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Infertility is also associated with poor Vitamin D Binding Protein – Oct 2017

Vitamin D binding protein is lower in infertile patients compared to fertile controls: a case control study

Fertility Research and Practice20173:14, https://doi.org/10.1186/s40738-017-0042-0
Jason Franasiak, Sue Shapses, Wei Sun, Richard Scott and Xiangbing Wang

Premenopausal women (from table 2)

Infertile Fertile
25OHD (ng/mL)
standard test, no difference
30 30
DBP (mg/dL) 40.* 53 
Free 25OHD (pg/mL) 6.3 * 4.3 
Bioavailable 25OHD (ng/mL) 3 2 
Estradiol (pg/mL) 116* 45
  • P < 0.01 = statistically significant

Vitamin D binding protein(GC) and the Vitamin D Receptors (VDR) are two of the genes which restrict how much Vitamin D actually gets to cells . For both gene problems an easy solution (improved fertility in this case) is to just increase the amount of vitamin D consumed.
Note: gene problems in the male can also lead to infertility of the couple

Genetics category listing contains the following

266 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki as of early 2019
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain

 Download the PDF from VitaminDWiki

The importance of vitamin D in general health as well as in human reproductive success has been an area of focus. A better understanding of vitamin D metabolism, particularly vitamin D binding protein, is important when elucidating this relationship.

This case control trial seeks to characterize vitamin D metabolism in infertile patients undergoing natural cycle IVF as compared to normally cycling premenopausal women with proven fertility matched for age and body mass index (BMI). A total of 68 subjects were examined; 39 were infertile premenopausal women and 29 were regularly cycling fertile controls. Their 25-hydroxy vitamin D (25OHD), vitamin D binding protein (DBP), and albumin were measured and free and bioavailable 25OHD calculated. Between group comparisons were conducted with an unpaired t-test. A stepwise regression using age, BMI, 25OHD, estradiol & albumin in the model were used to determine predictors of DBP.

Age, BMI, and total 25OHD did not differ between the two groups. However, vitamin D binding protein, free and bioavailable vitamin D were significantly different in the infertile patients as compared to the regularly cycling fertile controls (p < 0.01). Stepwise Regression using age, BMI, 25OHD, estradiol & albumin in the model showed that only albumin was a predictor of DBP (β-coefficient − 0.310; p = 0.01).

The implications of lower vitamin D binding protein associated with infertility is not clear from this pilot study, and requires further study.

Created by admin. Last Modification: Tuesday October 15, 2019 12:01:39 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
8549 Infertility DBP.pdf PDF 2017 admin 14 Oct, 2017 10:28 344.18 Kb 278
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