Kidney Blood Press Res. 2020 Jan 9:1-10. doi: 10.1159/000503925.
A poor CYP24A1 gene destroys fully activated Vitamin D
A Vitamin D blood test measures semi-activated Vitamin D
Items in both categories Hypertension and Genetics are listed here:
- Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020
- Hypertension 3.1 X more likely in males with poor CPY24A1 gene (but 2.5 X less likely for females) – May 2019
- Hypertension gene expression reduced by high-dose vitamin D (hypertensive rats) – March 2019
- Hypertension associated with genes which reduce vitamin D – meta-analysis June 2014
Items in both categories Hypertension and Vitamin D Receptor are listed here:
Genetics category listing contains the following
349 articles in Vitamin D Receptor 132 articles in Vitamin D Binding Protein = GC 28 articles in CYP27B1
Vitamin D blood test misses a lot
- Snapshot of the literature by VitaminDWiki as of early 2019
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
However test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family
especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain
probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
The founder of VitaminDWiki took action with clues #3&4
- Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014
- Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010
- 3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different – May 2012
- CYP24A1 gene in cancer cells may actually deactivate vitamin D – Oct 2012
Download the PDF from VitaminDWiki
Bao Q1, Wang D1, Zhang Y1, Bao L1, Jia H2.
1 Gerontological Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
2 Gerontological Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China, jiahaiyu0228 at 163.com.
Hypertension is one of the leading causes of human death and disability. CYP24A1 regulates vitamin D activity and is closely linked to hypertension. However, the relationship between CYP24A1polymorphisms and hypertension risk remains unclear.
This case-control study included 503 hypertensive patients and 498 healthy controls from the Chinese Han population. The genotypes of CYP24A1 polymorphisms were detected using the Agena MassARRAY method. The association between genetic variations of CYP24A1and hypertension risk was evaluated with odds ratios (OR) and 95% confidence intervals (CI) in genetic models.
We found that rs56229249 of CYP24A1significantly decreased the hypertension risk in homozygote (OR 0.51, 95% CI 0.29-0.91, p = 0.022) and recessive models (OR 0.51, 95% CI 0.29-0.91, p = 0.023). Further stratification analyses indicated that hypertension risk is related to age and sex, rs2762934 polymorphism increases hypertension risk among younger subjects (<61 years), and rs1977297 influences the risk of hypertension among older subjects (≥61 years). In addition, rs2762940 is related to hypertension risk in men, and rs56229249 is a protective factor against hypertension in women.
Our study suggests that genetic variations of the CYP24A1gene were significantly associated with susceptibility to hypertension in the Chinese population.