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Vitamin D effects on over 300 genes varies with genetics and levels – Dec 2020

Common and personal target genes of the micronutrient vitamin D in primary immune cells from human peripheral blood

Sci Rep. 2020 Dec 3;10(1):21051. doi: 10.1038/s41598-020-78288-0.
Andrea Hanel 1, Antonio Neme 2, Marjo Malinen 3, Emmi Hämäläinen 1, Henna-Riikka Malmberg 1, Stéphane Etheve 4, Tomi-Pekka Tuomainen 5, Jyrki K Virtanen 5, Igor Bendik 6, Carsten Carlberg 7

VitaminDWiki

Genetics category listing contains the following

278 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki as of early 2019
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain

An April 2020 paper by a few of the authors
Key Vitamin D Target Genes with Functions in the Immune System
 Download the PDF from VitaminDWiki

 Download the PDF from VitaminDWiki
Image

Vitamin D is essential for the function of the immune system. In this study, we treated peripheral blood mononuclear cells (PBMCs) of healthy adults with the biologically active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) using two different approaches: single repeats with PBMCs obtained from a cohort of 12 individuals and personalized analysis based on triplicates of five study participants. This identified 877 (cohort approach) and 3951 (personalized approach) genes that significantly (p < 0.05) changed their expression 24 h after 1,25(OH)2D3 stimulation. From these, 333 and 1232 were classified as supertargets, a third of which were identified as novel. Individuals differed largely in their vitamin D response not only by the magnitude of expression change but also by their personal selection of (super)target genes. Functional analysis of the target genes suggested the overarching role of vitamin D in the regulation of metabolism, proliferation and differentiation, but in particular in the control of functions mediated by the innate and adaptive immune system, such as responses to infectious diseases and chronic inflammatory disorders. In conclusion, immune cells are an important target of vitamin D and common genes may serve as biomarkers for personal responses to the micronutrient.


Created by admin. Last Modification: Saturday December 5, 2020 13:46:55 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
14674 Key Vitamin D Target Genes.pdf PDF 2020 admin 05 Dec, 2020 13:44 3.59 Mb 93
14673 Genes 1.jpg admin 05 Dec, 2020 13:30 91.46 Kb 59
14672 personal target genes.pdf PDF 2020 admin 05 Dec, 2020 13:29 2.90 Mb 70
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