Vitamin D supplementation alters the expression of genes associated with hypertension and did not induce DNA damage in rats.
J Toxicol Environ Health A. 2019 Mar 25:1-15. doi: 10.1080/15287394.2019.1592044.
Machado CDS1,2, Ferro Aissa A3, Ribeiro DL1, Antunes LMG3.
Search VitaminDWiki for hypertension (CYP2r1 OR DHCR7) 509 items as of March 2019
Items in both categories Hypertension and Genetics are listed here:
- Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020
- Hypertension 3.1 X more likely in males with poor CPY24A1 gene (but 2.5 X less likely for females) – May 2019
- Hypertension gene expression reduced by high-dose vitamin D (hypertensive rats) – March 2019
- Hypertension associated with genes which reduce vitamin D – meta-analysis June 2014
Items in both categories Hypertension and Vitamin D Binding Protein are listed here:
Items in both categories Hypertension and Vitamin D Receptor are listed here:
Vitamin D3 deficiency has been correlated with altered expression of genes associated with increased blood pressure (BP); however, the role of vitamin D3 supplementation in the genetic mechanisms underlying hypertension remains unclear. Thus, the aim of this study was investigate the consequences of vitamin D3 supplemented (10,000 IU/kg) or deficient (0 IU/kg) diets on regulation of expression of genes related to hypertension pathways in heart cells of spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) controls.
An additional aim was to assess the impact of vitamin D3 on DNA damage and oxidative stress markers. The gene expression profiles were determined by PCR array, DNA damage was assessed by an alkaline comet assay, and oxidative stress markers by measurement of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) levels. In SHR rats data showed that the groups of genes most differentially affected by supplemented and deficient diets were involved in BP regulation and renin-angiotensin system. In normotensive WKY controls, the profile of gene expression was similar between the two diets. SHR rats were more sensitive to changes in gene expression induced by dietary vitamin D3 than normotensive WKY animals. In addition to gene expression profile, vitamin D3 supplemented diet did not markedly affect DNA or levels of TBARS and GSH levels in both experimental groups. Vitamin D3 deficient diet produced lipid peroxidation in SHR rats. The results of this study contribute to a better understanding of the role of vitamin D3 in the genetic mechanisms underlying hypertension.
Abbreviations: AIN, American Institute of Nutrition; EDTA, disodium ethylenediaminetetraacetic acid; GSH, glutathione; PBS, phosphate buffer solution; SHR, spontaneously hypertensive rats; TBARS, thiobarbituric acid reactive substances; WKY, Wistar Kyoto.