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Infertility is also associated with poor Vitamin D Binding Protein – Oct 2017

Vitamin D binding protein is lower in infertile patients compared to fertile controls: a case control study

Fertility Research and Practice20173:14, https://doi.org/10.1186/s40738-017-0042-0
Jason Franasiak, Sue Shapses, Wei Sun, Richard Scott and Xiangbing Wang

Premenopausal women (from table 2)

Infertile Fertile
25OHD (ng/mL)
standard test, no difference
30 30
DBP (mg/dL) 40.* 53 
Free 25OHD (pg/mL) 6.3 * 4.3 
Bioavailable 25OHD (ng/mL) 3 2 
Estradiol (pg/mL) 116* 45
  • P < 0.01 = statistically significant
VitaminDWiki

Vitamin D binding protein(GC) and the Vitamin D Receptors (VDR) are two of the genes which restrict how much Vitamin D actually gets to cells . For both gene problems an easy solution (improved fertility in this case) is to just increase the amount of vitamin D consumed.
Note: gene problems in the male can also lead to infertility of the couple

Genetics category listing contains the following

232 articles in the Genetics category

see also 260 articles in Vitamin D Receptor, 96 articles in Vitamin D Binding Protein

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki - (subject to many future developments)
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, andi in 2017 is speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells appears feasible (personal communication)
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 47+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
        easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4


 Download the PDF from VitaminDWiki

Background
The importance of vitamin D in general health as well as in human reproductive success has been an area of focus. A better understanding of vitamin D metabolism, particularly vitamin D binding protein, is important when elucidating this relationship.

Methods
This case control trial seeks to characterize vitamin D metabolism in infertile patients undergoing natural cycle IVF as compared to normally cycling premenopausal women with proven fertility matched for age and body mass index (BMI). A total of 68 subjects were examined; 39 were infertile premenopausal women and 29 were regularly cycling fertile controls. Their 25-hydroxy vitamin D (25OHD), vitamin D binding protein (DBP), and albumin were measured and free and bioavailable 25OHD calculated. Between group comparisons were conducted with an unpaired t-test. A stepwise regression using age, BMI, 25OHD, estradiol & albumin in the model were used to determine predictors of DBP.

Results
Age, BMI, and total 25OHD did not differ between the two groups. However, vitamin D binding protein, free and bioavailable vitamin D were significantly different in the infertile patients as compared to the regularly cycling fertile controls (p < 0.01). Stepwise Regression using age, BMI, 25OHD, estradiol & albumin in the model showed that only albumin was a predictor of DBP (β-coefficient − 0.310; p = 0.01).

Conclusion
The implications of lower vitamin D binding protein associated with infertility is not clear from this pilot study, and requires further study.

Created by admin. Last Modification: Saturday October 14, 2017 10:41:45 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
8549 Infertility DBP.pdf PDF 2017 admin 14 Oct, 2017 10:28 344.18 Kb 94
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