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Tuberculosis, Genes, Vitamin D Binding Protein, and RCT – Review Aug 2014

Vitamin D Status, Receptor Gene Polymorphisms, and Supplementation on Tuberculosis:
A Systematic Review of Case-Control Studies and Randomized Controlled Trials

Journal of Clinical & Translational Endocrinology, DOI: http://dx.doi.org/10.1016/j.jcte.2014.08.001
Nilay Sutariaemail, Ching-Ti Liuemail, Tai C. Chenemail
Received: May 23, 2014; Received in revised form: July 25, 2014; Accepted: August 7, 2014; Published Online: August 15, 2014


•Lower serum 25-hydroxyvitamin D increases susceptibility to tuberculosis.
•BsmI and FokI VDR gene polymorphisms may confer increased risk of acquiring tuberculosis.
•Vitamin D supplementation reduces tuberculosis incidence and increases recovery from tuberculosis.

To investigate the impacts of vitamin D status, supplementation and vitamin D receptor (VDR) gene polymorphisms on tuberculosis (TB).

We conducted a systematic review of published studies pertaining to case-control and randomized-control trials from 2002 to 2014 using the PubMed database.

Results and conclusion:
Individuals with TB have lower vitamin D status than healthy individuals. Some VDR gene polymorphisms are associated with increased susceptibility to TB while others may not. Supplementation with vitamin D leads to improved clinical outcomes. However, further studies with a larger patient population and different ethnicities are needed to confirm these effects.

PDF is attached at the bottom of this page

ALL random controlled trial showed reduction of TB when Vitamin D was added
unless there was a very long time between doses (5 months) or very small doses of vitamin D were used (800 IU/day)

See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
4289 TB review.pdf PDF 2014 admin 18 Aug, 2014 13:13 459.10 Kb 735
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