The synergistic effect between adult weight changes and CYP24A1 polymorphisms is associated with pre- and postmenopausal breast cancer risk.
Breast Cancer Res Treat. 2019 Nov 6. doi: 10.1007/s10549-019-05484-6
Items in both of the categories of Vitamin D Receptor gene which restricts Vitamin D AND Obesity
- Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in the case) – July 2024
- Obesity decreases BOTH Vitamin D levels and Vitamin D Receptor activation – Oct 2023
- Risk of sleep apnea in obese increases 3.4X with poor vitamin D Receptor – Sept 2021
- Large weight loss 32X more likely to be achieved if weight gain was due to Vitamin D Receptor – Jan 2020
- Obesity 2X higher risk if a poor Vitamin D Receptor (13th study) – Dec 2019
- Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
- Obesity associated with poor Vitamin D genes (VDR in this study) – Jan 2018
- Skin fold thickness but not BMI associated with poor Vitamin D Receptor in Han Chinese – April 2018
- Resveratrol improves health (Vitamin D receptor, etc.)
- Obesity might be related to Vitamin D genes – July 2018
- Obesity 1.5 X more likely if poor Vitamin D receptor – Dec 2017
- Obesity in 700 young adults associated with a poor Vitamin D Receptor – Jan 2018
- Obese are 30 percent more likely to have poor Vitamin D Receptor – Aug 2017
- Vitamin D restricted in getting to cells by genes, obesity, etc – Jan 2017
- Vitamin D Receptor and Obesity – many studies
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Obesity strongly associated with vitamin D receptor in Saudia Arabia – July 2014
Items in both of the categories of Genetics AND Obesity
- Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in the case) – July 2024
- Obese children have poor vitamin D genes (CYP27A1, CYP2R1, CYP27B1) – March 2024
- Obese children had less gene methylation (gene not work as well) – March 2024
- Response to Vitamin D varies with genes (3,000 IU, weight loss in this RCT) – March 2022
- High-fat diet reduces CYP2R1 gene needed to make semi-activated vitamin D (mice) – Aug 2021
- Hypothesis: Obesity reduces Vitamin D production by repressing CYP2R1 gene in liver and fat tissue – July 2020
- Increased risk of weight gain when gene restricts Vitamin D getting to tissues (CYP24A1 in this case) – Nov 2019
- Obesity associated with poor Vitamin D genes (VDR in this study) – Jan 2018
- Gut genes related to important disease changed in Obese with 2,000 IU for 12 weeks – May 2019
- Obesity cut semi-activation of Vitamin D in half (mice) – Jan 2019
- Obesity might be related to Vitamin D genes – July 2018
- Vitamin D restricted in getting to cells by genes, obesity, etc – Jan 2017
- Multiple Sclerosis and obesity share some gene problems (as well as low vitamin D) – June 2016
- Vitamin D may block the obesity gene (FTO) – Jan 2014
- Vitamin D roles in obesity: genetics and cell signaling – June 2013
- Obese have 50 percent less of two enzymes in fatty tissue to process vitamin D – May 2013
- No apparent genetic association between vitamin D and obesity – Feb 2013
- Genes indicate that Obesity causes vitamin D deficiency – Feb 2013
Cao S1, Wei F2, Zhou J3, Zhu Z3, Li W1, Wu M4,5.
1 Department of Epidemiology and Health Statistics, Southeast University, Nanjing, China.
2 Department of Oncology, Southeast University, Nanjing, China.
3 Department of Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Road 72th, Nanjing, 210009, Jiangsu, China.
4 Department of Epidemiology and Health Statistics, Southeast University, Nanjing, China. jswuming at vip.sina.com.
5 Department of Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Road 72th, Nanjing, 210009, Jiangsu, China. jswuming at vip.sina.com.
PURPOSE:
Vitamin D (VD) metabolism regulates adipose tissue, lipogenesis inflammation, and tumor growth. CYP24A1 is the key enzyme for metabolic inactivation of active VD (1,25(OH)2D3). We examined whether common germline single nucleotide polymorphisms (SNPs) in the CYP24A1 gene could affect the association between adult weight gain and breast cancer (BC) risk.
METHODS:
The population-based case-control study included 818 patients with primary BC and 935 residence and age matched healthy controls. We studied the relationships between CYP24A1 gene SNPs (rs2209314, rs2585428, rs2762941, rs3787555, rs4809959, rs73913757, rs912505, and rs927a650), adult weight change and BC risk. Gene-weight change interactions were analyzed.
RESULTS:
Neither of CYP24A1 gene SNPs was associated with BC risk in the study participants. However, we found consistent gene-weight interactions with increasing adult weight gain for CYP24A1-rs2762941 (P-interaction = 0.0089) and CYP24A1-rs927650 (P-interaction = 0.0283). Adult weight gain has a higher premenopausal BC risk with double variant T alleles of rs927650 compared to women carrying at least one wild-type C allele (OR for TT = 1.82, 95% CI 1.10-3.01; for CT = 0.93, 95% CI 0.76-1.14; for CC = 1.12 95% CI 0.93-1.35). Women with double wild-type A alleles were at a higher postmenopausal BC risk compared to those carrying at least one variant-type G allele (OR for
- AA = 1.51, 95% CI 1.29-1.76; for
- AG = 1.13, 95% CI 0.98-1.30; for
- GG = 1.22 95% CI 0.95-1.57).
When stratified by CYP24A1 SNPs genotypes, weight gain in adulthood increased postmenopausal BC risk of women with homozygous allele compared to women with heterozygotes allele.
CONCLUSION:
Significant interactions of weight change with CYP24A1 polymorphisms suggest CYP24A1 as a potential link between weight change and BC risk and the possibility that the impact of adult weight gain on postmenopausal BC risk may be enhanced by homozygous alleles of CYP24A1 SNPs.