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Colon cancer more likely in blacks due to differences in Vitamin D genes (wonder if more Vitamin D would help) – May 2014


Cancer Causes Control. 2014 May;25(5):561-70. doi: 10.1007/s10552-014-0361-y. Epub 2014 Feb 23.
Pibiri F1, Kittles RA, Sandler RS, Keku TO, Kupfer SS, Xicola RM, Llor X, Ellis NA.

PURPOSE:
Disparities in both colorectal cancer (CRC) incidence and survival impact African Americans (AAs) more than other US ethnic groups. Because vitamin D is thought to protect against CRC and AAs have lower serum vitamin D levels, genetic variants that modulate the levels of active hormone in the tissues could explain some of the cancer health disparity. Consequently, we hypothesized that genetic variants in vitamin D-related genes are associated with CRC risk.
METHODS:
To test this hypothesis, we studied 39 potentially functional single-nucleotide polymorphisms (SNPs) in eight genes (CYP2R1, CYP3A4, CYP24A1, CYP27A1, CYP27B1, GC, DHCR7, and VDR) in 961 AA CRC cases and 838 healthy AA controls from Chicago and North Carolina. We tested whether SNPs are associated with CRC incidence using logistic regression models to calculate p values, odds ratios, and 95 % confidence intervals. In the logistic regression, we used a log-additive genetic model and used age, gender, and percent West African ancestry, which we estimated with the program STRUCTURE, as covariates in the models.
RESULTS:
A nominally significant association was detected between CRC and the SNP rs12794714 in the vitamin D 25-hydroxylase gene CYP2R1 (p = 0.019), a SNP that has previously been associated with serum vitamin D levels. Two SNPs, rs16847024 in the GC gene and rs6022990 in the CYP24A1 gene, were nominally associated with left-sided CRC (p = 0.015 and p = 0.018, respectively).
CONCLUSIONS:
Our results strongly suggest that genetic variation in vitamin D-related genes could affect CRC susceptibility in Aas.
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31+ VitaminDWiki Dark Skin pages have CANCER in the title

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Items found: 31
Title Modified
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Prostate cancer patients in Jamaica were 5X more likely to die of PC if low vitamin D - Sept 2022 01 Oct, 2022
Newly diagnosed Children with Cancer have low vitamin D, especially if black - May 2022 16 Jun, 2022
Cancer continues to be more deadly for Blacks than Whites (hint – low Vitamin D) – May 2022 30 May, 2022
Cancer of breast is highest in dark-skinned women (low Vitamin D: dark skin and obese) - Feb 2022 12 Feb, 2022
Cancers and Vitamin D Receptors, including change with race – Feb 2021 24 Oct, 2021
Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020 19 Feb, 2021
Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 10 Jan, 2021
Blacks are more obese, have lower Vitamin D, and have more Cancer etc. than whites – Feb 2018 03 May, 2018
Hypothesis: Blacks get more cancer than whites due to lower levels of vitamin D – June 2012 03 May, 2018
Prostate Cancer risk in black men increased 2X having poor Vitamin D Binding Protein – July 2017 20 Nov, 2017
Breast cancer in blacks – 5X increased risk of triple negative if low vitamin D – Oct 2017 01 Nov, 2017
Breast cancer worse for black women – Sept 2011 19 Aug, 2017
Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017 06 Mar, 2017
Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017 28 Dec, 2016
Head and Neck Cancer associated with low vitamin D, especially with blacks - April 2012 17 Nov, 2016
2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013 14 Nov, 2016
Higher rate of prostate cancer in AA may decrease if take vitamin D – July 2016 07 Jul, 2016
Prostate Cancer incidence and death 2X more often among black men (vitamin D not mentioned) - July 2015 30 Jul, 2015
Kidney Cancer differences with skin color probably due to vitamin D differences – May 2015 25 May, 2015
Tanning potential predicts risk of Prostate Cancer in Blacks – Nov 2014 02 Jan, 2015
Cancer patients at high risk of vitamin D deficiency were not tested as often (paradoxically) – July 2014 12 Aug, 2014
Colon cancer more likely in blacks due to differences in Vitamin D genes (wonder if more Vitamin D would help) – May 2014 21 May, 2014
Barefoot on mega doses of vitamin D and his book on Cancer 10 Apr, 2014
Hypothesis - Dark skin evolved to avoid skin cancer - Feb 2014 02 Mar, 2014
Breast cancer more deadly for blacks than whites 13 Feb, 2014
Skin cancer risk and vitamin D from sun both decrease with darker skin – March 2013 10 Nov, 2013
Hypothesis: Vitamin D is related to breast cancer racial disparities in the US - Sept 2012 08 Jul, 2013
Genes may account for some of AA Breast Cancer – April 2012 08 Jul, 2013
More US deaths due to cancer than heart if dark skinned – Sept 2012 18 Sep, 2012
Low vitamin D in blacks increases colorectal cancer deaths 40 percent – Cancer Oct 2010 23 Oct, 2010

Attached files

ID Name Comment Uploaded Size Downloads
3930 colorectal cancer A-A.pdf admin 21 May, 2014 245.89 Kb 920