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Genome-wide view on the physiology of vitamin D – April 2014

Frontiers In Physiology – Integrative Physiology
Topic Editors: Carsten Carlberg, University of Eastern Finland, Finland

The main physiological actions of the biologically most active metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1α,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1α,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present different perspectives on the action of vitamin D and its receptor, such as the

  • impact of the genome-wide distribution of VDR binding loci,
  • ii) the transcriptome- and proteome-wide effects of vitamin D,
  • iii) the role of vitamin D in health,
  • iv) tissue-specific functions of vitamin D and
  • v) the involvement of vitamin D in different diseases,
    such as infections, autoimmune diseases, diabetes and different types of cancer.

Approximately 15 chapters will be provided by experts in the field.
For details please see the list of suggested titles.

List which follows

Interaction of vitamin D with membrane-based signaling pathways

María Jesús Larriba, José Manuel González-Sancho, Félix Bonilla and Alberto Muñoz; doi: 10.3389/fphys.2014.00060 ;Review Article, Published on 21 Apr 2014

Impact of vitamin D on immune function: lessons learned from genome-wide analysis

Rene F Chun, Philip T Liu, Robert L Modlin, John S Adams and Martin Hewison; doi: 10.3389/fphys.2014.00151
Review Article, Published on 09 Apr 2014 On VitaminDWiki

Vitamin D and gene networks in human osteoblasts

Jeroen van de Peppel and Johannes Van Leeuwen; doi: 10.3389/fphys.2014.00137; Review Article, Published on 03 Apr 2014

The future of vitamin D analogs

Carlien Leyssens, Lieve Verlinden and Annemieke Verstuyf; doi: 10.3389/fphys.2014.00122; Review Article, Published on 29 Apr 2014

Vitamin D and the epigenome

Irfete S. Fetahu, Julia Höbaus and Enikö Kallay; doi: 10.3389/fphys.2014.00164; Perspective Article, Published on 16 Apr 2014

The role of vitamin D in skeletal and cardiac muscle function full text online

Patsie Polly and Timothy Chiat-Choon Tan; doi: 10.3389/fphys.2014.00145; Review Article, Published on 29 Apr 2014

Genome-wide (over)view on the actions of vitamin D full text online

Carsten Carlberg; doi: 10.3389/fphys.2014.00167; Review Article

Tumour suppression in skin and other tissues via cross-talk between vitamin D- and p53-signalling

Joerg Reichrath, Sandra Reichrath, kristina Heyne, thomas vogt and klaus roemer; doi: 10.3389/fphys.2014.00166; Review Article

Vitamin D, intermediary metabolism and prostate cancer tumor progression

Wei Lin Winnie Wang and Martin Tenniswood; doi: 10.3389/fphys.2014.00183; Review Article

2.1. Structural considerations of vitamin D signaling

Ferdinand Molnár ;doi: 10.3389/fphys.2014.00191; Review Article

Vitamin D and the RNA transcriptome: more than mRNA regulation

Moray J Campbell; doi: 10.3389/fphys.2014.00181

See also VitaminDWiki

  • ((Molecular Approaches for Optimizing Vitamin D (one size does not fit all) – Carlberg Nov 2015)

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