeest , the Netherlands.
2 Tijmen Bostoen, Mental Health Services Rivierduinen , High Care Clinics , Oegstgeest , the Netherlands.
3 Theo G. Broekman, Bureau Beta , Nijmegen , the Netherlands.
I do not recall seeing this association before for any vitamin D related disease.
Is this is related to a Vitamin D gene?
Items in both categories Noontime Sun and Cognition are listed here:
- Little sun in first trimester, 2.9 X more likely to have learning disabilities – June 2019
- Fewer cognitive problems if more sun or Vitamin D
- Alzheimer’s associated with low sun and low vitamin D – Sept 2018
- Less vitamin D generated from sunlight by schizophrenia patients – 2016
- Fewer cognitive problems in regions with more sunshine (vitamin D) – April 2014
Overview Schizophrenia and Vitamin D contains the following summary
Many reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
13) Schizophrenia risk is decreased if give Vitamin D after birth
14) Schizophrenia symptoms reduced when Vitamin D levels are restored
Genetics category listing contains the following
- Vitamin D Receptor has
- Vitamin D Binding Protein = GC has
- CYP27B1 has
- CYP24A1 in title (31 as of Sept 2022)
- Calcidiol has
- Calcitriol has
- Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (6 as of June 2022)
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family
- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain
- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of VitaminDWiki took action with clues #3&4
Low vitamin D levels are associated with schizophrenia, but the possible association between vitamin D levels and illness severity or duration of exposure to daylight has barely been investigated.
To compare vitamin D levels in therapy-refractory severely ill schizophrenia patients and members of staff. To investigate the influence of daylight exposure on vitamin D levels in patients.
Vitamin D was measured in patients with therapy-resistant schizophrenia in April, after the winter, and in patients and staff members in June, after an exceptionally sunny spring. Vitamin D levels in April and June were compared in patients, and levels in June were compared in patients and staff. The influence of daylight was taken into account by comparing the time patients spent outdoors during the day with the recommended minimum time for adequate vitamin D synthesis, and by comparing time spent outdoors in patients and staff.
Patients had high rates of vitamin D deficiency (79-90%) and lower levels of vitamin D than staff members (p < 0.001), independent of skin pigmentation. In patients, vitamin D levels did not normalize, despite the considerably longer than recommended exposure of the skin to daylight (p?<?0.001) and the longer exposure in patients than in staff members (p = 0.003).
The vitamin D deficiency of therapy-resistant schizophrenia patients is pronounced and cannot be explained by differences in skin pigmentation or by an inactive, indoor lifestyle on the ward. Even theoretically sufficient exposure of the patients to daylight did not ameliorate the low vitamin D levels.
While vitamin D deficiency probably plays a role in somatic health problems, it may also play a role in schizophrenia. Interestingly, exposure to daylight during an unusually sunny spring was not sufficient to correct the vitamin D deficiency seen in the patients. This emphasizes the need to measure and correct vitamin D levels in these patients.
PMID: 27010382 DOI: 10.3109/08039488.2015.1086023Less vitamin D generated from sunlight by schizophrenia patients – 2016
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- Vitamin D Binding Protein = GC has