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Poor Vitamin D response 4X more likely if poor Vitamin D binding proteins - July 2019

Efficacy of vitamin D supplementation according to vitamin D-binding protein polymorphisms.

Nutrition. 2019 Feb 19;63-64:148-154. doi: 10.1016/j.nut.2019.02.003.
Al-Daghri NM1, Mohammed AK2, Bukhari I3, Rikli M4, Abdi S5, Ansari MGA5, Sabico S5, Hussain SD5, Alenad A6, Al-Saleh Y4, Alokail MS6.


Poor response = < 20 ng after 8 weeks of 50,000 IU Vitmin D weekly
Poor response due to poor VDRP has been documented in many studies

Vitamin D Binding Protein category listing has 176 items has the following

Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

  • GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
  • The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
  • The actual D getting to the cells is a function of measured D and all 4 genes
  • There is >2X increase in 8+ health problems if have poor VDBP (GC)
  • It appears that VDBP only blocks oral vitamin D,

Genetics category listing contains the following

328 articles in the Genetics category

see also

Vitamin D blood test misses a lot
in Visio for 2023

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain

See also web

  • Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions - May 2019 doi: 10.3389/fendo.2019.00317 Free PDF

 Download the PDF from VitaminDWiki




OBJECTIVES: The aim of this study was to determine the influence of vitamin D-binding protein (DBP) gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation.

METHODS: In all, 234 participants (126 women; 108 men) with vitamin D deficiency [25(OH)D <50 nmol/L] were given 50 000 IU of vitamin D supplements for 8 wk followed by daily maintenance of 1000 IU for 4 mo. Two single-nucleotide polymorphisms (rs4588 and rs7041) in DBP coding gene were assessed.

RESULTS: Baseline 25(OH)D was significantly in higher in participants with homozygous major genotype of rs7041 than other genotypes (P = 0.02). Post supplementation 25(OH)D was significantly higher in participants with homozygous major genotypes of either rs4588 and rs7041 than other genotypes (P < 0.001).
Participants with the minor allele of either rs4588 or rs7041 were 2.9 (1.9-4.5) times and 3.7 (2.1-6.6) times, respectively, more likely to be non-responders (post supplementation 25 OHD <50 nmol/L) than those homozygous for the major allele at these locations (P < 0.001).

Furthermore, participants with homozygous minor and heterozygous genotype of rs7041 were 6.2 and 4.2 times more likely to be non-responders than those with the homozygous major genotype (P < 0.001) even after adjustments for age, sex, body mass index, baseline 25(OH)D concentration, and other alleles.
Participants with homozygous minor and heterozygous genotypes of rs4588 were 4.1 and 12.4 times more likely to be non-responders than those with homozygous major genotypes. These significant risks, however, were lost after adjustment.

CONCLUSIONS: rs7041 and rs4588 variants of the DBP gene are associated with variations in 25(OH)D levels and efficacy of response to vitamin D supplementation in Saudi Arabian adults.

Created by admin. Last Modification: Saturday June 15, 2019 01:48:13 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
11733 T5 VDBP.jpg admin 09 Apr, 2019 54.57 Kb 551
11731 non-responders.jpg admin 09 Apr, 2019 12.01 Kb 503
11730 vitamin D-binding protein polymorphisms.pdf admin 09 Apr, 2019 550.15 Kb 571