Vitamin D Status, Receptor Gene Polymorphisms, and Supplementation on Tuberculosis:
A Systematic Review of Case-Control Studies and Randomized Controlled Trials
Journal of Clinical & Translational Endocrinology, DOI: http://dx.doi.org/10.1016/j.jcte.2014.08.001
Nilay Sutariaemail, Ching-Ti Liuemail, Tai C. Chenemail
Received: May 23, 2014; Received in revised form: July 25, 2014; Accepted: August 7, 2014; Published Online: August 15, 2014
•Lower serum 25-hydroxyvitamin D increases susceptibility to tuberculosis.
•BsmI and FokI VDR gene polymorphisms may confer increased risk of acquiring tuberculosis.
•Vitamin D supplementation reduces tuberculosis incidence and increases recovery from tuberculosis.
To investigate the impacts of vitamin D status, supplementation and vitamin D receptor (VDR) gene polymorphisms on tuberculosis (TB).
We conducted a systematic review of published studies pertaining to case-control and randomized-control trials from 2002 to 2014 using the PubMed database.
Results and conclusion:
Individuals with TB have lower vitamin D status than healthy individuals. Some VDR gene polymorphisms are associated with increased susceptibility to TB while others may not. Supplementation with vitamin D leads to improved clinical outcomes. However, further studies with a larger patient population and different ethnicities are needed to confirm these effects.
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ALL random controlled trial showed reduction of TB when Vitamin D was added
unless there was a very long time between doses (5 months) or very small doses of vitamin D were used (800 IU/day)