Association Between CYP24A1 Polymorphisms and Bladder Cancer Risk in the Chinese Han Population
Biochemical Genetics https://doi.org/10.1007/s10528-024-10771-z PDF behind paywall and at DeepDyve
Tianyi Zhang, Baoping Hu, Shilin Xu, Yuhe Wang, Hengxun Zhang, Xuemei Li, Xuguang Li, Tianbo Jin & Yongjun He
In this cohort of 217 bladder cancer patients and 484 healthy controls, we explored the association between CYP24A1 variants (rs2762934, rs1570669, rs6068816, rs2296241) and bladder cancer risk in the Chinese Han population. Utilizing the Agena MassARRAY system, we genotyped four selected CYP24A1 polymorphisms. Logistic regression revealed a significant association of rs2762934 and rs1570669 with elevated bladder cancer risk, while rs6068816 exhibited a protective effect. Bioinformatics analysis of CYP24A1 expression in normal and cancerous bladder tissues indicated higher expression in normal tissue.
In conclusion, our findings highlight the potential role of CYP24A1 variants in bladder cancer susceptibility.
VitaminDWiki – Cancers might alter CYP24A1 gene
| Proper activation | makes sure that Vitamin D does not accumulate in the body |
| Too much activation | Less vitamin D actually gets to cells |
| Too little activation | Vitamin D accumulates to toxic levels ( <1 in 10,000 people) |
Blood test does not show when a poor CYP24A1 gene stops Vitamin D from getting to cells
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Several Cancers and health problems appear to protect themselves by changing CYP24A1 activation
A poor CYP24A1 reduces the Vitamin D getting to cells
without reducing measured Vitamin D level in blood