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Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020

The Impact of CYP24A1 Polymorphisms on Hypertension Susceptibility.

Kidney Blood Press Res. 2020 Jan 9:1-10. doi: 10.1159/000503925.

VitaminDWiki

A poor CYP24A1 gene destroys fully activated Vitamin D
A Vitamin D blood test measures semi-activated Vitamin D

CYP24A1 enzyme and Vitamin D

Items in both categories Hypertension and Genetics are listed here:

Items in both categories Hypertension and Vitamin D Receptor are listed here:


Genetics category listing contains the following

254 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki as of early 2019
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
        easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4

Cancers might alter CYP24A1 gene

 Download the PDF from VitaminDWiki
Image
Bao Q1, Wang D1, Zhang Y1, Bao L1, Jia H2.
1 Gerontological Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
2 Gerontological Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China, jiahaiyu0228 at 163.com.

BACKGROUND:
Hypertension is one of the leading causes of human death and disability. CYP24A1 regulates vitamin D activity and is closely linked to hypertension. However, the relationship between CYP24A1polymorphisms and hypertension risk remains unclear.

METHODS:
This case-control study included 503 hypertensive patients and 498 healthy controls from the Chinese Han population. The genotypes of CYP24A1 polymorphisms were detected using the Agena MassARRAY method. The association between genetic variations of CYP24A1and hypertension risk was evaluated with odds ratios (OR) and 95% confidence intervals (CI) in genetic models.

RESULTS:
We found that rs56229249 of CYP24A1significantly decreased the hypertension risk in homozygote (OR 0.51, 95% CI 0.29-0.91, p = 0.022) and recessive models (OR 0.51, 95% CI 0.29-0.91, p = 0.023). Further stratification analyses indicated that hypertension risk is related to age and sex, rs2762934 polymorphism increases hypertension risk among younger subjects (<61 years), and rs1977297 influences the risk of hypertension among older subjects (≥61 years). In addition, rs2762940 is related to hypertension risk in men, and rs56229249 is a protective factor against hypertension in women.

CONCLUSIONS:
Our study suggests that genetic variations of the CYP24A1gene were significantly associated with susceptibility to hypertension in the Chinese population.

Created by admin. Last Modification: Wednesday January 15, 2020 13:04:07 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
13336 HT CYP24A1.jpg admin 15 Jan, 2020 12:59 31.89 Kb 0
13335 Hypertension CYP24A1.pdf PDF 2020 admin 15 Jan, 2020 12:59 465.42 Kb 0
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