The Impact of CYP24A1 Polymorphisms on Hypertension Susceptibility.
Kidney Blood Press Res. 2020 Jan 9:1-10. doi: 10.1159/000503925.
A poor CYP24A1 gene destroys fully activated Vitamin D
A Vitamin D blood test measures semi-activated Vitamin D
CYP24A1 enzyme and Vitamin D - many studies
Items in both categories Hypertension and Genetics are listed here:
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020
- Hypertension 3.1 X more likely in males with poor CPY24A1 gene (but 2.5 X less likely for females) – May 2019
- Hypertension gene expression reduced by high-dose vitamin D (hypertensive rats) – March 2019
- Hypertension associated with genes which reduce vitamin D – meta-analysis June 2014
Items in both categories Hypertension and Vitamin D Receptor are listed here:
- Health problems running in family may be due to poor vitamin D (hypertension, VDR in this case) Sept 2022
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Hypertension risk increased 2.1 X if poor Vitamin D Receptor – Dec 2019
- Helicobacter pylori infection and low vitamin D – several studies
- Hypertension, Vitamin D, and Vitamin D Receptor – Aug 2019
- Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019
- Hypertension, Vitamin D Receptor, and FokI gene – Editorial Aug 2014
Genetics category listing contains the following
see also
- Vitamin D Receptor has
470 items - Vitamin D Binding Protein = GC has
169 items - CYP27B1 has
53 items - CYP24A1 in title (32 as of Oct 2022)
- CYP24R1 25+ items
- Calcidiol has
42 items - Calcitriol has
56 items - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (7 as of Dec 2022)
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of VitaminDWiki took action with clues #3&4
Cancers might alter CYP24A1 gene
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Bao Q1, Wang D1, Zhang Y1, Bao L1, Jia H2.
1 Gerontological Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
2 Gerontological Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China, jiahaiyu0228 at 163.com.BACKGROUND:
Hypertension is one of the leading causes of human death and disability. CYP24A1 regulates vitamin D activity and is closely linked to hypertension. However, the relationship between CYP24A1polymorphisms and hypertension risk remains unclear.METHODS:
This case-control study included 503 hypertensive patients and 498 healthy controls from the Chinese Han population. The genotypes of CYP24A1 polymorphisms were detected using the Agena MassARRAY method. The association between genetic variations of CYP24A1and hypertension risk was evaluated with odds ratios (OR) and 95% confidence intervals (CI) in genetic models.RESULTS:
We found that rs56229249 of CYP24A1significantly decreased the hypertension risk in homozygote (OR 0.51, 95% CI 0.29-0.91, p = 0.022) and recessive models (OR 0.51, 95% CI 0.29-0.91, p = 0.023). Further stratification analyses indicated that hypertension risk is related to age and sex, rs2762934 polymorphism increases hypertension risk among younger subjects (<61 years), and rs1977297 influences the risk of hypertension among older subjects (≥61 years). In addition, rs2762940 is related to hypertension risk in men, and rs56229249 is a protective factor against hypertension in women.CONCLUSIONS:
Our study suggests that genetic variations of the CYP24A1gene were significantly associated with susceptibility to hypertension in the Chinese population.Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020Printer Friendly Follow this page for updates2266 visitors, last modified 15 Jan, 2020, This page is in the following categories (# of items in each category)Attached files
ID Name Comment Uploaded Size Downloads 13336 HT CYP24A1.jpg admin 15 Jan, 2020 12:59 31.89 Kb 368 13335 Hypertension CYP24A1.pdf PDF 2020 admin 15 Jan, 2020 12:59 465.42 Kb 358 - Vitamin D Binding Protein = GC has