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COVID-19 lung infection upsets Vitamin D genes (so more or different form of Vit D is required) - Dec 22, 2020

Evidence of a dysregulated Vitamin D pathway in SARS-CoV-2 infected patient's lung cells

PrePrint: doi: https://doi.org/10.1101/2020.12.21.423733
Bijesh George, Ravikumar Amjesh, Aswathy Mary Paul, Santhosh Kumar TR, Madhavan Radhakrishna Pillai, Rakesh Kumar

VitaminDWiki
  • Health problems that have learned to de-regulate the Vitamin D metabolism require higher blood levels of Vitamin D
  • COVID-19 affects the CYP27A1 gene, which results in less Vitamin D to be produced in the blood
  • The CYP27A1 gene can be bypassed in two ways
    • Topical or mucosal Vitamin D - dissolve Vitamin D powder in water or use nanoemulsion
    • Semi-activated Vitamin D (Calcidiol) which was found to be very successful in one clinical trial
      • Note: Calcidiol is high cost and prescription-only for humans, but is available at low cost to animal doctors
  • There are 10+ ways to increase the Vitamin D Receptor activation

Genetics category listing contains the following

273 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki as of early 2019
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain

Items in both categories Virus and Vitamin D Receptor:

Items in both categories Virus and Genetics:

 Download the PDF from VitaminDWiki

Many genes regulated by Vitamin D are de-regulated by lungs with COVID-19 infection
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Vitamin D Receptor
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Although a defective vitamin D pathway has been widely suspected to be associated in SARS-CoV-2 pathobiology, the status of the vitamin D pathway and vitamin D-modulated genes in lung cells of patients infected with SARS-CoV-2 remains unknown. To understand the significance of the vitamin D pathway in SARS-CoV-2 pathobiology, computational approaches were applied to transcriptomic datasets from bronchoalveolar lavage fluid (BALF) cells of such patients or healthy individuals.
Levels of vitamin D receptor, retinoid X receptor, and CYP27A1 in BALF cells of patients infected with SARS-CoV-2 were found to be reduced.
Additionally, 107 differentially expressed, predominantly downregulated genes modulated by vitamin D were identified in transcriptomic datasets from patient's cells. Further analysis of differentially expressed genes provided eight novel genes with a conserved motif with vitamin D-responsive elements, implying the role of both direct and indirect mechanisms of gene expression by the dysregulated vitamin D pathway in SARS-CoV-2-infected cells. Network analysis of differentially expressed vitamin D-modulated genes identified pathways in the immune system, NF-KB;cytokine signaling, and cell cycle regulation as top predicted pathways that might be affected in the cells of such patients. In brief, the results provided computational evidence to implicate a dysregulated vitamin D pathway in the pathobiology of SARS-CoV-2 infection.


This preprint was reviewed in Medical News Net


Created by admin. Last Modification: Thursday December 24, 2020 04:01:40 GMT-0000 by admin. (Version 12)

Attached files

ID Name Comment Uploaded Size Downloads
14771 COVID VDR.jpg admin 24 Dec, 2020 00:13 73.08 Kb 170
14770 43 genes.jpg admin 24 Dec, 2020 00:12 92.23 Kb 186
14769 Evidence of a dysregulated Vitamin D pathway in SARS-CoV-2.pdf PDF 2020 admin 24 Dec, 2020 00:12 533.30 Kb 87
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