Common Variants in CYP2R1 and GC Genes Predict Vitamin D Concentrations in Healthy Danish Children and Adults.
PLoS One. 2014 Feb 27;9(2):e89907. doi: 10.1371/journal.pone.0089907. eCollection 2014.
Nissen J1, Rasmussen LB1, Ravn-Haren G2, Andersen EW3, Hansen B4, Andersen R1, Mejborn H1, Madsen KH1, Vogel U5.
Environmental factors such as diet, intake of vitamin D supplements and exposure to sunlight are known to influence serum vitamin D concentrations. Genetic epidemiology of vitamin D is in its infancy and a better understanding on how genetic variation influences vitamin D concentration is needed. We aimed to analyse previously reported vitamin D-related polymorphisms in relation to serum 25(OH)D concentrations in 201 healthy Danish families with dependent children in late summer in Denmark. Serum 25(OH)D concentrations and a total of 25 SNPs in GC, VDR, CYP2R1, CYP24A1, CYP27B1, C10or88 and DHCR7/NADSYN1 genes were analysed in 758 participants. Genotype distributions were in Hardy-Weinberg equilibrium for the adult population for all the studied polymorphisms. Four SNPs in CYP2R1 (rs1562902, rs7116978, rs10741657 and rs10766197) and six SNPs in GC (rs4588, rs842999, rs2282679, rs12512631, rs16846876 and rs17467825) were statistically significantly associated with serum 25(OH)D concentrations in children, adults and all combined. Several of the SNPs were in strong linkage disequilibrium, and the associations were driven by CYP2R1-rs10741657 and rs10766197, and by GC-rs4588 and rs842999. Genetic risk score analysis showed that carriers with no risk alleles of CYP2R1-rs10741657 and rs10766197, and/or GC rs4588 and rs842999 had significantly higher serum 25(OH)D concentrations compared to carriers of all risk alleles. To conclude, our results provide supporting evidence that common polymorphisms in GC and CYP2R1 are associated with serum 25(OH)D concentrations in the Caucasian population and that certain haplotypes may predispose to lower 25(OH)D concentrations in late summer in Denmark.
Download the PDF from VitaminDWiki.
- Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D – Oct 2013
- GC and CYP2R1 genes associated with higher summer vitamin D levels – Jan 2013
- Mice lacking CYP2R1 enzyme activate about half of much vitamin D – Sept 2013
- Genetics category listing with associated searches
- CYP2R1 gene probably responsible for low vitamin D response – RCT April 2014
- Search VitaminDWiki for Cyp2R1 190 hits Oct 2014,
- GC gene 1450 hits as of June 2019
- Predict Vitamin D category listing has
65 items along with related searches
Items in both categories Genetics and Predict Vitamin D are listed here:
Gene differences can result in 14 ng difference in vitamin D levels– Feb 2014
- Vitamin D Nutrigenomics - High, Medium, and Low Responders - March 2019
- Huge variation in response to vitamin D supplementation – personal vitamin D response index – Dec 2016
- Molecular Approaches for Optimizing Vitamin D (one size does not fit all) – Carlberg Nov 2015
- Genes account for less than 18 percent of variation in vitamin D levels – Jan 2013
- Some people need more vitamin D to get the same response – perhaps due to genes – Nov 2014
- Gene differences can result in 14 ng difference in vitamin D levels– Feb 2014
- Might be able to predict who will benefit from vitamin D by just 2 genes – July 2013
3783 visitors, last modified 06 Jun, 2019,This page is in the following categories (# of items in each category)Genetics 278 Top news 831 Predict Vitamin D 65