Cancer Causes Control. 2014 May;25(5):561-70. doi: 10.1007/s10552-014-0361-y. Epub 2014 Feb 23.
Pibiri F1, Kittles RA, Sandler RS, Keku TO, Kupfer SS, Xicola RM, Llor X, Ellis NA.
Disparities in both colorectal cancer (CRC) incidence and survival impact African Americans (AAs) more than other US ethnic groups. Because vitamin D is thought to protect against CRC and AAs have lower serum vitamin D levels, genetic variants that modulate the levels of active hormone in the tissues could explain some of the cancer health disparity. Consequently, we hypothesized that genetic variants in vitamin D-related genes are associated with CRC risk.
To test this hypothesis, we studied 39 potentially functional single-nucleotide polymorphisms (SNPs) in eight genes (CYP2R1, CYP3A4, CYP24A1, CYP27A1, CYP27B1, GC, DHCR7, and VDR) in 961 AA CRC cases and 838 healthy AA controls from Chicago and North Carolina. We tested whether SNPs are associated with CRC incidence using logistic regression models to calculate p values, odds ratios, and 95 % confidence intervals. In the logistic regression, we used a log-additive genetic model and used age, gender, and percent West African ancestry, which we estimated with the program STRUCTURE, as covariates in the models.
A nominally significant association was detected between CRC and the SNP rs12794714 in the vitamin D 25-hydroxylase gene CYP2R1 (p = 0.019), a SNP that has previously been associated with serum vitamin D levels. Two SNPs, rs16847024 in the GC gene and rs6022990 in the CYP24A1 gene, were nominally associated with left-sided CRC (p = 0.015 and p = 0.018, respectively).
Our results strongly suggest that genetic variation in vitamin D-related genes could affect CRC susceptibility in Aas.
PDF is attached at the bottom of this page
Pages listed in BOTH of the categories Colon cancer and Dark Skin
Pages listed in BOTH of the categories Cancer and Dark Skin
- Cancers and Vitamin D Receptors, including change with race – Feb 2021
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
- More US deaths due to cancer than heart if dark skinned – Sept 2012
- Hypothesis: Blacks get more cancer than whites due to lower levels of vitamin D – June 2012