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Cytomegalovirus downregulates Vitamin D receptor, but tissues respond by increasing production – Sept 2016

HUMAN CYTOMEGALOVIRUS INFECTION DOWN REGULATES VITAMIN-D RECEPTOR IN MAMMALIAN CELLS

The Journal of Steroid Biochemistry and Molecular Biology, online 9 August 2016, doi:10.1016/j.jsbmb.2016.08.002

VitaminDWiki Summary

The Cytomegalovirus downregulates the Vitamin D Receptor by 8X in the lab
Human tissue compensates by increasing active Vitamin D production by 9.7 X
These changes have not been observed in other viruses.
See also VitaminDWiki
Vitamin D can inhibit enveloped virus such as Cytmo
Genetics category listing contains the following

254 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki as of early 2019
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
        easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4

Franz J.J. Riedera, Charlotte Gröschelb, Marie-Theres Kastnera, Karin Kosulinc, Johannes Laengled, Rene Zadnikare, Rodrig Marculescue, Martina Schneidera, Thomas Lionc, f, Michael Bergmannd, Enikö Kallayb, Christoph Steiningera, christoph.steininger at meduniwien.ac.at

Highlights

  • Vitamin D is essential for the human body including antimicrobial responses.
  • Cytomegalovirus infection downregulates VDR expression in vitro..
  • Expression of CYP24A1 decreases and of CYP27B1 increases in parallel.
  • VDR expression is not downregulated during influenza virus or adenovirus replication.
  • Cytomegalovirus may also influence VDR expression in vivo.

Vitamin D (VD) is essential for the human body and involved in a wide variety of critical physiological processes including bone, muscle, and cardiovascular health, as well as innate immunity and antimicrobial responses. Here, we elucidated the significance of the VD system in cytomegalovirus (CMV) infection, which is one of the most common opportunistic infections in immunocompromised or -suppressed patients.
We found that expression of vitamin D receptor (VDR) was downregulated in CMV-infected cells within 12 hours [hrs] post infection [p.i.] to 12 % relative to VDR expression in mock-infected fibroblasts and did not recover during the CMV replication cycle of 96 hrs. None of the biologically active metabolites of VD, cholecalciferol, calcidiol, or calcitriol, inhibit CMV replication significantly in human fibroblasts.
In a feedback loop, expression of CYP24A1 dropped to 3 % by 12 hrs p.i. and expression of CYP27B1 increased gradually during the replication cycle of CMV to 970 % probably as a consequence of VDR inhibition. VDR expression was not downregulated during influenza virus or adenovirus replication. The potent synthetic vitamin D analog EB-1089 was not able to inhibit CMV replication or antagonize its effect on VDR expression. Only CMV replication, and none of the other viral pathogens evaluated, inhibited the vitamin D system in vitro. In view of the pleiotropism of VDR, CMV-mediated downregulation may have far-reaching virological, immunological, and clinical implications and thus warrant further evaluations in vitro and in vivo.

Publisher wants $26 for the fascinating PDF
PDF also available at deepdyve.com

Clipped from PDF

  • “Vitamin D supplementation is beneficial for patients with HIV, hepatitis C virus, Chlamydia spp. Or mycobacterial infection”
  • “CMV infection downregulated VDR expression and this downregulation was specific for CMV and was not observed for other, common human viruses.”
  • “In solid-organ and bone-marrow transplant patients, CMV is the most common opportunistic virus infection with an incidence of up to 85 % and is associated with significant morbidity and mortality”
  • “VDR gene expression was even upregulated continuously during influenza virus infection. “


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However, Vitamin D receptor is UPREGULATED by adrenovirus

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See also web

CMV is very commen, but most people are unaware of it
http://www.ccc4w.com/CytomegalovirusCMVDisease.shtml
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CMV 1 in 150 people
https://www.nationalcmv.org/resources/blog/june-2016/national-cmv-awareness-month.aspx
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Attached files

ID Name Comment Uploaded Size Downloads
7066 CMV 1 in 150.jpg admin 11 Sep, 2016 18:18 38.64 Kb 716
7065 CMV births.jpg admin 11 Sep, 2016 18:18 59.23 Kb 650
7064 Cyto adreno.jpg admin 11 Sep, 2016 18:12 21.93 Kb 633
7063 Cyto Vit D.jpg admin 11 Sep, 2016 18:12 27.27 Kb 662
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