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Thyroid Cancer 1.9 X more likely if poor gene to generate Vitamin D from the sun (DHCR7) – July 2019

Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer.

Genes (Basel). 2019 Jul 28;10(8). pii: E572. doi: 10.3390/genes10080572.
Carvalho IS1, Gonçalves CI1, Almeida JT1, Azevedo T2, Martins T2, Rodrigues FJ2, Lemos MC3.

Vitamin D is mostly known for its role in bone and calcium metabolism. However, studies have suggested that it also has inhibitory effects on tumor development and progression. Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D. The aim of this case-control study was to determine the effect of these variants in the vitamin D pathway on the susceptibility to thyroid cancer. Five hundred patients with differentiated thyroid cancer and 500 controls were genotyped for the DHCR7 rs12785878, CYP2R1 rs2060793, and CYP24A1 rs6013897 variants. Genotype and allele frequencies were compared between patients and controls. The DHCR7 rs12785878 minor allele was associated with thyroid cancer under an additive (OR 1.38, 95% CI 1.15-1.65, p = 0.0004) and codominant (OR 1.88, 95% CI 1.30-2.74, p = 0.0021) model. These findings suggest that DHCR7 polymorphisms may be associated with an increased risk of thyroid cancer due to an effect of this gene on circulating vitamin D levels.
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VitaminDWiki    Cancer- Other category with THYROID in title (7 as of Olct 2022)

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